山东大学生命科学学院导师介绍：刘巍峰

　　刘巍峰 教授
　　博士生导师
　　E-mail:weifliu@sdu.edu.cn
　　 
　　Cellulosic biomass bioconversion group
　　刘巍峰 Wei-feng LIU, PhD
　　Professor of Molecular Microbiology & Biochemistry
　　State Key Laboratory of Microbial Technology
　　Shandong University, Jinan 250100
　　Phone: +86-531-88564324 Fax: +86-531-88565610
　　E-mail:weifliu@sdu.edu.cn
　　 
　　EDUCATION & EXPERIENCE
　　2005-present Professor, School of Life Science, Shandong Univeristy
　　2002-2004 Research Fellow, Cancer Research UK, United Kingdom
　　1998-2001 Research Associate, Center for Cancer Research, Massachusetts Institute of Technology, USA.
　　1994-1997 Ph.D of Microbioogy, Shandong University
　　1991-1994 M.S of Microbiology, Shandong Univeristy
　　1987-1991 B.S of Microbiology, Shandong University
　　
　　RESEARCH INTERESTS
　　1) Biological conversion of cellulosic biomass
　　2) Mechanism of enzymatic catalysis
　　3) Signal transduction in cellular responses & gene transcription regulation
　　4) Biodiversity of lignocellulose-degrading microbes
　　 
　　承担课题
　　主持课题情况：
　　1. 结晶纤维素水解过程中外切葡聚糖酶持续催化机制的研究，国家自然科学基金，30770063
　　2. 泛素-蛋白酶体对转录激活因子GAL4调节机制的研究，国家自然科学基金30670027
　　3. 酶法裂解制备酵母胞壁免疫寡糖，863项目2006AA102342
　　4. 纤维素酶机制研究， 国家重点实验室重点课题
　　
　　SELECTED PUBLICATIONS
　　1) Zhang X, Chen G, Liu W.Reduction of xylose to xylitol catalyzed by Glucose-fructose oxidoreductase from Zymomonas mobilis.
　　FEMS Letters 2009 Feb 19.
　　2) Wang F, Li F, Chen G, Liu W. Isolation and characterization of novel cellulase genes from uncultured microorganisms in different environmental
　　niches. Microbiol Res 2009.
　　3) Yu S, Qin W, Zhuang G, Zhang X, Chen G, Liu W. Monitoring oxidative stress and DNA damage induced by heavy metals in yeast expressing a redox-sensitive green fluorescent protein. Curr Microbiol, 2009, 58(5):504-510.
　　4) Zhang X, Wang Y, Wang L, Chen G, Liu W, Gao P. Site-directed mutagenesis of manganese peroxidase from Phanerochaete chrysosporium in
　　an in vitro expression system. J Biotechnol 2009 139（2）：176-178.
　　5) Zhang X, Chen G, Liu W. Reduction of xylose to xylitol catalyzed by Glucose-fructose oxidoreductase from Zymomonas mobilis. FEMS Letters
　　2009 Feb 19
　　6) Li F, Wang S, Liu W, Chen G. Purification and characterization of poly(l-lactic acid)-degrading enzymes from Amycolatopsis orientalis ssp.
　　orientalis. FEMS Microbiol Lett. 2008, 282(1):52-8.
　　7）Ma A, Hu Q, Qu Y, Bai Z, Liu W, Zhuang G. The enzymatic hydrolysis rate of cellulose decreases with the irreversibly adsorbed
　　cellobiohydrolase I on cellulose. Enzymatic and Microbial Technology 2008，282（1）:52-58.
　　8) Yao Q, Sun T, Chen G, Liu W.Heterologous expression and site-directed mutagenesis of endoglucanaseCelA from Clostridium thermocellum. Biotech Lett 2007,29 (8):1243-7
　　9）Liu W, Svejstrup J. Promoter-independent in vitro assembly of an active transcription elongation complex. Progress in Biochimica & Biophysica 2006，33（10）：1000
　　10) Somesh B, Reid J, Liu W, Søgaard T, Erdjument-Bromage H, Tempst P, Svejstrup J. Multiple mechanisms confining RNA polymerase Ⅱ to polymerase undergoing transcriptional arrest. Cell 2005, 121:913-923

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