天津科技大学生物工程学院硕士生导师介绍：韩培培

　　个人简介

　　办公电话：************

　　电子邮件：pphan@tust.edu.cn

　　通讯地址：天津经济技术开发区第十三大街29号天津科技大学生物工程学院

　　研究方向: [1]天然食品配料的发酵生产 [2]微生物活性多糖的开发与应用[3]微藻培养与活性物质开发 [4]微

　　招生专业

　　代表性论文

　　[1]Pei-pei Han*, Shi-gang Shen, Rong-jun Guo, Dong-xue Zhao, Ya-Hui Lin, Shi-ru Jia*, Rong-rong Yan, and Yi-kai Wu. ROS Is a Factor Regulating the Increased Polysaccharide Production by Light Quality in the Edible Cyanobacterium Nostoc flagelliforme. J. Agric. Food Chem., 2019, 67 (8): 2235–2244.

　　[2]Shi-Gang Shen, Ya-Hui Lin, Dong-Xue Zhao, Yi-Kai Wu, Rong-Rong Yan, Hua-Bing Zhao, Zhi-Lei Tan*, Shi-Ru Jia* and Pei-Pei Han *. Comparisons of Functional Properties of Polysaccharides from Nostoc flagelliforme under Three Culture Conditions. Polymers 2019, 11(2), 263

　　[3]Shi-gang Shen, Shi-ru Jia, Yi-kai Wu, Rong-rong Yan, Ya-Hui Lin, Dong-xue Zhao, Pei-pei Han*. Effect of culture conditions on the physicochemical properties and antioxidant activities of polysaccharides from Nostoc flagelliforme. Carbohydrate Polymers, 2018, 198: 426-433

　　[4]Shi-gang Shen, Rong-jun Guo, Rong-rong Yan, Yi-kai Wu, Dong-xue Zhao, Ya-hui Lin, He-xin Lv, Shi-ru Jia*, Pei-pei Han*. Comparative proteomic analysis of Nostoc flagelliforme reveals the difference in adaptive mechanism in response to different ultraviolet-B radiation treatments. Molecular Biology Reports, 2018, 45(6): 1995–2006

　　[5]Shi-gang Shen, Shi-ru Jia, Rong-rong Yan, Yi-kai Wu, Hui-yan Wang, Ya-hui Lin, Dong-xue Zhao, Zhi-lei Tan, He-xin Lv and Pei-pei Han*. The physiological responses of terrestrial cyanobacterium Nostoc flagelliforme to different intensities of ultraviolet-B radiation. RSC Advances, 2018, 8, 21065-21074

　　[6]Pei-pei Han*, Rong-jun Guo, Shi-gang Shen, Rong-rong Yan, Yi-kai Wu, Shun-yu Yao, Hui-yan Wang, Shi-ru Jia*. Proteomic profiling of Nostoc flagelliforme reveals the common mechanism in promoting polysaccharide production by different light qualities. Biochemical Engineering Journal 132 (2018) 68–78.

　　[7]Pei-pei Han, Shi-gang Shen, Rong-jun Guo, Shun-yu Yao, Ying Sun, Zhi-lei Tan, Shi-ru Jia*. The regulation of photosynthetic pigments in terrestrial Nostoc flagelliforme in response to different light colors. Algal Research 25 (2017) 128–135

　　[8]Pei-pei Han* Shun-yu Yao, Rong-jun Guo, Rong-rong Yan, Yi-kai Wu, Shi-gang Shen, Shi-ru Jia*. Influence of culture conditions on extracellular polysaccharide production and the activities of enzymes involved in the polysaccharide synthesis of Nostoc flagelliforme. RSC Advances, 2017, 7, 45075-45084

　　[9]Pei-pei Han*, Shun-yu Yao, Rong-jun Guo, Shi-gang Shen, Rong-rong Yan, Zhi-lei Tan, Shi-ru Jia*. The relationship between monosaccharide composition of extracellular polysaccharide and activities of related enzymes in Nostoc flagelliforme under different culture conditions. Carbohydrate Polymers 174 (2017) 111–119

　　[10]Pei-pei Han, Shi-gang Shen, Hui-Yan Wang, Shun-yu Yao, Zhi-lei Tan,  Cheng Zhong, Shi-ru Jia*. Applying the strategy of light environment control to improve the biomass and polysaccharide production of Nostoc flagelliforme. Journal of Applied Phycology,2017, 29(1):55-65

　　[11]Pei-pei Han, Shi-gang Shen, Hui-Yan Wang, Ying Sun, Yu-jie Dai, Shi-ru Jia*. Comparative metabolomic analysis of the effects of light quality on polysaccharide production of cyanobacterium Nostoc flagelliforme. Algal Research-Biomass Biofuels and Bioproducts, 2015, 9: 143-150.

