天津科技大学生物工程学院硕士生导师介绍：崔建东

　　个人简介

　　办公电话：

　　电子邮件：jdcui@tust.edu.cn

　　通讯地址：天津经济技术开发区第十三大街29号天津科技大学生物工程学院

　　研究方向: [1]纳米生物催化与转化 [2]药用蛋白颗粒化制备技术 [3]人工纳米包衣的理性设计 [4]食品防腐

　　招生专业

　　代表性论文

　　先后发表SCI收录论文50篇，他引500多次。

　　[1] Jiandong Cui*, Sizhu Ren, Baoting Sun, Shiru Jia. Optimization protocols and improved strategies of metal–organic frameworks for immobilizing enzymes: current development and future challenges. Coordination Chemistry Reviews(JCR一区, IF14.499), 2018, 370, 22-41.

　　[2] Sizhu Ren, Conghai Li, Zhilei Tan, Ying Hou, Shiru Jia, Jiandong Cui*. Carbonic anhydrase-embedded ZIF-8 hydrogel membrane with improved the recycling and stability for efficient CO2 capture. Journal of Agricultural and Food Chemistry (JCR一区, IF3.412), 2019, 67, 3372-3379.

　　[3] Jiandong Cui*, Sizhu Ren, Tao Lin, Yuxiao Feng, Shiru Jia. Shielding effects of Fe3+-tannic acid nanocoatings for immobilized enzyme on magnetic Fe3O4@silica core shell nanosphere. Chemical Engineering Journal (JCR一区, IF6.735), 2018, 343, 629-637.

　　[4] Jiandong Cui*, Yuxiao Feng, Shiru Jia. Silica encapsulated enzyme@metal-organic framework composite: a highly stable and recyclable biocatalyst. Chemical Engineering Journal (JCR一区, IF6.735), 2018, 351, 506-514.

　　[5] Hongjie Bian, Baoting Sun, Jiandong Cui*, Sizhu Ren, Tao Lin, Yuxiao Feng, Shiru Jia. Bienzyme magnetic nanobiocatalyst with Fe3+-tannic acid film for one pot starch hydrolysis, Journal of Agricultural and Food Chemistry (JCR一区, IF3.412), 2018, 66, 8751-8760.

　　[6] Jiandong Cui*, Shiru Jia. Organic–inorganic hybrid nanoflowers: a novel host platform for biomolecules immobilization. Coordination Chemistry Reviews(JCR一区, IF14.499), 2017, 352, 249-263.

　　[7] Jiandong Cui*, Yuxiao Feng, Tao Lin, Zhilei Tan, Cheng Zhong, Shiru Jia. Mesopores metal-organic framework with well-defined cruciate like-flower morphology for enzyme immobilization. ACS Applied Materials & Interfaces (JCR一区, IF8.097), 2017, 9(12), 10587-10594.

　　[8] Jiandong Cui*, Yamin Zhao, Yuxiao Feng, Tao Lin, Cheng Zhong, Zhilei Tan, Shiru Jia*. Encapsulation of spherical cross-linked phenylalanine ammonia lyase aggregates in mesoporous biosilica, Journal of Agricultural and Food Chemistry (JCR一区, IF3.412), 2017, 65, 618-625.

　　[9] Jiandong Cui*, Zhilei Tan, Peipei Han, Cheng Zhong, Shiru Jia. Enzyme shielding in large mesoporous hollow biosilica shell for improved the recycling and stability based on CaCO3 microtemplates and biomimetic silicification. Journal of Agricultural and Food Chemistry (JCR一区, IF3.412), 2017, 65(19), 3883-3890.

　　[10] Jiandong Cui, Lili Cui, Shiru Jia, Zhiguo Su, Songping Zhang*. Hybird cross-linked lipase aggregates with magnetic nanoparticles: a robust and recyclable biocatalysis for epoxidation of oleic acid. Journal of Agricultural and Food Chemistry (JCR一区, IF3.412), 2016, 64(38), 7179-7187.

　　[11] Jiandong Cui*. Biotechnological production and applications of Cordyceps militaris, a valued traditional Chinese medicine, Critical Reviews in Biotechnology (JCR一区, IF 5.239), 2015, 35(4), 475-484.

　　[12] Jiandong Cui*, Shiru Jia. Optimization protocols and improved strategies of cross-linked enzyme aggregates technology: current development and future challenges. Critical Reviews in Biotechnology (JCR一区, IF 5.239), 2015, 35(1), 15-28.

　　[13] Jiandong Cui*, Jiqing Qiu, Xianwei Fan, Shiru Jia, Zhilei Tan. Biotechnological production and applications of microbial phenylalanine ammonia lyase: a recent review, Critical Reviews in Biotechnology (JCR一区, IF 5.239), 2014, 34 (3), 258-268.

　　[14] Jiandong Cui*, Yamin Zhao, Ronglin Liu, Shiru Jia. Surfactants activated lipase hybrid nanoflowers with dramatically enhanced enzymatic performance. Scientific Reports (JCR一区, IF 4.122), 2016, 6, 27928.

