中山大学药学院导师介绍：王雪丁

5. 海洋来源的抗肿瘤候选药物SZ-685C的研究。 十一五重大专项，（分题负责）（2009.1-2015.12）

6. 个体化用药相关重要生物标志物及其新型检测试剂盒研发关键技术。十二五重大专项，（课题骨干）（2012.1-2015.12）

◆近5年发表论文

1. Chen ZJ, Wang XD, (co-first author)Wang HS, Chen SD, Zhou LM, Li JL, Shu WY, Zhou JQ, Fang ZY, Zhang Y, Huang M. Simultaneous determination of valproic acid and 2-propyl-4-pentenoic acid for the prediction of clinical adverse effects in Chinese patients with epilepsy. Seizure. 2011 Nov 3.

2. Shu WY, Wang XD, (co-first author),Yang XY, Liang L, Li JL, Chen ZJ, Chen X, Jin J, Li R, Zhao L, Huang M. Simultaneous determination of cyclophosphamide and 4-hydroxycyclophosphamide in human plasma by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry - application to Chinese systemic lupus erythematosus patients. Clin Chem Lab Med. 2011 Sep 9.

3. Chen JY, Wang XD, (co-first author), Zhong GP, Qin XL, Li JL, Huang ZY, Zhu X, Li MF, Huang M. Development and validation of a highly rapid and sensitive LC-MS/MS method for determination of SZ-685C, an investigational marine anticancer agent, in rat plasma--application to a pharmacokinetic study in rats. J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Jul 15;879(22):2127-34. Epub 2011 Jun 12.

4. Lai Y, Zhang J, Wang YX, Wang XD, Li JL, Wang YH, Zeng YJ, Huang M. CYP3A5*3 and MDR-1 C3435T single nucleotide polymorphisms in six Chinese ethnic groups. Pharmazie. 2011 Feb;66(2):136-40.

5. Ding L, Zhang FB, Liu H, Gao X, Bi HC, Wang XD, Chen BL, Zhang Y, Zhao LZ, Zhong GP, Hu PJ, Chen MH, Huang M. Hypoxanthine guanine phosphoribosyltransferase activity is related to 6-thioguanine nucleotide concentrations and thiopurine-induced leukopenia in the treatment of inflammatory bowel disease. Inflamm Bowel Dis. 2011 Mar 4.

6. Li JL, Wang XD(co-first author), Chen SY, Liu LS, Fu Q, Chen X, Teng LC, Wang CX, Huang M. Effects of diltiazem on pharmacokinetics of tacrolimus in relation to CYP3A5 genotype status in renal recipients: from retrospective to prospective. Pharmacogenomics J. 2011 Aug;11(4):300-6.

7.Yuan F, Chen J, Wu WJ, Chen SZ, Wang XD, Su Z, Huang M. Effects of Matrine and Oxymatrine on Catalytic Activity of Cytochrome P450s in Rats. Basic Clin Pharmacol Toxicol. 2010 Aug 19.

8. Qin XL, Bi HC, Wang XD, Li JL, Wang Y, Xue XP, Chen X, Wang CX, Xu le J, Wang YT, Huang M. Mechanistic understanding of the different effects of Wuzhi Tablet (Schisandra sphenanthera extract) on the absorption and first-pass intestinal and hepatic metabolism of Tacrolimus (FK506). Int J Pharm. 2010 Apr 15;389(1-2):114-21.

9. Qin XL, Bi HC, Wang CX, Li JL, Wang XD, Liu LS, Chen X, Huang M. Study of the effect of Wuzhi tablet (Schisandra sphenanthera extract) on tacrolimus tissue distribution in rat by liquid chromatography tandem mass spectrometry method. Biomed Chromatogr. 2010 Apr;24(4):399-405.

10. Wang XD, Li JL, Su QB, Guan S, Chen J, Du J, He YW, Zeng J, Zhang JX, Chen X, Huang M, Zhou SF. Impact of the haplotypes of the human pregnane X receptor gene on the basal and St John's wort-induced activity of cytochrome P450 3A4 enzyme. Br J Clin Pharmacol. 2009 Feb;67(2):255-61.

11. Wang YX, Wang CX, Li JL, Wang XD, Zhu G, Chen X, Bi H, Huang M. Effect of genetic polymorphisms of CYP3A5 and MDR1 on cyclosporine concentration during the early stage after renal transplantation in Chinese patients co-treated with diltiazem. Eur J Clin Pharmacol. 2009 Mar;65(3):239-47.

12. Li JL, Wang XD, Wang CX, Fu Q, Liu LS, Huang M, Zhou SF. Rapid and simultaneous determination of tacrolimus (FK506) and diltiazem in human whole blood by liquid chromatography-tandem mass spectrometry: application to a clinical drug-drug interaction study. J Chromatogr B Analyt Technol Biomed Life Sci. 2008 May 1;867(1):111-8 .

13. Wang XD, Deng XY, Chen J, Li JL, Chen X, Zhao LZ, Lu Y, Chowbay B, Su QB, Huang M, Zhou SF. Single nucleotide polymorphisms of the pregnane x receptor gene in Han Chinese and a comparison with other ethnic populations. Pharmacology. 2008;81(4):350-4. Epub 2008 Apr 3.

14. Wang XD, Li JL, Su QB, Deng XY, Lu Y, Chen J, Zhang JX, Zhao LZ, Zuo Z, Chan E, Chen X, Chowbay B, Xue CC, Huang M, Zhou SF. A pharmacogenetic study of pregnane X receptor (NR1I2) in Han Chinese. Curr Drug Metab. 2007 Dec;8(8):778-86.

15. Deng Y, Bi HC, Zhao LZ, Wang XD, Chen J, Ou ZM, Ding L, Xu LJ, Guan S, Chen X, Zhou SF, Huang M. Induction of cytochrome P450 3A by the Ginkgo biloba extract and bilobalides in human and rat primary hepatocytes. Drug Metab Lett. 2008 Jan;2(1):60-6.

16. Su QB, He F, Wang XD, Guan S, Xie ZY, Wang LY, Lu YJ, Gu LQ, Huang ZS, Chen X, Huang M, Zhou SF. Biotransformation and pharmacokinetics of the novel anticancer drug, SYUIQ-5, in the rat. Invest New Drugs. 2008 Apr;26(2):119-37.

17. Wang XD, Li JL, Lu Y, Chen X, Huang M, Chowbay B, Zhou SF. Rapid and simultaneous determination of nifedipine and dehydronifedipine in human plasma by liquid chromatography-tandem mass spectrometry: Application to a clinical herb-drug interaction study. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Jun 1;852(1-2):534-44. Epub 2007 Feb 21.

18. Wang XD, Chan E, Chen X, Liao XX, Tang C, Zhou ZW, Huang M, Zhou SF. Simultaneous and rapid quantitation of benazepril and benazeprilat in human plasma by high performance liquid chromatography with ultraviolet detection. J Pharm Biomed Anal. 2007 May 9;44(1):224-30

■联系方式

地址：广州市中山二路74号中山大学北校区中山大学临床药理研究所；
邮编：510080；
Email：wangxd@mail.sysu.edu.cn