山东大学生命科学学院导师介绍：刘祖国

　　刘相国 教授
　　博士生导师
　　电话:*************
　　E-mail:xgliu@sdu.edu.cn
　　 
　　教育背景
　　中国科学院微生物研究所 理学博士学位（微生物学），2000
　　山东大学生命科学学院 理学硕士学位（细胞生物学），1997
　　山东大学生物系 理学学士学位（生物学），1994
　　 
　　工作经历
　　2008.8-现在, 细胞生物学教授,博士生导师,学术带头人(第二层次),山东大学生命科学学院
　　2003.9-2008.8, postdoctoral fellow，Department of Hematology/Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA , USA
　　2002.11-2003.8, postdoctoral associate，Department of Molecular Genetics and Microbiology ,College of Medicine, University of Florida, Gainesville, FL, USA.
　　2000.9-2002.11,博士后,北京大学医学部基础医学院免疫系。
　　
　　研究方向
　　肿瘤细胞信号转导和抗肿瘤药物筛选:
　　本研究组将以中国人高发肿瘤为研究对象，充分利用分子生物学，基因组学及蛋白质组学等技术，研究肿瘤细胞发生、发展和转移的分子机理；肿瘤细胞死亡的分子机制及信号转导；抗肿瘤药物的作用机制及抗肿瘤靶向药物筛选系统的构建等。
　　
　　研究成果及发表论文
　　近年发表论文
　　1.Lin YD*，Liu X*, Yue P, Khuri FR, Sun SY. Involvement of c-FLIP and survivin downregulation in Flex-Het-induced apoptosis and enhancement of TRAIL-initiated apoptosis in lung cancer cells. Molecular Cancer Ther. 2008. 7(11): 3556-3565. (*indicating authors of equal contribution).
　　2.Liu X, Yue P, Chen S, Hu L, Lonial S, Khuri FR, Sun SY. The Proteasome Inhibitor PS-341 (Bortezomib) Up-Regulates DR5 Expression Leading to Induction of Apoptosis and Enhancement of TRAIL-Induced Apoptosis Despite Up-Regulation of c-FLIP and Survivin Expression in Human NSCLC Cells. Cancer Res. 2007 May 15;67 (10):4981-8.
　　3.Liu X, Yue P, Schonthal AH, Khuri FR, Sun SY. Cellular FLICE-inhibitory protein down-regulation contributes to celecoxib-induced apoptosis in human lung cancer cells. Cancer Res. 2006 Dec 1; 66(23):11115-9.
　　4.Liu X, Yue P, Khuri FR, Sun SY. Decoy receptor 2 (DcR2) is a p53 target gene and regulates chemosensitivity. Cancer Res. 2005. Oct 15; 65(20): 9169-75.
　　5.Liu X, Yue P, Zhou Z, Khuri FR, Sun SY. Death receptor regulation and celecoxib-induced apoptosis in human lung cancer cells. J Natl Cancer Inst. 2004 Dec 1; 96(23): 1769-80.
　　6.Liu X, Yue P, Khuri FR, Sun SY. p53 upregulates death receptor 4 expression through an intronic p53 binding site. Cancer Res. 2004 Aug 1; 64(15): 5078-83.
　　7.Jin F*, Liu X*, Zhou Z, Yue P, Lotan R, Khuri FR, Chung LW, Sun SY. Activation of nuclear factor-kappaB contributes to induction of death receptors and apoptosis by the synthetic retinoid CD437 in DU145 human prostate cancer cells. Cancer Res. 2005 Jul 15; 65(14):6354-63. (*indicating authors of equal contribution)
　　8.Sun SY, Liu X, Zou W, Yue P, Marcus AI, Khuri FR. The farnesyltransferase inhibitor Lonafarnib induce CHOP-dependent expression of death receptor 5 leading to induction of apoptosis in human cancer cells. J Biol Chem. 2007 Jun 29; 282(26):18800-9. Epub 2007 May 9.
　　9.Qiu Y, Liu X, Zou W, Yue P, Lonial S, Khuri FR, Sun SY. The Farnesyltransferase Inhibitor R115777 Up-regulates the Expression of Death Receptor 5 and Enhances TRAIL-Induced Apoptosis in Human Lung Cancer Cells. Cancer Res. 2007 May 15; 67(10):4973-80.
　　10.Zou W, Liu X, Yue P, Zhou Z, Sporn MB, Lotan R, Khuri FR, Sun SY. c-Jun NH2-terminal kinase-mediated up-regulation of death receptor 5 contributes to induction of apoptosis by the novel synthetic triterpenoid methyl- 2-cyano– 3 ,12-dioxooleana-1, 9-dien-28-oate in human lung cancer cells. Cancer Res. 2004 Oct 15; 64(20): 7570-8.
　　11.Chang LJ, Liu X, He J. Lentiviral siRNAs targeting multiple highly conserved RNA sequences of human immunodeficiency virus type 1.Gene Ther. 2005 Jul; 12(14):1133-44.
　　12.Chen S, Liu X, Yue P, Schonthal AH, Khuri FR, Sun SY. CHOP-dependent DR5 induction and ubiquitin/proteasome-mediated c-FLIP downregulation contribute to enhancement of TRAIL-induced apoptosis by dimethyl- celecoxib in human non-small cell lung cancer cells. Mol Pharmacol. 2007 Nov;72(5):1269-79. Epub 2007 Aug 7.
