天津科技大学生物工程学院硕士生导师介绍：满淑丽

　　个人简介

　　办公电话：************

　　电子邮件：msl@tust.edu.cn

　　通讯地址：天津经济技术开发区第十三大街29号天津科技大学生物工程学院

　　研究方向: [1]天然产品的提取分离与活性研究； [2]中药成分鉴定及体内代谢研究； [3]中药组方配伍机制研究

　　招生专业

　　代表性论文

　　长期从事天然产物成分分离、鉴定及活性开发等研究，参与课题多项，其中主持国家及省部级项目3项。尤其是对甾体皂苷类成分的鉴定、抗肿瘤成药性、作用机制的阐述、安全性等方面开展了一系列研究。相关成果包括作为第一作者或通讯作者发表SCI论文40余篇；其中一、二区论文20篇，累积影响因子120；目前论文累积引用八百余次，单篇最高引用280次。近五年发表的主要学术论文有：

　　[1] Man SL*, Zhang LL, Cui JX, Yang L, Ma L, Gao WY*. Curcumin enhances the anti-cancer effects of Paris Saponin II in lung cancer cells. Cell Proliferation. 2018: e12458.

　　[2] Man SL*, Chai HY, Cui JX, Yao JW, Ma L, Gao WY*. Antitumor and anti-metastatic mechanisms of Rhizoma paridis saponins in Lewis mice. Environmental Toxicology. 2018; 33(2): 149-155.

　　[3] Man SL, Ma J, Yao JW, Cui JX, Wang CX, Li Y, Ma L*, Lu FP*. Systemic perturbations of key metabolites in Type 2 diabetic rats treated by polyphenols extracts from Litchi chinensis seeds. J Agric Food Chem. 2017; 65(35):7698-704

　　[4] Man SL*, Li J, Qiu PY, Liu J, Liu Z, Ma L, Gao WY*. Inhibition of lung cancer in diethylnitrosamine-induced mice by Rhizoma paridis saponins. Molecular Carcinogenesis. 2017; 56:1405-13.

　　[5] Man SL, Qiu PY, Li J, Zhang LM, Gao WY*. Global metabolic profiling for the study of Rhizoma Paridis Saponins induced hepatotoxicity in rats. Environmental Toxicology. 2017; 32:99-108.

　　[6] Qiu PY, Sun JC, Man SL*, Yang H, Ma L, Yu P, Gao WY*. Curcumin attenuates N- nitrosodiethylamine induced liver injury in mice by utilizing the method of metabonomics. J Agric Food Chem. 2017; 65 (9), 2000-7.

　　[7] Man SL, Li J, Liu J, Fan W, Liu Z, Wang JM, Gao WY*. Curcumin alleviated the toxic reaction of Rhizoma paridis saponins in a 45-day subchronic toxicological assessment of rats. Environmental Toxicology. 2016; 31: 1935-43.

　　[8] Qiu PY, Man SL*, Yang H, Fan W, Yu P, Gao WY*. Utilization of metabonomics to identify serum biomarkers in murine H22 hepatocarcinoma and deduce antitumor mechanism of Rhizoma Paridis saponins. Chemico-biological interactions. 2016; 256: 55-63.

　　[9] Qiu PY, Man SL*, Li J, Liu J, Zhang LM, Yu P, Gao WY*. Overdose Intake of Curcumin Initiates the Unbalanced State of Bodies. J Agric Food Chem. 2016; 64: 2765-71.

　　[10] Qiu PY, Man SL*, Yang H, Liu YX, Liu Z, Ma L, Yu P, Gao WY*. Metabolic regulatory network alterations reveals different therapeutic effects of cisplatin and Rhizoma paridis saponins in Lewis pulmonary adenoma mice. RSC Advances. 2016; 6: 115029 - 38.

　　[11] Liu J, Liu Z, Man SL*, Chai HY, Ma L, Gao WY*. Inhibition of urethane-induced lung carcinogenesis in mice by Rhizoma paridis saponins involved EGFR/PI3K/Akt pathway. RSC Advances. 2016; 6: 92330 - 4.

