山东大学生命科学学院导师介绍：陈敏

　　陈敏 副教授 博士
　　通讯地址：250100，山东大学 生命科学学院 微生物技术国家重点实验室糖科学技术实验室
　　联系方式：*************
　　E-mail: chenmin@sdu.edu.cn
　　
　　研究方向
　　微生物糖生物学和糖生物化学
　　
　　研究项目
　　曾先后承担或参加项目5项(其中2项参加人，3项主持人) , 主持横向课题一项。基于转基因植物的大肠杆菌志贺氏毒素口服疫苗研究 (山东省医药卫生科研项目, 2007—2009，课题主持人)。干扰素-β的糖基化改造研究(山东省优秀中青年科学家科研奖励基金, 2005-2007，课题主持人), 细胞色素P450和谷胱甘肽-S-转移酶基因共表达农药降解基因工程菌的研究( 国家高技术研究发展计划（863计划），2008-2010, 子课负责人), 糖基化改造的干扰素-β研究与应用(横向课题, 2005-2007, 课题主持人),糖生物学I－糖酰胺酶的研究与应用(30470399))(国家自然科学基金, 2004-2007, 主要参加人), 利用化学生物酶法合成岩藻糖基化寡糖及其水凝胶聚合物在医学中的应用(20572063) (国家自然科学基金, 2005-2008, 主要参加人) 。
　　
　　申请专利
　　1.钠/质子反向转运器基因及其编码的蛋白质，专利号: 02146310
　　2.用酵母表达、生产及糖基化改造人干扰素－β的方法,专利申请号: 200510045207.1
　　
　　近年发表论文：
　　1．Zhong Zhuang, Zhi-Gang Wu, Min Chen* and Peng George Wang.Secretion of human interferon-B 1b by recombinant Lactococcus lactis, Biotechnology Letters (2008), 30(10), 1819-1823.
　　2．Jie Shen, Robert Woodward, James Patrick Kedenburg, Xianwei Liu, Min Chen, Lanyan Fang, Duxin Sun, and Peng George Wang，Histone Deacetylase Inhibitors through Click Chemistry，J. Med. Chem., 2008, 51 (23), 7417-7427
　　3．Min. Chen, Qi.-Jun. Chen, Xu.-Guang. Niu, Rong. Zhang, Hui.-Qiong. Lin, Chun.-Ying. Xu, Xue.-Chen. Wang, Gou.-Ying. Wang, Ja. Chen, Expression of OsNHX1 gene in maize confers salt tolerance and promotes plant growth in the field，PLANT SOIL ENVIRON. 2007,53, (11): 490–498
　　4．zhao, Guohui; Liu, Jun; Liu, Xiang; Chen, Min; Zhang, Houcheng; Wang, Peng George. Cloning and characterization of GDP-perosamine synthetase (Per) from Escherichia coli O157 :H7 and synthesis of GDP-perosamine in vitro. Biochemical and Biophysical Research Communications , 2007, 363(3), 525-530.
　　5．Su, Yishan; Zhang, Houcheng; Gu, Li; Chen, Min; Xiao, Min; Wang, Peng George; Qi, Qingsheng. Engineered yeast with PNGase F on cell surface for releasing of N-glycans from glycoproteins. Enzyme and Microbial Technology (2007), 40(6), 1496-1502.
　　6．Wang Qing jie , Li Lei, Chen M, Qi Qingsheng, Wang Peng George.Construction of a novel system for cell surface display of heterologous proteins on Pichia pastoris，Biotechnol Lett. 2007, 29(10):1561-6.
　　7 ．Jing Li, Min Chen*, Xian-Wei Liu, Hou-Cheng Zhang, Fa Fu Shen, Peng George Wang, Transient expression of an active human interferon-beta in lettuce, Scientia Horticulturae, 2007,112:258–265
　　8．Jing Li; Min Chen*; Xianwei Liu; Fafu Shen, Peng George Wang *, A Highly Efficient System Establishment of Transient Expression in Lettuce, Acta Horticulturae Sinica, 2006, 33 (2) : 405～407 (in Chinese)
　　9．Jing Song, Kang Ryu, Min Chen, Wei Wang , Hanfen Li , Wen Yi , Peng George Wang，Enzymatic Biosynthesis of Oligosaccharides and Glycoconjugates，Current Organic Synthesis, 2006, 3, 19-39.
　　10．Yu-Ye Wu, Qi-Jun Chen, Min Chen, Jia Chen and Xue- Chen Wang ，Salt-tolerant transgenic perennial ryegrass (Lolium perenne L.) obtained by Agrobacterium tumefaciens-mediated transformation of the vacuolar Na+/H+ antiporter gene, Plant Science, 2005, 169(1): 65-73
　　11．Min Chen, Xianwei Liu, Zhankun Wang, Qingsheng Qi, Peng George Wang, Modification of plant N-glycans processing—The Future of Producing Therapeutic Protein by Transgenic Plants, Medicinal Research Reviews, 2005, 25(3):343-360
　　12．Min Chen, Qi-Jun Chen, Mao feng Cai, Guo ming Shen, Jia Chen and Xue- Chen Wang, Cloning and characterization of Na+/H+ antiporter gene in zea mays，2005，High technology letter, 15(169):62-65 (in Chinese)
　　13．Min Chen, Dehu Liu, Peng George Wang ,Progresses in glycosylation of transgenic plants and the strategies for Modifying N-glycans of glycoproteins, High technology letter, 2005,15(172):107-110 (in Chinese)

　　* Corresponding author
　　Book
　　Ryu, Kang; Lin, Steven; Shao, Jun; Song, Jing; Chen, Min; Wang, Wei; Li, Hanfen; Yi, Wen; Wang, Peng George. “Synthesis of complex carbohydrates and glyconjugates: Enzymatic synthesis of globotetraose using ?-1,3-N-acetylgalactosaminyltransferase LgtD from Haemophilus infuenzae strain Rd.” Methods in Molecular Biology (Totowa, NJ, United States) 2005, 310(Chemical Genomics), 93-105.

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