哈工大土木工程学院导师介绍：孙艳

　　孙艳，博士，硕士生导师。1997-2005年在中国科学院大连化学物理研究所攻读博士学位并留所工作。2005年于西班牙纳瓦拉大学药学院进行博士后研究。回国后进入哈尔滨工业大学，主持国家自然科学基金项目“具有“门禁”，孔道修饰和形貌可控的介孔氧化硅纳米颗粒应用于siRNA靶向转染与控制释放的研究（3090036）”、博士点基金（20092302120070）、城市水资源与水环境国家重点实验室开放研究基金重点项目（QAK200809），以及黑龙江省教育厅科学技术研究项目、哈尔滨市创新人才基金、黑龙江省新世纪高等教育教学改革工程项目和哈尔滨工业大学创新基金等多项科研项目，并参加国家十一五科技支撑和863等多项国家项目。并负责生物工程平台的筹备与建设工作。目前主要从事非病毒载体、基因和药物转运系统、纳米生物材料的研究，成果在Biophysical Journal 和Journal of Colloid and Interface Science等国际刊物上发表。

　　专业： 生物工程 联系电话： *************
　　电子信箱： yansun@hit.edu.cn
　　通讯地址：哈尔滨工业大学437信箱
　　邮编：150001
　　
　　简历
　　1992.9–1996.8 大连理工大学化工学院化学工程专业 获学士学位
　　1996.9–1997.7 大连理工大学信息工程学院计算机应用 获双学士学位
　　1997.8–2004.2 中科院大连化学物理研究所生物化工 获博士学位
　　2004.3–2005.5 中科院大连化学物理研究所生物技术部 助理研究员
　　2005.5–2006.6 西班牙Univeristy of Navarra大学 博士后
　　2006.7-至今 哈尔滨工业大学生命科学与技术学院 副教授
　　
　　研究方向：
　　1. 非病毒基因载体和多功能的药物基因纳米转运系统
　　2. 生物质的微生物利用
　　3. 生物纳米材料的胶体表面化学与物理化学特性
　　
　　发表科研论文
　　Invited Review
　　1．Conchita Tros de Ilarduya*, Yan Sun, Nejat Düzgüneş. Gene delivery by lipoplexes and polyplexes (review). European Journal of Pharmaceutical Sciences, 2010, 40(3): 159-170
　　2．Yan Sun. Rheological approach to targeting phenomena of lipoplexes (review). Current Drug Discovery Technologies, 2011, 8(4): 340-356
　　
　　Publications
　　1．Yan Sun, Qi Hu, Xuetuo Li. The current situation and the development prospect of the urban environmental protection techniques in our country. Journal of Dalian University of Technology (Social Sciences), 2000, 21(s1): 48-51
　　2．Yan Sun, Xuetuo Li, Sulan Yin. Effect of intestinal microecological environment on internal metabolism of traditional Chinese herbs. Zhongcaoyao (Chinese Traditional and Herbal Drugs), 2001, 32(4): 375-377
　　3．Yan Sun, Xuetuo Li, Nejat Düzgüneş, Yasuyuki Takaoka, Sho-ichi Ohi, Sadao Hirota*. The shape parameter of liposomes and DNA-lipid complexes determined by viscometry utilizing small sample volumes. Biophysical Journal 2003; 85(2): 1223-1232
　　4．Yan Sun*, Xingju Yu, Yasuyuki Takaoka, Sho-ichi Ohi, Nejat Düzgüneş, Sadao Hirota. Comparison of shape of DNA-cationic lipid complexes and model polyelectrolyte-lipid complexes. Journal of Colloid and Interface Science, 2004; 276(2): 317-322
　　5．Yan Sun, Bo Liu, JingMei Zhao, HaiYan Wang, SuLan Yin, XueTuo Li. Effect of preparation of spirulina on intestinal flora of diabetic. Journal of Shenyang Pharmaceutical University (Chinese), 2003, 20 (4): 299-301
　　6．Yan Sun, Bo Liu, Jingmei Zhao, Haiyan Wang, Heli Xu, Xuetuo Li. Comparison of intestinal flora of diabetic and health adult in Dalian. World Chinese Journal of Digestology (Chinese), 2003; 11(6): 863-865
　　7．Yan Sun, Xuetuo Li, Xingju Yu. Determination of Sennoside (A+B) and Degraded products in the Process of Sennoside Metabolism by HPLC. Chromatogram (Chinese), 2004, 22 (1): 48-50
　　8．Bo Liu, Yan Sun, Yonghong Li, Zongbao Zhao. Progress on microbial glyceride biosynthesis and metabolic regulation in oleaginous microorganisms. Acta Microbiologica Sinica (Chinese), 2005, 45(1): 153-156
　　9．Yan Sun*, Lei Fu, Zhiqiang Xu, chongfei Xu, Qian Yang. Effect of Molecular Weight and Charge Ratio on the Stability of the Chitosan/DNA Complexes. Journal of biotechnology, 2008, 136S: S178
