2017年首都师范大学王海龙课题组考研调剂信息

　　首都师范大学生命科学学院DNA损伤应答实验室王海龙课题组可接受1-2个调剂生（2017）

　　要求报考985，211高校或中科院生物科学类专业。学术型硕士。考研分数过国家线要求。

　　我课题组研究方向为肿瘤发生的分子机制。主要关注DNA双链断裂修复的分子机制及与肿瘤发生、发展的关系。

　　有意向的同学请发送简历至whlpost@hotmail.com

　　王海龙

　　首都师大生科院副教授

　　2013-副教授首都师范大学生命科学学院

　　2008-2013博士后美国斯克利普斯研究所（TheScrippsResearchInstitute,LaJolla,California）

　　2002-2007博士北京师范大学生命科学学院生物化学与分子生物学专业

　　1995-1999本科北京师范大学生命科学学院生物化学与分子生物学专业

　　在研科研项目：

　　国家自然科学基金面上项目：CtIP的核酸酶活性及其参与DNA双链断裂修复的机制研究，80万，2014-2017(主持)

　　国家重大科学研究计划（973）子课题，DNA损伤响应重要蛋白维持基因组稳定性机制研究，123万元，2015-2019(主持)

　　北京市属高等学校青年拔尖人才培育计划，30万，2015-2017(主持)

　　发表文章:

Wang, H., Li, Y., Truong, L. N., Shi, L. Z., Hwang, P. Y., He, J., Do, J., Cho, M. J., Li, H., Negrete, A., Shiloach, J., Berns, M. W., Shen, B., Chen, L., and Wu, X. (2014) CtIP maintains stability at common fragile sites and inverted repeats by end resection-independent endonuclease activity. Molecular cell   54, 1012-1021. 5-year IF:15.3

　　Hailong Wang, Linda Z. Shi, Catherine CL Wong, Xuemei Han, Patty Yi-Hwa Hwang, Lan N. Truong, Qingyuan Zhu, Zhengping Shao, David J. Chen, Michael W. Berns, John R. Yates III, Longchuan Chen and Xiaohua Wu (2013). The interaction of CtIP and Nbs1 connects CDK and ATM to regulate HR-mediated double-strand break repair. Plos Genetics. 5-year IF:9.2

　　Wang, H., Shao, Z., Shi, L.Z., Hwang, P.Y., Truong, L.N., Berns, M.W., Chen, D.J., and Wu, X. (2012). CtIP dimerization is critical for its recruitment to chromosomal DNA double-strand breaks. The Journal of biological chemistry 5-year IF:5.1

　　Wang, H., Du, Y., Xiang, B., Lin, W., Li, X., and Wei, Q. (2008). A renewed model of CNA regulation involving its C-terminal regulatory domain and CaM. Biochemistry 47, 4461-4468. 5-year IF:3.3

　　Wang, H., Yao, S., Lin, W., Du, Y., Xiang, B., He, S., Huang, C., and Wei, Q. (2007). Different roles of Loop 7 in inhibition of calcineurin. Biochemical and Biophysical Research Communications 362, 263-268. 5-year IF:2.5

　　Wang, H.L., Du, Y.W., Xiang, B.Q., Lin, W.L., and Wei, Q. (2007). The regulatory domains of CNA have different effects on the inhibition of CN activity by FK506 and CsA. IUBMB Life 59, 388-393. 5-year IF:3.6

　　Peng, B., Wang, J., Hu, Y., Zhao, H., Hou, W., Zhao, H., Wang, H., Liao, J., and Xu, X. (2015) Modulation of LSD1 phosphorylation by CK2/WIP1 regulates RNF168-dependent 53BP1 recruitment in response to DNA damage. Nucleic acids research 43, 5936-5947

　　Makharashvili, N., Tubbs, A. T., Yang, S. H., Wang, H., Barton, O., Zhou, Y., Deshpande, R. A., Lee, J. H., Lobrich, M., Sleckman, B. P., Wu, X., and Paull, T. T. (2014) Catalytic and noncatalytic roles of the CtIP endonuclease in double-strand break end resection. Molecular cell 54, 1022-1033

　　Truong, L. N., Li, Y., Shi, L. Z., Hwang, P. Y., He, J., Wang, H., Razavian, N., Berns, M. W., and Wu, X. (2013) Microhomology-mediated End Joining and Homologous Recombination share the initial end resection step to repair DNA double-strand breaks in mammalian cells. Proceedings of the National Academy of Sciences of the United States of America 110, 7720-7725

　　Ye, Q., Wang, H., Zheng, J., Wei, Q., and Jia, Z. (2008). The complex structure of calmodulin bound to a calcineurin peptide. Proteins Structure Function and Bioinformatics 73, 19-27. 5-year IF:3.181

　　Ye, Q.L., Wang, H.L., Wong, A., Li, X., Wei, Q., and Jia, Z.C. (2007). Crystallization characteristics of calmodulin in complex and fused with calcineurin peptide. Cryst Growth Des 7, 2198-2201. 5-year IF:4.4

　　Yang, D.E., Lin, X.Y., Xiang, B.Q., Yang, Z.G., Wang, H.L., and Wei, Q. (2005). Structure-function relationship of chitosan against phytopathogenic fungi. Acta Chim Sinica 63, 1661-1665. 5-year IF:0.6

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