湖南大学生物学院导师介绍：曾嘉

　　姓名：曾嘉　　性别：男　　籍贯：湖南湘潭

　　民族：汉族　　民族：1977年6月　　学院：生物学院

　　职称：副教授　　导师类型：硕士生导师

　　1999年6月获武汉工程大学化学工艺学士学位，2002年3月获浙江大学生物化工硕士学位，2006年1月获香港城市大学生物化学博士学位。主要从事脂肪代谢疾病发病机制研究及相关药物开发。近五年来在Biochemistry，Org. Lett，FEBS Lett, BBA，Bioorg. Med. Chem. Lett.，Arch. Biochem. Biophys.等国际刊物发表SCI收录论文30余篇，其中影响因子3.0以上的12篇。指导研究生12人。

　　目前主持国家自然科学基金及教育部博士点基金各一项，湖南大学985专项资助项目及创新基金各一项，作为主要成员参与科技部973项目二项，国家自然基金创新群体基金一项，香港特别行政区研究发展局项目三项。

　　代表性论文：

　　1. Jia Zeng, Xiaojian Zhang, Yiping Wang, Chenbing Ai, Qing Liu and Guanzhou Qiu. Glu43 is an essential residue for coordinating the [Fe2S2] cluster of IscR from Acidithiobacillus ferrooxidans. FEBS Lett. 2008, 582, 3889-3892.

　　2. Jia Zeng, Ke Zhang, Jianshe Liu, Guanzhou Qiu. Expression, purification and characterization of an Iron-Sulfur cluster assembly regulator IscR from Acidithiobacillus ferrooxidans. J. Microbiol. Biotechnol. 2008, 18, 1672-1677.

　　3. Huidan Jiang, Xiaojian Zhang, Chenbin Ai, Yuandong Liu, Jianshe Liu, Guanzhou Qiu, Jia Zeng. Asp97 is a crucial residue involved in the ligation of the [Fe4S4] cluster of IscA from Acidithiobacillus ferrooxidans. J. Microbiol. Biotechnol. 2008, 18, 1070-1075.

　　4. Jia Zeng, Long Wu, Xiaojian Zhang, Yuandong Liu, Guisheng Deng, Ding Li Oct-2-en-4-ynoyl-CoA as a specific inhibitor of acyl-CoA oxidase. Org. Lett. 2008, 10, 4287-4290.

　　5. Jia Zeng, Huidan Jiang, Meimei Geng, Yiping Wang, Xiaojian Zhang, Jianshe Liu, Guanzhou Qiu. In vitro assembly of [Fe4S4] cluster in high potential iron-sulfur protein from Acidithiobacillus ferrooxidans. Current Microbiology 2008, 57, 161-166.

　　6. Jia Zeng, Huidan Jiang, Yuandong Liu, Jianshe Liu, and Guanzhou Qiu. Expression, purification and characterization of a high potential iron-sulfur protein from Acidithiobacillus ferrooxidans. Biotech. Lett. 2008, 30, 905-910. 7. Jia Zeng, Xia Huang, Yuandong Liu, Jianshe Liu, and Guanzhou Qiu. Expression, purification and characterization of a [Fe2S2] cluster containing ferredoxin from Acidithiobacillus ferrooxidans. Current Microbiology 2007, 55:518-523.

　　8. Jia Zeng, Yuandong Liu, Long Wu, Ding Li. Mutation of Tyr375 to Lys375 allows medium-chain acyl-CoA dehydrogenase to acquire acyl-CoA oxidase activity. Biochim. Biophis. Acta 2007, 1774:1628-1634.9. Long Wu, Jia Zeng, Guisheng Deng, Fei Guo, Nan Li, Xiaojun Liu, Xiusheng Chu, and Ding Li. Inactivation of thiolase by 2-alkynoyl-CoA via its intrinsic isomerase activity. Org. Lett. 2007, 9:3877-3880.

　　10. Jia Zeng, Meimei Geng, Huidan Jiang, Yuandong Liu, Jianshe Liu, and GuanzhouQiu. The Isc A from Acidithiobacillus ferrooxidans is an iron-sulfur protein which assemble the [Fe4S4] Cluster with intracellular iron and sulfur. Arch. Biochem. Biophys. 2007, 463:237-244.

　　11. Jia Zeng, Meimei Geng, Yuandong Liu, Lexian Xia, Jianshe Liu and Guanzhou Qiu. The sulfhydryl group of Cys138 of rusticyanin from Acidithiobacillus ferrooxidans is crucial for copper binding. Biochim. Biophis. Acta. 2007, 1774:519-525.

　　12. Jia Zeng, Meimei Geng, Yuandong Liu, Wenjie Zhao, Lexian Xia, Jianshe Liu, and Guanzhou Qiu. Expression, purification and molecular modeling of the Iro protein from Acidithiobacillus ferrooxidans Fe-1. Protein Expr. Purif. 2007, 52:146-152.

　　13. Jia Zeng, Guisheng Deng, Wenhua Yu, Ding Li. Inactivation of medium-chain acyl-CoA dehydrogenase by oct-4-en-2-ynoyl-CoA. Bioorganic and Medicinal Chemistry Letters. 2006, 16:1445-1448.

　　14. Jia Zeng, Guisheng Deng, Ding Li. Intrinsic enoyl-CoA isomerase activity of acyl-CoA oxidase I. Biochim. Biophis. Acta. 2006, 1760:78-85.

　　15. Jia Zeng，Ding Li. Intrinsic isomerase activity of medium-chain acyl-CoA dehydrogenase. Biochemistry 2005, 44:6715-6722.

　　联系方式：
　　E-mail: zengj@hnu.edu.cn