　　10．Yan Sun, Itziar Miguéliz, Gemma Navarro, Conchita Tros de Ilarduya. Structural and Morphological Studies of Cationic Liposomes-DNA Complexes. Letters in Drug Design & Discovery, 2009, 6(1): 33-37
　　11. Xianbin Liu, Yan Sun, Xiaojun Sun. “Synthesis of micron monodisperse mesoporous silica MCM-41 with shphrical porphology and applications”. Appl. No. CN 200910073248.X. 2009.11.23 (Chinese)
　　12．Shiyang Tang, Xiaojun Sun, Li Lin, Yan Sun*, Xianbin Liu. Monodisperse mesoporous silica nanoparticles: synthesis and application in biomaterials. Progress in Chemistry (Chinese), 2011, 23(9), 1973-1984
　　
　　International Conference
　　1．Yan Sun, Nejat Duzgunes, Sadao Hirota. Viscometry for determining shape parameter of DNA-lipid complex. 2nd International Congress on Drug Absorption Transport and Delivery. Poster, Hawaii, the United States, January 2003.
　　2．Yan Sun, Nejat Duzgunes, Yasuyuki Takaoka, Sho-ichi Ohi, Sadao Hirota. Viscometry for determining shape parameter of non-viral vectors. 3rd International symposium on gene delivery. Poster, Tokyo, Japan, May 2003, University of Tokyo.
　　3．Yan Sun*, Conchita Tros de Ilarduya. Characterizations of Plain Lipoplexes and Transferrin Lipoplexes as nanoparticles vectors for gene transfer. 13th International Biotechnology Symposium & Exhibition, October 2008, Dalian, China
　　4. Yan Sun *, Lei Fu, Lang Yuan, Chongfei Xu, Conchita Tros De Ilarduya. Preparation and Characterizations of Nanoparticles Vectors for Gene Transfer. The 26th annual convention of Chinese chemical society, July 2008, Tianjin, China
　　5. Yan Sun *, Chao Yang, Min Zheng, Qian Yang. Study of mesoporous silica nanoparticles on small DNA adsorption and release. 7th international symposium on biological control and bio-technology, Weihai, China, September 2009.
　　6．Zhiqiang Xu, Yan Sun *, Qian Yang. Optimization of fermentation medium constituents for the activity of CMCase using response surface methodology. 7th international symposium on biological control and bio-technology, Weihai, China, September 2009.
　　7．Xianbin Liu, Yan Sun *, Chao Yang, Jian Ma, Chunhui Shi, Qian Yang. Adsorptive removal of sulfanilamide, sulphamethazine and roxithromycin by mesoporous carbon. 7th international symposium on biological control and bio-technology, Weihai, China, September 2009.
　　8． Li Lin, Yan Sun *. The Cell Uptake of Mesoporous Silica Nanoparticles Carrying DNA in Vitro. 9th international symposium on biological control and bio-technology, Haikou, China, December 2011.
　　9．Tingsheng Yan, Yan Sun *. The Adsorption and Release of DNA by Mesoporous Silica Materials with Different Pore Diameters. 9th international symposium on biological control and bio-technology, Haikou, China, December 2011.
　　
　　科研项目
　　主持项目
　　1．国家自然科学基金青年项目（3090036）：“具有“门禁”，孔道修饰和形貌可控的介孔氧化硅纳米颗粒应用于siRNA靶向转染与控制释放的研究”
　　2．教育部博士点基金（20092302120070）：应用介孔氧化硅纳米颗粒介导siRNA靶向转染与控制释放
　　3．城市水资源与水环境国家重点实验室开放研究基金重点项目（QAK200809）：介孔纳米材料对微污染水体中抗生素的吸附研究
　　4．黑龙江省教育厅科学技术研究项目：新型基因载体介孔氧化硅材料的研究
　　5．哈尔滨市创新人才基金（2007RFLXS012）：抗肿瘤基因转运纳米载体的合成表征及机制研究
　　6．哈尔滨工业大学科研创新基金：配体修饰的纳米载体/基因复合物的形态学和转基因研究