　　[15] Jiandong Cui*, Shiru Jia, Longhao Liang, Yamin Zhao, Yuxiao Feng. Mesoprous CLEAs-silica composite microparticles with high activity and enhanced stability, Scientific Reports (JCR一区, IF 4.122), 2015, 5, 14203.

　　[16] Jiandong Cui*, Jiqing Qiu. Production of extracellular water insoluble polysaccharide from Pseudomonas sp. Journal of Agricultural and Food Chemistry (JCR一区, IF3.412), 2012, 10, 4865-4871.

　　[17] Bingzhu Zhang, Jiandong Cui*. Modeling and optimization of phenylalanine ammonia lyase stabilization in recombinant Escherichia coli for the continuous synthesis of L-phenylalanine on the statistical-based experimental designs. Journal of Agricultural and Food Chemistry(JCR一区, IF3.412), 2010, 58, 2795-2800.

　　[18] Jiandong Cui*, Baoting Sun, Tao Lin, Yuxiao Feng, Shiru Jia. Enzyme shielding by mesoporous organosilica shell on Fe3O4@silica yolk-shell nanospheres. International Journal of Biological Macromolecules (JCR二区, IF 3.909), 2018,117, 673-682.

　　[19] Sizhu Ren, Yuxiao Feng, Huan Wen, Conghai Li, Jiandong Cui*, Shiru Jia. Immobilized carbonic anhydrase on mesoporous cruciate flower-like metal organic framework for promoting CO2 sequestration. International Journal of Biological Macromolecules (JCR二区, IF 3.909), 2018,117, 189-198.

　　[20] Zhilei Tan, Tao Bo, Fengzhu Guo, Jiandong Cui*, Shiru Jia. Effects of ε-Poly-L-lysine on the cell wall of Saccharomyces cerevisiae and its involved antimicrobial mechanism, International Journal of Biological Macromolecules (JCR二区, IF3.909), 2018, 118, 2315-2323.

　　[21] Jiandong Cui*, Tao Lin, Yuxiao Feng, Zhilei Tan, Shiru Jia. Preparation of spherical cross-linked lipase aggregates with improved activity, stability and reusability characteristric in water-in-ionic liquid microemulsion, Journal of Chemical Technology and Biotechnology (JCR二区, IF 2.587), 2017, 92(7), 1785-1793.

　　[22] Muhammad Bilal, Tahir Rasheed, Yuping Zhao, Hafiz M. N. Iqbal, Jiandong Cui* “Smart” chemistry and its application in peroxidase immobilization using different support materials, International Journal of Biological Macromolecules (JCR二区, IF3.909), 2018, 119, 278-290.

　　[23] Jiandong Cui*, Yamin Zhao, Cheng Zhong, Zhilei Tan, Peipei Han, Shiru Jia. Mesoporous phenylalanine ammonia lyase microspheres with improved stability through calcium carbonate templating. International Journal of Biological Macromolecules (JCR二区, IF3.909), 2017, 98, 887-896.

　　[24] Jiandong Cui*, Hongbao Li, Jianquan Luo, Weifeng Cao, Changsheng Qiao, Yinhua Wan. One step separation of Aureobasidium pullulans from β-poly(L-malic acid) fermentation broth by membranes technology, Journal Chemical Technology and Biotechnology (JCR二区, IF2.587), 2017, 92(4), 845-853.

　　[25] Jiandong Cui*, Yuxiao Feng, Shu Yue, Yamin Zhao, Linbo Li, Ronglin Liu, Tao Lin. Magnetic mesoporous enzyme-silica composites with high activity and enhanced stability, Journal Chemical Technology and Biotechnology (JCR二区, IF2.587), 2016, 91, 6, 1905-1913.

　　[26] Jiandong Cui*, Lianlian Li, Yamin Zhao. Simple technique for preparing stable and recyclable cross-linked enzyme aggregates with crude-pored microspherical silica core. Industrial & Engineering Chemistry Research (JCR一区, IF3.141), 2014, 53(42), 16176-16182.

　　[27] Jiandong Cui*, Lili Cui, Songping Zhang. Hybrid magnetic cross-linked enzyme aggregates of phenylalanine ammonia lyase from Rhodotorula glutinis. PLoS ONE (IF 2.766), 2014. 9(5), e97221.

　　[28] Jiandong Cui*, Lianlian Li, Hongjie Bian. Immobilization of cross-linked phenylalanine ammonia lyase aggregates in microporous silica gel, PLoS ONE (IF 2.766), 2013, 8(1), e53542.

　　[29] Jiandong Cui*, Ronglin Liu, Linbo Li. A facile technique to prepare cross-linked enzyme aggregates of bovine pancreatic lipase using bovine serum albumin as an additive, Korean Journal of Chemical Engineering (JCR二区, IF 2.199), 2016. 33(2), 610-615.

