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山东大学生命科学学院导师介绍:石梅


  石梅 副教授
  硕士生导师,博士
  电话:*************;*************
  E-mail:clubstone@sdu.edu.cn
   
  教育和工作经历
  主要研究方向:木霉微生物学
  2006.9~至今 山东大学微生物技术国家重点实验室:副教授
  2000.9 ~2006.7 山东大学生命科学学院:发育学博士,讲师
  1994.9~2000.7 山东大学西校区卫生部耳鼻喉实验室:助理研究员
  1991.9~1994.7 山东师范大学生命科学院:遗传学硕士
   
  近期发表的学术论文
  1. Shi M, Wang HN, Xie ST, Luo Y, Sun CY, Chen XL, Zhang YZ. Antimicrobial peptaibols, novel suppressors of tumor cells, targeted calcium-mediated apoptosis and autophagy in human hepatocellular carcinoma cells. Mol. Cancer 2010,9:26-41 (2009 Impact foctor: 4.416)
  2. Luo Y, Zhang DD, Dong XW, Zhao PB, Chen LL, Song XY, Wang XJ, Chen XL, Shi M, Zhang YZ. Antimicrobial peptaibols induce defense responses and systemic resistance in tobacco against tobacco mosaic virus. FEMS Microbiol. Lett. 2010, 313:120-6 (2009 Impact foctor: 2.199).
  3. Shi M, Yan SG, Xie ST, Wang HN. Tip30-induced apoptosis requires translocation of Bax and involves mitochondrial release of cytochrome c and Smac/DIABLO in hepatocellular carcinoma cells. Biochim. Biophys. Acta. 2008, 1783:263-74(2008 Impact foctor:4.89).
  4. Chen LL, Liu LJ, Shi M, Song XY, Zheng CY, Chen XL, Zhang YZ. Characterization and gene cloning of a novel serine protease with nematicidal activity from Trichoderma pseudokoningii SMF2. FEMS. Microbiol. Lett. 2009, 299:135-42. (2009 Impact foctor: 2.199)
  5. Jian Zhao, Xia Zhang, Mei Shi, Hao Xu, Jun Jin, Haidong Ni, Silei Yang, Jianxin Dai, Mengchao Wu, and Yajun Guo. TIP30 inhibits growth of HCC cell lines and inhibits HCC xenografts in mice in combination with 5-FU. Hepatology 2006, 44:205-15(2006 Impact foctor: 10.446).
  6. Jin J, Zhao J, Zhang X, Shi M, Guo YJ. Transfection of Smac sensatizes tumor cells to etoposide-induced apoptosis in vitro and eradiates established human hepatoma in vivo. Cancer Gene therapy, 2006, 13:420-7(2006 Impact foctor: 4.187)
  7. Dong XW, Song XY, Shi M, Zhang YZ. Study on conformation transitions of trichokonin VI, a peptaibol-like antimicrobial peptide, in different solvents by circular dichroism spectroscopy. Guang Pu Xue Yu Guang Pu Fen Xi. 2010 ,30:458-61.
  8. He Q, Zhu X, Shi M, Zhao B, Zhao J, Zhang S, Miao J. Novel morpholin-3-one derivatives induced apoptosis and elevated the level of P53 and Fas in A549 lung cancer cells. Bioorg. Med. Chem. 2007, 15:3889-95 (2007 Impact foctor: 2.66).
  9. Xiao-Yan Song, Shu-Tao Xie, Xiu-Lan Chen,Cai-Yun Sun, Mei Shi, Yu-zhong Zhang.Solid-state fermentation for Trichokonins production fromTrichoderma koningii SMF2 and preparative purification of Trichokonin VI by a simple protocol. J. Biotech. 2007, 131: 209–215 (2007 Impact foctor: 2.6).
  10. Shi M, Zhang X, Wang P, Zhang HW, Zhang BH, Wu MC. TIP30 regulates the expression of apoptosis-related genes in human hepatocellular carcinoma cells undergoing p53-mediated apoptotic signal introduction pathway. World J. of Gastroenterology. 2005,11:221-227(2005 Impact foctor: 3.308)

  承担课题
  1. 抗肿瘤抗生素肽peptaibols诱导肿瘤细胞自噬性死亡的靶向作用机制研究国家自然科学基金委,33万元,2011-2013。
  2. 海洋真菌康宁木霉生物农药及其合成的peptaibols类新型农用抗生素——康宁霉素的中试研究,国家海洋863,191万元,2007-2010。
  3. 康宁木霉合成的peptaibols类抗生素肽结构、性质及其抗肿瘤机理研究,国家自然科学基金委,2009-2011,33万元。
  4. 离子通道类抗肿瘤抗生素诱导肿瘤细胞凋亡和自噬的机理研究,山东省博士基金,2009-2012,5万元。
  5. 重组复制缺陷型integrin-beta4腺病毒与TIP30联合治疗肿瘤的研究,山东省博士基金,2006-2008,6万元,已结题。

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