　　[12] Liu J, Man SL*, Liu Z, Ma L, Gao WY*. A synergistic antitumor effect of Polyphyllin I and Formosanin C on hepatocarcinoma cells. Bioorganic & Medicinal Chemistry Letters. 2016; 26: 4970-5.

　　[13] Liu J, Man SL*, Li J, Zhang Y, Meng X, Gao WY*. Inhibition of diethylnitrosamine-induced liver cancer in rats by Rhizoma paridis saponin. Environmental Toxicology and Pharmacology. 2016; 46: 103-9.

　　[14] Zhang LL, Man SL*, Qiu HN, Liu Z, Zhang M, Ma L, Gao WY*. Curcumin-cyclodextrin complexes enhanced the anti-cancer effects of curcumin. Environmental Toxicology and Pharmacology. 2016; 48: 31-8.

　　[15] Zhang LL, Man SL*, Wang YS, Liu J, Liu Z, Yu P, Gao WY*. Paris Saponin II induced apoptosis via activation of autophagy in human lung cancer cells. Chemico-Biological Interactions. 2016; 253: 125-133.

　　[16] Li J, Man SL*, Qiu PY, Fan W, Zhang LM, Gao WY*. Toxicological risks of Rhizoma Paridis saponins in rats involved NF-κB and Nrf2 signaling. RSC Advances. 2016; 6: 31889-31897.

　　[17] Man SL*, Ma J, Wang CX, Li Y, Gao WY, Lu FP*. Chemical composition and hypoglycaemic effect of polyphenol extracts from Litchi chinensis seeds. J Funct Foods. 2016; 22: 313-24.

　　[18] Man SL, Li J, Fan W, Chai HY, Liu Z, Gao WY*. Inhibition of pulmonary adenoma in diethylnitrosamine-induced rats by Rhizoma paridis saponins. J Steroid Biochem Mol Biol. 2015; 154: 62-67.

　　[19] Man SL, Chai HY, Qiu PY, Fan W, Liu Z, Wang JM, Gao WY*. Turmeric enhancing anti-tumor effect of Rhizoma paridis saponins by influencing their metabolic profiling in tumors of H22 hepatocarcinoma mice. Pathol Res Pract. 2015; 211: 948-54.

　　[20] Li YY, Man SL*, Li J, Chai HY, Fan W, Liu Z, Gao WY*. The antitumor effect of formosanin C on HepG2 cell as revealed by 1H-NMR based metabolic profiling. Chemico-Biological Interactions. 2014; 220C: 193-9.

　　[21] Man SL, Fan W, Liu Z, Gao WY, Li YY, Zhang LM, Liu CX. Antitumor pathway of Rhizoma Paridis Saponins based on the metabolic regulatory network alterations in H22 hepatocarcinoma mice. Steroids. 2014; 84:17-21.

　　[22] Man SL, Li YY, Fan W, Gao WY, Liu Z, Zhang Y, Liu CX. Combination therapy of cyclophosphamide and Rhizoma Paridis Saponins on anti-hepatocarcinoma mice and effects on cytochrome p450 enzyme expression. Steroids. 2014; 80:1-6.

　　[23] Man SL, Fan W, Gao WY, Li YY, Wang Y, Liu Z, Li HF. Anti-fibrosis and anti-cirrhosis effects of Rhizoma paridis saponins on diethylnitrosamine induced rats. J Ethnopharmacol. 2014; 151:407-412.

　　科研项目

　　[1] 国家自然科学基金项目：基于肿瘤微环境干预的重楼皂苷抗转移性肺癌作用机制及物质基础研究，2017-2020，项目负责人。

　　[2] 国家自然科学基金项目：基于代谢调控网络干预的重楼总皂苷组分配伍机制研究，2012-2015，项目负责人。

　　[3] 天津市自然科学基金项目：基于细胞周期阻滞的楼黄配伍作用机制研究，2012-2015，项目负责人。