　　13.Zou W, Liu X, Yue P, Khuri FR, Sun SY. PPARgamma Ligands Enhance TRAIL-induced Apoptosis through DR5 Upregulation and c-FLIP Downregulation in Human Lung Cancer Cells. Cancer Biol Ther. 2007 Jan 29;6(1);6(1):99-106.
　　14.Zou W, Chen S, Liu X, Yue P, Sporn MB., Khuri FR. and Sun SY. c-FLIP Downregulation Contributes to Apoptosis Induction by the Novel Synthetic Triterpenoid Methyl-2-cyano-3, 12-dioxooleana-1, 9-dien-28-oate (CDDO- Me) in Human Lung Cancer Cells. Cancer Biol Ther. 2007 Oct; 6(10).
　　15.Zhang XY, Liu XG, Wang W, Wang WC, Gao XM. Anti-T-cell humoral and cellular responses in healthy BALB/c mice following immunization with ovalbumin or ovalbumin-specific T cells. Immunology. 2003; 108 (4): 465 – 473.
　　16.Zhao WP, Liu XG, Wang W, Gao XM. Large quantity of ribosomal RNA exists extracellularly in mouse spleen. Histochem J. 2002, Aug-Sep; 34(8-9): 391-6.
　　17.Yang G, Qiu B, Liu X, Li Y, Wang X. Nonsense mutations of replicase and movement protein genes contribute to the attenuation of an avirulent tomato mosaic virus. Virus Res. 2002; 87 (2): 119-128.
　　18.Liu XG, Wang W, Lu Y, Gao XM. T cell vaccination induces regulatory humoral immune response in BALB/c mice. Chin J Immunol. (中国免疫学杂志). 2002, 18(9): 604-607.
　　19.Liu XG, Yang G, Qiu BS, Tien P. Construction of fusion gene of HBV (adr) surface antigen determinant and B subunit of Cholera toxin and high level expression in E.coli. Acta Microbiologica Sinica.（微生物学报）, 2001, 41(5): 625- 629.
　　20.Liu XG,Yang G, Qiu BS, Tien P. Expression of two truncated enhancin gene from Helicoverpa armigera granulosis virus in E.coli. and its preliminary bioassay, Acta Microbiologica Sinica.（微生物学报）. 2001, 41(2): 167-172.
　　21.Liu XG, Yang G, Qiu BS, Tien P. Removing unspecific antibodies with sephacryl gel coupling E.coli. proteins by periodate oxidation. Microbiologica. （微生物学通报）. 2001, 28(3):73-75.
　　22.Liu XG, Yang G, Qiu BS, Tien P. Molecular cloning of enhancin gene from Helicoverpa armigera granulosis virus and its expression in E.coli. Acta Microbiologica Sinica.（微生物学报）.2000, 40(4):379-383.
　　23.Yang G, Liu XG, Qiu BS. Complete nucleotide sequences and structure analysis of the infectious cDNAs of tobacco mosaic virus (Chinese isolate, vulgar strain) and its attenuated vaccine-N14 (tomato strain) genomes. Chin. J. Biotech.（生物工程学报）。.2000. 16(4):437-442.
　　24.Yang G, Liu XG, Qiu BS, Recombinants construction and infectivity analysis of tobacco mosaic virus and attenuated tomato mosaic virus N14 genomes. Chinese sciences bulletin.（科学通报）. 2000, 45(15):1399- 1404.
　　25.Zhao WP Liu XG, Wang W, Lv P Zhang L, Gao XM. Relationship Between RNA Released from Mouse Apoptotic Murine Splenocytes and Autoimmune Disease. Chinese Journal of Biochemistry and Molecular Biology.（中国生物化学和分子生物学杂志） 2003,19(5): 662-666.
　　26.Zhang XY, Han SH, Liu XG, Gao XM, et al. T cell vaccination induces regulatory T cell response in BALB/c mice. Chin J Microbiol Immunol.（中华微生物学免疫学杂志） 2002, 22(2):127-130.
　　27.Li B, Han SH, Liu XG, Gao XM.T cell vaccination against systemic lupus erythematosus in BXSB mice. Acad J Sec Mil Med Univ. （第二军医大学学报）2002, 23(10): 1091-1096.

　　综述性文章
　　1.Liu X, Sun SY. FLICE Inhibitory protein. In: Encyclopedia of Cancer (Second Edition). 2008.1131-1133. Springer Berlin Heidelberg. ISBN：978-3-540-36847-2 (Print) 978-3-540-47648-1 (Online)
　　DOI：10.1007/978-3-540-47648-1-2208.

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