中山大学药学院导师介绍：毕惠嫦

Xue Xin-ping, Huang Min, Xiao Huan-yu, Qin Xiao-ling, Zhong Guo-ping, Bi Hui-chang*（通讯作者）. Rapid and simultaneous measurement of in vivo P-glycoprotein and Cytochrome P450 3A activity by liquid chromatography/tandem mass spectrometry based on simultaneous assay of midazolam, 1’-hydroxymidazolam and digoxin. Journal of Pharmaceutical and Biomedical Analysis. 2011; 55: 187-193.
Huang Ling, Bi Huichang, Liu Yahe, Wang Yitao, Xue Xinping, Huang Min. CAR-mediated up-regulation of CYP3A4 expression in LS174T cells by herbal compounds. Drug Metabolism and Pharmacokinetics. 2011, 26(4): 331-340.
Xiong Hui-yu, Bi Hui-chang, Wen Yu-guang, Hu Jin-qing, Zhong Guo-ping, Ou Tian-miao, Huang Zhi-shu, Huang Min. Determination of SYUIQ-F05, a novel antitumor drug, in tissues and plasma samples by liquid chromatography-tandem mass spectrometry: application to a tissue distribution study in rat. Chromatographia. 2011, 73(11-12): 1073-1080.
Liu Ya-he, Mo Sui-lin, Bi Huichang[共同第一作者], Hu Bin-fang, Li Chun-guang, Wang Yi-tao, Huang Ling, Huang Min, Zhou Shu-feng. Regulation of human pregnane X receptor and its target gene cytochrome P450 3A4 by Chinese herbal compounds and a molecular docking study. Xenobiotics, 2011, 41(4):259-280.
Lan Tian, Bi Huichang[共同第一作者], Liu Weihua, Xie Xi, Xu Suowen, Huang Heqing. Simultaneous determination of sphingosine and sphingosine 1-phosphate in biological samples by liquid chromatography–tandem mass spectrometry. Journal of Chromatography B. 879 (2011) 520–526.
Jin Jing, Bi Hui-chang, Hu Jin-qing, Zeng Hang, Zhong Guo-ping, Zhao Li-zi, Huang Zhi-ying, Huang Min. Effect of Wuzhi Tablet (Schisandra sphenanthera extract) on the Pharmacokinetics of Paclitaxel in rats. Phytotherapy Research. Jan 25, 2011. [Epub ahead of print]
Jing Wanghui, Song Yelin, Yan Ru, Bi Huichang, Li Pengtao, Wang Yitao. Transport and metabolism of (±)-praeruptorin A in Caco-2 cell monolayers. Xenobiotica. 2011, 41(1): 71-81.
Ding Liang, Zhang Fang-bin, Liu Hui, Gao Xiang, Bi Hui-chang, Wang Xue-ding, Chen Bai-li, Zhang Yu, Zhao Li-zi, Zhong Guo-ping, Hu Ping-jin, Huang Min. Hypoxanthine guanine phosphoribosyltransferase activity is related with 6-thioguanine nucleotides concentrations and thiopurine-induced myelosuppression in the treatment of inflammatory bowel disease. Inflammatory Bowel Diseases. Jan 18, 2011. Accepted.
Qin Xiao-ling, Bi Hui-chang[共同第一作者], Wang Xueding, Li Jiali, Wang Ying, Xue Xinping, Xu Lejia, Chen Xiao, Wang Changxi, Wang Yitao, Huang Min*. Mechanistic understanding of the different effects of Wuzhi Tablet (Schisandra sphenanthera extract) on the absorption and first-pass intestinal and hepatic metabolism of Tacrolimus (FK506). Int J Pharm. 2010, 389(1-2):114-121.
Qin Xiao-ling, Bi Hui-chang[共同第一作者], Wang Changxi, Li Jiali, Wang Xueding, Liu Longshan, Chen Xiao, Huang Min*. Study of the effect of Wuzhi tablet (Schisandra sphenanthera extract) on tacrolimus tissue distribution in rat by liquid chromatography tandem mass spectrometry method. Biomed Chromatogr. 2010, 24(4):399-405.
Tang Cheng, Bi Hui-chang[共同第一作者], Zhong Guo-ping, Chen Xiao, Huang Zhi-ying, Huang Min*. Simultaneous determination of mifepristone and monodemethyl-mifepristone in human plasma by liquid chromatography-tandem mass spectrometry method using levonorgestrel as an internal standard: application to a pharmacokinetic study. Biomed Chromatogr. 2009; 23(1):71-80.
He Lin, He Fan, Bi Huichang, Li Jiankang, Zeng Su, Luo Hai-Bin, Huang Min. Isoform-selective inhibition of chrysin towards human cytochrome P450. Kinetics analysis, molecular docking, and molecular dynamics simulations. Bioorg. Med. Chem. Lett. 2010, 20(20): 6008-6012.
Lan Tian, Bi Huichang, Xu Suowen, Le Kang, Xie Zhiyong, Liu Yiwei, Huang Heqing. Determination of sphingosine kinase activity in biological samples by liquid chromatography-tandem mass spectrometry. Biomed Chromatogr. 2010, 24(10):1075-1083.
Jin Jing, Bi Huichang, Hu Jinqing, Zhong Guoping, Zhao Lizi, Huang Zhiying, Huang Min*. Altered Pharmacokinetics and Bioavailability of Paclitaxel after Oral Administration of Schisandrol B in Rats. Biopharm Drug Dispos. 2010, 31(4):264-268.