　　[12]Pei-pei Han, Shi-gang Shen, Shi-ru Jia, Hui-yan Wang, Cheng Zhong, Zhi-lei Tan, He-xin Lv. Comparison of bacterial community structures of terrestrial cyanobacterium Nostoc flagelliforme in three different regions of China using PCR-DGGE analysis. World Journal of Microbiology and Biotechnology, 2015, 31(7):1061-1069.

　　[13]Pei-pei Han, Ying Sun, Shi-ru Jia*, Cheng Zhong, Zhi-lei Tan. Effects of light wavelengths on extracellular and capsular polysaccharide production by Nostoc flagelliforme. Carbohydrate Polymers, 2014, 105: 145–151.

　　[14]Pei-pei Han, Ying Sun, Xiao-ying Wu, Ying-jin Yuan, Yu-jie Dai, Shi-ru Jia*. Emulsifying, Flocculating, and Physicochemical Properties of Exopolysaccharide Produced by Cyanobacterium Nostoc flagelliforme. Applied Biochemistry and Biotechnology, 2014,  172(1): 36-49.

　　[15]Pei-pei Han, Shi-ru Jia*, Ying Sun, Zhi-lei Tan, Cheng Zhong, Yu-jie Dai, Ning Tan, Shi-gang Shen. Metabolomic approach to optimizing and evaluating antibiotic treatment in the axenic culture of cyanobacterium Nostoc flagelliforme. World Journal of Microbiology & Biotechnology 2014, 30 (9): 2407-2418.

　　[16]Pei-pei Han, Ting-xiang Ye, Bin Qiao, Ying-jin Yuan*. Taxoids profiling of suspension Taxus chinensis var. mairei cells in response to shear stress. Biochemical Engineering Journal. 2013, 77: 66-73.

　　[17]Pei-Pei Han and Ying-Jin Yuan*. Lipidomic analysis reveals activation of phospholipid signaling in mechanotransduction of Taxus cuspidata cells in response to shear stress. FASEB Journal. 2009, 23: 623-630.

　　[18]Pei-Pei Han and Ying-Jin Yuan*. Metabolic profiling as a tool for understanding defense response of Taxus cuspidata cells to shear stress. Biotechnology Progress. 2009, 25: 1244-1253.

　　[19]Pei-pei Han, Jian Zhou and Ying-jin Yuan*. Analysis of phospholipids, sterols, and fatty acids in Taxus chinensis var. mairei cells in response to shear stress. Biotechnology and Applied Biochemistry.2009, 54: 105–112.

　　[20]Tao Bo, Pei-Pei Han, Qin-Zhi Su, Ping Fu, Feng-Zhu Guo, Zuo-Xing Zheng, Zhi-Lei Tan, Cheng Zhong, Shi-Ru Jia*, Antimicrobial epsilon-poly-L-lysine induced changes in cell membrane compositions and properties of Saccharomyces cerevisiae, Food Control, 2016, 61:123-134.

　　[21]Tao Bo, Miao Liu, Cheng Zhong, Qian Zhang, Qin-zhi Su, Zhi-lei Tan, Pei-pei Han, Shiru Jia. Metabolomic Analysis of Antimicrobial Mechanisms of epsilon-Poly-L-lysine on Saccharomyces cerevisiae. Journal of Agricultural and Food Chemistry, 2014, 62(19): 4454-4465.

　　[22]Cheng Zhong, Gui-Cai Zhang, Miao Liu, Xin-Tong Zheng, Pei-Pei Han, Shi-Ru Jia*, Metabolic flux analysis of Gluconacetobacter xylinus for bacterial cellulose production, Applied Microbiology and Biotechnology, 2013, 97:6189-6199

　　[23]Zhen Ding, Shiru Jia, Pei-pei Han, Nannan Yuan, Ning Tan. Effects of carbon sources on growth and extracellular polysaccharide production of Nostoc flagelliforme under heterotrophic high-cell-density fed-batch cultures. Journal of Applied Phycology, 2013, 25(4): 1017-1021

　　[24]Cheng Zhong, Rui Wang, Zhao Zhou, Shi-Ru Jia*, Zhi-Lei Tan, Pei-Pei Han, Functional properties of protein isolates from Caragana Korshinskii Kom. extracted by three different methods, Journal of Agricultural and Food Chemistry, 2012, 60: 10337-10342

　　[25]韩培培，贾士儒。发菜细胞培养的研究进展。天津科技大学学报，2016,31（2）：1-5.

