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中科院上海有机化学研究所导师介绍:刘文


4.Chen, Y.; Deng, W.; Wu, J.; Qian, J.; Chu, J.; Zhuang, Y.; Zhang, S.; Liu, W. Genetic modulation of the overexpression of tailoring genes eryK and eryG leading to the improvement of erythromycin A purity and production in fermentation of Saccharopolyspora erythraea. Appl. Environ. Microbiol. 2008, 74, 1820-1828.

5.Fang, J.; Zhang, Y.; Huang, L.; Jia, X.; Zhang, Q.; Zhang, X. Tang, G.; Liu, W. Cloning and characterization of the tetrocarcin A gene cluster from Micromonospora chalcea NRRL 11289 reveals a highly conserved stratety fro tetronate biosynthesis in spirotetronate antibiotics. J. Bacteriol. 2008, 190, 6014-6025.

6.Zhao, Q.; He, Q.; Ding, W.; Tang, M.; Kang, Q.; Yu, Y.; Deng, W.; Zhang, Q.; Fang, J.; Tang, G.; Liu, W. Characterization of the azinomycin B biosynthetic gene cluster revealing a different iterative type I polyketide synthase for naphthoate biosynthesis. Chem. & Biol. 2008, 15, 693-705 (Featured in: Antibiotic biosynthesis: from Genes to Enzymes. Nature China 2008, doi:10.1038/nchina.2008.196).

7.He, Q.; Jia, X.; Tang, M.; Tian, Z.; Tang, G.; Liu, W. Dissection of two transfer reactions centered on acyl-S-carrier protein intermediates for incorporating 5-chloro-6-methyl-O-methylsalicyclic acid into chlorothricin. ChemBioChem 2009, 10, 813-819.

8.Liao, R.; Duan, L.; Lei, C.; Pan, H.; Ding, Y.; Zhang, Q.; Chen, D.; Shen, B.; Yu, Y.; Liu, W. Thiopeptide biosynthesis featuring ribosomally synthesized precursor peptides and conserved posttranslational modifications. Chem. & Biol. 2009, 16, 141-14 (Featured in: Biosynthetic pathway for the production of thiopeptide antibiotics. SciBX 2(10), 2009, Doi: 10.1038/scibx.2009.423).

9. Liu, W. & Yu, Y. Combinatorial Biosynthesis of pharmaceutical natural products. Ed. By Tao, J. & Lin, G. Biocatalysis for the pharmaceutical industry-discovery, development and manufacturing. John Wiley & Sons Pte Ltd, 2009, pp229-245.

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