天津科技大学生物工程学院硕士生导师介绍：郭学武

　　个人简介

　　办公电话：************,022-606

　　电子邮件：guoxuewu@tust.edu.cn

　　通讯地址：天津经济技术开发区第十三大街29号天津科技大学生物工程学院

　　研究方向: [1]现代酿造技术与食品安全；[2]生物基化学品与合成生物学；[3]酵母生物学

　　招生专业

　　代表性论文

　　1. Zhong-Guan Sun，Meng-Qi Wang, Ya-Ping Wang, Shuang Xing, Kun-Qiang Hong, Ye-Fu Chen, Xue-Wu Guo*, Dong-Guang Xiao*, Identification by comparative transcriptomics of core regulatory genes for higher alcohol production in a top-fermenting yeast at different temperatures in beer fermentation, Applied Microbiology Biotechnology, 2019, doi:10.1007/s00253-019-09807-x

　　2. Mengqi Wang, Zhongguan Sun, Yaping Wang, Zhiyang Wei, Bingxu Chen, Huadong Zhang, Xuewu Guo*, Dongguang Xiao*, The effect of pitching rate on the production of higher alcohols by top-fermenting yeast in wheat beer fermentation, Annals of Microbiology，2019， doi: 10.1007/s13213-019-01463-w

　　3. Guo XW*, Zhang Y, Li LL, Guo J, Wu DG, Chen YF, Xiao DG, Improved xylose tolerance and 2,3-butanediol production of Klebsiella pneumoniae by directed evolution of rpoD and the mechanisms revealed by transcriptomics, Biotechnol Biofuels, 2018,11:307 doi: 10.1186/s13068-018-1312-8

　　4. Guo XW*,Wang YZ, Guo J, Wang Q, Zhang Y, Chen YF, Zhang CY, Xiao DG, Efficient production of 2,3-butanediol from cheese whey powder (CWP) solution by Klebsiella pneumoniae through integrating pulsed fed-batch fermentation with a two-stage pH control strategy, Fuel, 2017, 203: 469-477 DOI: 10.1016/j.fuel.2017.04.138

　　5. Li P, Guo X*, Shi T, Hu Z, Chen Y, Du L, Xiao D*. Reducing diacetyl production of wine by overexpressing BDH1 and BDH2 in Saccharomyces uvarum. J Ind Microbiol Biotechnol. 2017, 44(11):1541-1550. doi: 10.1007/s10295-017-1976-2.

　　6. Shi TT, Li P, Chen SJ, Chen YF, Guo XW*, Xiao DG*. Reduced production of diacetyl by overexpressing BDH2 gene and ILV5 gene in yeast of the lager brewers with one ILV2 allelic gene deleted. J Ind Microbiol Biotechnol. 2017, 44(3):397-405. doi: 10.1007/s10295-017-1903-6.

　　7. Guo XW#, Li YZ#, Guo J, Wang Q, Huang SY, Chen YF, Du LP, Xiao DG. Reduced production of ethyl carbamate for wine fermentation by deleting CAR1 in Saccharomyces cerevisiae. J Ind Microbiol Biotechnol. 2016, 43(5):671-679. doi: 10.1007/s10295-016-1737-7.

　　8. Guo X, Guan X, Wang Y, Li L, Wu D, Chen Y, Pei H, Xiao D. Reduction of biogenic amines production by eliminating the PEP4 gene in Saccharomyces cerevisiae during fermentation of Chinese rice wine. Food Chem. 2015, 178:208-211. doi: 10.1016/j.foodchem.2015.01.089.

　　9. Guo X, Cao C, Wang Y, Li C, Wu M, Chen Y, Zhang C, Pei H, Xiao D. Effect of the inactivation of lactate dehydrogenase, ethanol dehydrogenase, and phosphotransacetylase on 2,3-butanediol production in Klebsiella pneumoniae strain. Biotechnol Biofuels. 2014, 7(1):44. doi: 10.1186/1754-6834-7-44

　　10. Guo XW, Zhang YH, Cao CH, Shen T, Wu MY, Chen YF, Zhang CY, Xiao DG. Enhanced production of 2,3-butanediol by overexpressing acetolactate synthase and acetoin reductase in Klebsiella pneumoniae. Biotechnol Appl Biochem. 2014, 61(6):707-715. doi: 10.1002/bab.1217

　　11. Guo XW, Wang RS, Chen YF, Xiao DG, Intergeneric yeast fusants with efficient ethanol production from cheese whey powder solution: Construction of a Kluyveromyces marxianus and Saccharomyces cerevisiae AY-5 hybrid, Engineering in Life Sciences, 2012,12(6): 656-661 doi: 10.1002/elsc.201100112

　　12. Guo X, Zhou J, Xiao D. Improved ethanol production by mixed immobilized cells of Kluyveromyces marxianus and Saccharomyces cerevisiae from cheese whey powder solution fermentation. Appl Biochem Biotechnol. 2010,160(2):532-538. doi: 10.1007/s12010-008-8412-z.

　　主要著作

　　参编：《发酵工程实验教程》；《生物工程专业实验》等。

　　科研项目

　　[1] 国家自然科学基金项目：高核酸酿酒酵母RNA合成的分子遗传机制研究，31671834，主持

　　[2] 国家自然科学基金项目：全局转录因子σ定向进化提高肺炎克雷伯氏菌发酵木糖生产2,3-丁二醇能力的研究及其调控机理，21406168，主持

　　[3] 中国博士后科学基金面上项目：放线菌在白酒生产中的作用及其机制研究，2017M611169，主持

　　[4] 河北省博士后择优支持项目：白酒中萜烯类物质的研究，B2018003031，主持

　　[5] 天津市应用基础及前沿技术研究计划：适量高产酯酿酒酵母优良基因工程菌种的选育，12JCQNJC06500、主持

　　[6] 国家科技支撑项目子课题：食品安全朔源控制及预警技术研究与推广应用示范---酵母安全生产与质量控制，主持

　　[7] 横向课题：安徽文王酿酒股份有限公司菌种鉴定与相关标准制定，主持

　　其他（获奖成果、专利）等

　　研究成果分别获得2017和2016年中国轻工业联合会科技进步二等奖， 2014年中国轻工联合会科学技术优秀奖；2010年中国食品协会技术进步一等奖和中国轻工业联合会科技进步二等奖；先后申请专利40余项，其中授权中国发明专利30余项。