天津科技大学食品工程与生物技术学院硕士生导师介绍：王帅

　　个人简介

　　办公电话：************

　　电子邮件：wangshuai@tust.edu.cn

　　通讯地址：天津经济技术开发区十三大街29号

　　研究方向: 1.风味化学  2.碳水化合物相关机理研究  3.糖化学与糖生物学

　　招生专业

　　代表性论文

　　1) Angeli A., Li M., Dupin L., Vergoten G., No?l M., Madaoui M., Wang S., Meyer A., Gehin T., Vidal S., Vasseur J-J., Chevolot Y., Morvan F. “Design and synthesis of galactosylated bifurcated ligands with nanomolar affinity for lectin LecA from Pseudomonas aeruginosa” ChemBioChem, 2017, 18, 1036-1047.

　　2) Wang S., Dupin L., No?l M., Carroux C. J., Renaud L., Meyer A., Souteyrand E., Vasseur J-J., Vergoten G., Chevolot Y., Morvan F., Vidal S. “Toward the rational design of galactosylated glycoclusters that target Pseudomonas aeruginosa Lectin A (LecA): influence of linker arms that lead to low-nanomolar multivalent ligands” Chem. Eur. J., 2016, 22, 11785-11794.

　　3) Wang S., Cuesta-Seijo J. A., Striebeck A., Lafont D., Palcic M. M., Vidal S. “Design of glycosyltransferase inhibitors: serine analogues as pyrophosphate surrogates?” ChemPlusChem, 2015, 80, 1525-1532.

　　4) Wang S., Galanos N., Rousset A., et al. “Fucosylation of triethyleneglycol-based acceptors into “clickable” α-fucosides” Carbohydr. Res., 2014, 395, 15-18.

　　5) Wang S., Shen D. L., Lafont D., Vercoutter-Edouart A-S., Mortuaire M., Shi Y., Maniti O., Girard-Egrot A., Lefebvre T., Pinto B. M., Vocadlo D., and Vidal S. “Design of glycosyltransferase inhibitors targeting human O-GlcNAc Transferase (OGT)” MedChemComm, 2014, 5, 1172-1178.

　　6) Wang S., Cuesta-Seijo J. A., Lafont D., Palcic M. M., and Vidal S. “Design of glycosyltransferase inhibitors: Pyridine as a pyrophosphate surrogate” Chem. Eur. J., 2013, 19, 15346-15357.

　　7) Wang S., Lafont D., Rahkila J., Picod B., Leino R. and Vidal S. “Glycosylation of 'basic' alcohols: methyl 6-(hydroxymethyl)picolinate as a case study” Carbohydr. Res., 2013, 372, 35-46.

　　主要著作

　　Book Chapter: Wang S., Vidal S. “Recent design of glycosyltransferase inhibitors” in “Carbohydrate Chemistry: Specialist Periodical Reports” Rauter A. P., Lindhorst T. Eds.; RSC Publishing : Cambridge, 2013, 39, 78-101.

　　科研项目

　　1. 法国高等教育与科研部国际奖学金资助项目: 中性糖基转移酶抑制剂的设计与合成

　　2. 法国国家科研署(ANR)资助项目: 具有凝集素亲和性的簇状糖缀合物的设计与合成

　　3. 法国Laboratories of excellence ARCANE(LABEX)资助项目：以蛋白酶为目标靶点的Salinosporamide类似物的设计与合成

　　4. 法国国家科研署(ANR)资助项目：应用于超高分辨显影的磷脂酰肌醇-4,5-二磷酸脂类似物的设计与合成