　　主要著作

　　[1]贾士儒，韩培培，戴玉杰，吕和鑫等著。发菜细胞培养，科学出版社，2014 （获天津市科协自然科学学术专著基金出版资助）

　　[2]贾士儒主编。生物反应工程原理（第四版），科学出版社，2015

　　[3]贾士儒，宋存江主编。发酵工程实验教程，高等教育出版社，2016。（参编）

　　科研项目

　　[1]国家自然科学基金面上项目：液体发酵过程发菜多糖生物合成的调控机制研究，项目负责人

　　[2]国家自然科学基金青年项目：发状念珠蓝细菌多糖合成代谢的光调控机制研究，项目负责人

　　[3]工业发酵微生物教育部重点实验室“生工英才培育计划”，项目负责人

　　[4]国家863计划课题：能源和医药产品模块化设计合成，子课题负责人

　　[5]企业委托课题：液体发酵灵芝多糖和灰树花多糖产量提高及其抗氧化、抗辐射活性研究，项目负责人

　　[6]企业委托课题：海洋环境下混凝土结构生物膜组成研究，项目负责人

　　[7]企业委托课题：淤泥中活性微生物的鉴定分析，项目负责人

　　[8]企业委托课题：海洋环境下混凝土结构生物膜组成研究，项目负责人

　　[9]企业委托课题：微生物对淤泥质港口减淤作用实验，项目负责人

　　[10]行业重点实验室开放课题：延缓浮泥沉降的化能自养微生物筛选研究，项目负责人

　　其他（获奖成果、专利）等

　　近期申请专利

　　[1]韩培培 张晓琪 贾士儒 李梦楠  谭之磊 钟成，一株嗜甲基营养菌菌株及其应用，201811053889.4，2018.9.11

　　[2]韩培培 张晓琪 庞启秀 贾士儒 钟成 谭之磊，用于淤泥质港口减淤的微生物菌剂的制备方法，201811053725.1, 2018.9.11

　　[3]韩培培 李梦楠 张晓琪 贾士儒 钟成 谭之磊，利用微生物矿化制备不同晶型碳酸钙的方法，201811072160.1，2018.9.14

　　[4]韩培培、闫荣荣、贾士儒、娄倩倩、赵冬雪、钟成，一种同时提高发菜细胞密度和多糖产量的方法，201810225802.0，2018.03.19

　　[5]韩培培、闫荣荣、贾士儒、申世刚、武毅凯、林亚慧、谭之磊，一种高效生产发菜胞外多糖的方法，201810225270.0，2018.03.19

　　[6]韩培培 李梦楠 张晓琪 贾士儒 谭之磊 钟成， 利用两种微生物共同矿化制备碳酸钙的方法，201810151338.5，2018.02.08

　　[7]韩培培 陈晓华 李梦楠 贾士儒 庞启秀 谭之磊 钟成，一种延缓淤泥质港口浮泥密实的简易方法，201710014600.7

　　[8]韩培培，贾士儒，戴玉杰，乔长晟，谭之磊，钟成，一种藻类生物絮凝剂及其制备方法，201310226458.4，2017.1.10

　　[9]贾士儒，王甜，谭之磊，韩培培，戴玉杰，钟成，宋帅，张雪。一种ε-聚-L-赖氨酸的生产方法，中国，ZL201110333684.3 （已授权）

　　[10]贾士儒，钟成，王蕊，周昭，谭之磊，韩培培，史晓伟。一种提高锦鸡儿属饲料适口性的方法，中国，ZL201210465173.1 （已授权）

　　[11]贾士儒，郭爱楠，戴玉杰，谭之磊，郑欣桐，韩培培，任忠，刘学斌。一种CO2气体中和壳聚糖制备过程中碱性物质的方法，中国，ZL201210161041.X （已授权）

　　获奖情况

　　[1]指导2011级、2013级研究生获得国家奖学金

　　[2]指导多位大四本科毕业生获得院级优秀毕业论文

　　[3]2014年度天津科技大学“五比双创”教工先锋岗荣誉称号

　　[4]2016年度“创青春”天津科技大学创业大赛优秀指导教师

　　[5]2015-2016学年度师生一帮一助学活动先进个人