Cen HJ, Zeng WT, Leng XY, Huang M, Chen X, Li JL, Huang ZY, Bi Hui-chang, Wang XD, He YL, He F, Zhou RN, Zheng QS, Zhao LZ. CYP4F2 rs2108622: a minor significant genetic factor of warfarin dose in Han Chinese patients with mechanical heart valve replacement. Br J Clin Pharmacol. 2010 Aug;70(2):234-240.
Wang Yixi, Wang Changxi, Li Jiali, Wang Xueding, Zhu Genglong, Chen Xiao, Bi Huichang, Huang Min*. Effect of genetic polymorphisms of CYP3A5 and MDR1 on Cyclosporine concentration during the early stage after renal transplantation in Chinese Patients co-treated with diltiazem. Euro J Clin Pharmaco, 2009, 65(3):239-247.
Bi Hui-chang, Zuo Zhong, Chen Xiao, Xu Chen-shu, Wen Ying-ying, Huang Min*. Preclinical factors affecting the pharmacokinetic behaviour of tanshinone IIA, an investigational new drug isolated from Salvia miltiorrhiza for the treatment of ischaemic heart diseases. Xenobiotica. 2008; 38(2): 185-222.
Pan Ying, Bi Hui-chang, Zhong Guo-ping, Chen Xiao, Zuo Zhong, Zhao Li-zi, Gu Lian-quan, Liu Pei-qing, Huang Zhi-ying, Zhou Shu-feng, Huang Min*. Pharmacokinetic characterization of hydroxylpropyl-beta-cyclodextrin-included complex of cryptotanshinone, an investigational cardiovascular drug purified from Danshen (Salvia miltiorrhiza). Xenobiotica. 2008; 38(4):382-98.
Deng Ying, Bi Hui-chang, Zhao Li-zi, Wang Xue-ding, Chen Jie, Ou Zhi-min, Ding Liang, Xu Le-jia, Guan Su, Chen Xiao, Zhou Shu-feng, Huang Min*. Induction of Cytochrome P450 3A by the Ginkgo biloba Extract and Bilobalides in Human and Rat Primary Hepatocytes. Drug Metab Letters. 2008; 2(1): 60-66.
Deng Ying, Bi Hui-chang, Zhao Li-zi, He Fan, Liu Yan-qing, Yu Jia-jun, Ou Zhi-min, Ding Liang, Chen Xiao, Huang Zhi-ying, Zhou Shu-feng, Huang Min*. Induction of cytochrome P450s by terpene trilactones and flavonoids of the Ginkgo biloba extract EGb 761 in rats. Xenobiotica. 2008; 38(5):382-398.
Zhao Li-Zi, Zhong Guo-Ping, Bi Hui-Chang, Ding Liang, Deng Ying, Guan Su, Chen Xiao, Huang Zhi-ying, Huang Min*. Determination of levonorgestrel in human plasma by liquid chromatography-tandem mass spectrometry method: application to a bioequivalence study of two formulations in healthy volunteers. Biomed Chromatogr. 2008; 22(5):519-26.
Bi Hui-chang, Law Francis C.P., Zhong Guo-ping, Xu Chen-shu, Pan Ying, Ding Liang, Chen Xiao, Zhao Li-zi, Xu Qiong, Huang Min*. Study of tanshinone IIA tissue distribution in rat by liquid chromatography-tandem mass spectrometry method. Biomed Chromatogr. 2007; 21(5):473-479.
He Fan, Bi Hui-chang, Xie Zhiyong, Zuo Zhong, Li Jiankang, Li Xin, Zhao Li-zi, Chen Xiao, Huang Min*. Rapid determination of six metabolites from multiple cytochrome P450 probe substrates in human liver microsome by liquid chromatography/mass spectrometry: application to high-throughput inhibition screening of terpenoids. Rapid Commun Mass Spectrom. 2007; 21(5): 635-643.
Guan Su, Bi Hui-Chang, Pan Ying, Chen Xiao, Zhou Zhi-wei, Xue Charlie Changli, Li Chunguang, Huang Min, Zhou Shufeng. Determination of cryptotans hi none, a major active component in Salvia miltiorrhiza, in caco-2 monolayers by HPLC with UV detection. Chromatographia. 2007; 66(7-8): 577-582.
Sun Hai-Yan, Guan Su, Bi Hui-Chang, Su Qi-Biao, Huang Wei-Lin, Chowbay B, Huang Min*, Chen Xiao, Li CG, Zhou Shu-Feng. Determination of CH330331, a novel 4-anilinoquinazoline inhibitor of epidermal growth factor receptor tyrosine kinase, in human Caco-2 monolayers by high performance liquid chromatography with ultraviolet detection: Application to a trans-epithelial transport study. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 ; 854(1-2):320-327.
Bi Hui-chang, Zhao Li-zi, Zhong Guo-ping, Zhou Shufeng, Li Bo, Deng Ying, Chen Xiao, Huang Min*. High-throughput determination of carbocysteine in human plasma by liquid chromatography-tandem mass spectrometry method: application to a bioequivalence study of two formulations in healthy volunteers. Rapid Commun Mass Spectrom. 2006; 20(7):1153-1160.
Zhang Jing, Huang Min*, Guan Su, Bi Hui-Chang, Pan Ying, Duan Wei, Chan Sui-Yung, Chen Xiao, Hong Yun-Han, Bian Jin-Song, Yang Hong-Yuan, and Zhou Shufeng. A Mechanistic Study of the Intestinal Absorption of Cryptotanshinone, the Major Active Constituent of Salvia miltiorrhiza. J Pharmacol Exp Ther. 2006; 317(3): 1285-1294.

■ 联系方式

地址：广州市大学城外环东路132号 中山大学药学院
邮编：510006
Email：bihchang@mail.sysu.edu.cn