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中山大学药学院导师介绍:欧田苗



Yan, J.W., et al., Design, synthesis and evaluation of isaindigotone derivatives as dual inhibitors for acetylcholinesterase and amyloid beta aggregation. Bioorg Med Chem, 2012. 20(8): p. 2527-34.
Li, Z., et al., 2-(2-indolyl-)-4(3H)-quinazolines derivates as new inhibitors of AChE: design, synthesis, biological evaluation and molecular modelling. J Enzyme Inhib Med Chem, 2012.
Xiao, N., et al., Interaction of Berberine derivative with protein POT1 affect telomere function in cancer cells. Biochem Biophys Res Commun, 2012. 419(3): p. 567-72.
Li, Z., et al., Disubstituted quinazoline derivatives as a new type of highly selective ligands for telomeric G-quadruplex DNA. Eur J Med Chem, 2012. 47(1): p. 299-311.
Chen, S.Y., et al., Design, synthesis, and biological evaluation of curcumin analogues as multifunctional agents for the treatment of Alzheimer's disease. Bioorg Med Chem, 2011. 19(18): p. 5596-604.
Hou, J.Q., et al., Impact of planarity of unfused aromatic molecules on G-quadruplex binding: learning from isaindigotone derivatives. Org Biomol Chem, 2011. 9(18): p. 6422-36.
Wu, W.B., et al., Synthesis and evaluation of mansonone F derivatives as topoisomerase inhibitors. Eur J Med Chem, 2011. 46(8): p. 3339-47.
Ma, Y., et al., Quinolino-benzo-[5, 6]-dihydroisoquindolium compounds derived from berberine: a new class of highly selective ligands for G-quadruplex DNA in c-myc oncogene. Eur J Med Chem, 2011. 46(5): p. 1906-13.
Wu, W.B., et al., Disubstituted 2-phenyl-benzopyranopyrimidine derivatives as a new type of highly selective ligands for telomeric G-quadruplex DNA. Org Biomol Chem, 2011. 9(8): p. 2975-86.
Li, Y.P., et al., Syntheses and characterization of novel oxoisoaporphine derivatives as dual inhibitors for cholinesterases and amyloid beta aggregation. Eur J Med Chem, 2011. 46(5): p. 1572-81.
Li, Y., et al., Syntheses and characterization of nimesulide derivatives for dual enzyme inhibitors of both cyclooxygenase-1/2 and 5-lipoxygenase. Bioorg Med Chem, 2011. 19(6): p. 2074-83.
Luo, W., et al., Design, synthesis and evaluation of novel tacrine-multialkoxybenzene hybrids as dual inhibitors for cholinesterases and amyloid beta aggregation. Bioorg Med Chem, 2011. 19(2): p. 763-70.
Chen, S.B., et al., Pharmacophore-based discovery of triaryl-substituted imidazole as new telomeric G-quadruplex ligand. Bioorg Med Chem Lett, 2011. 21(3): p. 1004-9.
Hou, J.Q., et al., New insights into the structures of ligand-quadruplex complexes from molecular dynamics simulations. J Phys Chem B, 2010. 114(46): p. 15301-10.
Peng, D., et al., Bisaryldiketene derivatives: A new class of selective ligands for c-myc G-quadruplex DNA. Bioorg Med Chem, 2010. 18(23): p. 8235-42.
Yan, Y.Y., et al., Selective recognition of oncogene promoter G-quadruplexes by Mg2+. Biochem Biophys Res Commun, 2010. 402(4): p. 614-8.
Wang, B., et al., Investigation on fragmentation pathways of rutaecarpine and its two derivatives using electrospray ionization ion-trap time-of-flight tandem mass spectrometry. Rapid Commun Mass Spectrom, 2010. 24(18): p. 2781-6.
An, Z.Y., et al., Synthesis and evaluation of graveoline and graveolinine derivatives with potent anti-angiogenesis activities. Eur J Med Chem, 2010. 45(9): p. 3895-903.
Wang, B., et al., Synthesis and evaluation of novel rutaecarpine derivatives and related alkaloids derivatives as selective acetylcholinesterase inhibitors. Eur J Med Chem, 2010. 45(4): p. 1415-23.
Liu, D.F., et al., Synthesis and antimultidrug resistance evaluation of icariin and its derivatives. Bioorg Med Chem Lett, 2009. 19(15): p. 4237-40.
Ma, Y., et al., Synthesis and evaluation of 9-O-substituted berberine derivatives containing aza-aromatic terminal group as highly selective telomeric G-quadruplex stabilizing ligands. Bioorg Med Chem Lett, 2009. 19(13): p. 3414-7.
Ma, Y., et al., 9-N-Substituted berberine derivatives: stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc. Bioorg Med Chem, 2008. 16(16): p. 7582-91.
Zhang, W.J., et al., 9-Substituted berberine derivatives as G-quadruplex stabilizing ligands in telomeric DNA. Bioorg Med Chem, 2007. 15(16): p. 5493-501.
Tang, W.K., et al., Inhibitory effects of Gleditsia sinensis fruit extract on telomerase activity and oncogenic expression in human esophageal squamous cell carcinoma. Int J Mol Med, 2007. 19(6): p. 953-60.
Tang, W.K., et al., Oncogenic properties of a novel gene JK-1 located in chromosome 5p and its overexpression in human esophageal squamous cell carcinoma. Int J Mol Med, 2007. 19(6): p. 915-23.

 

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