　　[30] Jiandong Cui*, Longhao Liang, Cong Han, Ronglin Liu. Stabilization of phenylalanine ammonia lyase from Rhodotorula glutinis by encapsulation in polyethyleneimine-mediated biomimetic silica, Applied Biochemistry and Biotechnology (IF 1.797), 2015, 176, 999-1011.

　　[31] Jiandong Cui*, Limei Sun, Lianlian Li. A simple technique of preparing stable CLEAs of phenylalanine ammonia lyase using co-aggregation with starch and bovine serum albumin, Applied Biochemistry and Biotechnology (IF 1.797), 2013, 170(8), 1827-1837.

　　[32] Si Zhang, Jiandong Cui*. Enhancement of phenylalanine ammonia lyase production from Rhodotorula mucilaginosa by optimization of culture conditions in batch and fed-batch, Biotechnol Biotec Eq (IF 1.227), 2012, 6, 3418-3423.

　　[33] Jiandong Cui*, Yanan Zhang. Evaluation of metal ions and surfactants effect on cell growth and exopolysaccharide production in two-stage submerged culture of Cordyceps militaris, Applied Biochemistry and Biotechnology (IF 1.797), 2012, 168, 1394-1404.

　　[34] Jiandong Cui*, Si Zhang, Limei Sun. Cross-linked enzyme aggregates of phenylalanine ammonia lyase: novel biocatalysts for synthesis of L-phenylalanine, Applied Biochemistry and Biotechnology (IF 1.797), 2012, 167, 835–844.

　　[35] 崔建东, 李莹, 姬晓元, 边红杰，张羽飞, 苏志国, 马光辉, 张松平. 静电纺丝制备中空纤维原位固定化碳酸酐酶用于二氧化碳的吸收, 高等学校化学学报, 2014, 35,1999-2006(封面文章).

　　[36] 崔建东, 崔兆惠, 苏志国, 郑春阳, 马光辉, 张松平. 生物3D打印蓖麻油基水性聚氨酯涂层固定碳酸酐酶研究, 化工学报, 2018, 69(8),3577-3584(封面文章).

　　主要著作

　　[1] 李艳主编《发酵工业概论》第二版，2011，参编第二章和第六章

　　[2] 贾士儒主编《生物工程专业实验》第二版，2011，参编

　　科研项目

　　[1]印迹交联酶聚体-离子液体-介孔氧化硅杂化催化剂的制备及其在不同介质

　　中的催化性能，国家自然基金面上项目(21676069)，2017-2020，主持。

　　[2]天津市特聘教授科研经费，2018-2022，主持。

　　[3]天津科技大学海河学者特聘教授科研经费，2017-2020，主持。

　　[4]金属-有机骨架（MOFs)形貌结构的理性调控及其在固定化酶捕集转化CO2中的应用基础研究，河北省自然基金面上项目(B2018208041)，2018-2020，主持。

　　[5]基于有机金属骨架（MOFs)酶的固定化及其在CO2捕集转化中的应用基础研究，河北省百名优秀创新人才(III)资助项目(SLRC2017036)，2017-2020，主持。

　　[6]新型磁性交联酶聚体的制备、表征及其催化性能研究，河北省高层次人才工程资助项目，2014-2016，主持。

　　[7]基于离子液体修饰的新型酶固载催化体系的建立及其催化性能研究，河北省自然基金面上项目(B2014208054)，2014-2016，主持。

　　[8]生物法生产长链二元酸关键技术开发及应用示范，国家863项目(2015AA021002)，2015-2017，主研。

　　[9]一步酶法转化CO2促进发菜细胞生长的研究，工业发酵微生物教育部重点实验室开放基金(2016IM001)，2016-2018，主持。

　　[10]基于印迹交联酶聚体技术酶活性构象的“复制”及其催化活性研究，国家自然科学基金面上项目(21072041)，2011-2013，主持。

　　[11]苯丙氨酸解氨酶活性构象的“刻录”、表征及其催化活性研究，中国科学院过程工程研究所生化工程国家重点实验室开放基金(2010KF-12)，2010-2013，主持，

　　[12]名贵中药-冬虫夏草菌两阶段高密度液体深层培养关键技术创新研究，河北省高等学校科学技术研究项目，2010128，2010-2012，主持。

　　其他（获奖成果、专利）等

　　专利

　　[1]    北冬虫夏草多糖两阶段发酵合成工艺，国家发明专利，授权号ZL 201110134499.1

　　[2]    一种以微孔硅胶为内核的苯丙氨酸解氨酶交联酶聚体的制备方法，国家发明专利，授权号ZL201410149245.0。

　　获奖情况

　　2016年被美国化学会授予“Three-year American Chemical Society membership award”和“Certificate of Appreciation for Valuable Contribution and Dedicated Service in the Peer Review (Outstanding Reviewer Award) ”。2019年国际埃尼奖提名。

　　指导的2015、2016和2017级研究生连续三届获得国家奖学金、优秀研究生奖学金、一等研究生学业奖学金和一等研究生学业优秀奖学金。两人获得河北省优秀硕士论文。