南京农业大学植物保护学院导师介绍：王源超

　　王源超 老师个人简历：
　　王源超，男，汉族，1968年11月生，山东荣成市人。1991年7月毕业于莱阳农学院农学系获得学士学位，1996年7月毕业于南京农业大学植保系获得博士学位，1996年10月至1999年3月在浙江大学生物技术研究所从事博士后研究，1999年4月起在南京农业大学工作至今。期间，先后在韩国、美国、加拿大和荷兰等实验室进行合作研究。现为南京农业大学教授，博士生导师，植病系主任，植物病理学国家重点学科负责人，国家大豆产业技术体系病虫害研究室主任。中国菌物学会理事，《植物病理学报》、《南京农业大学学报》、《植物保护》、《生物安全学报》和《大豆科学》编委。
　　长期从事卵菌病害成灾机理以及植物疫病控制的应用基础研究，对检疫性植物病原菌的快速检测技术、疫霉菌对寄主识别的分子机理、疫霉菌致病性的变异机制等进行了系统的研究。先后主持国家公益性行业科研专项、国家863计划项目、国家自然科学基金、国家973计划子课题和948项目等30余项。主要学术贡献：（1）澄清了大豆疫霉对寄主识别的分子机理，发现了大豆疫霉通过G蛋白信号系统调控对大豆根系分泌异黄酮的识别从而寻找寄主植物，该研究为筛选新的控制疫病药剂特供了重要的理论基础；（2）明确了大豆疫霉毒性变异机制，克隆两个新的大豆疫霉无毒基因、解释了中国大豆疫霉群体中主要无毒基因通过点突变、转座子插入和差异转录等方式进行着复杂的毒性变异、证明了疫霉菌的毒性蛋白可以相互协作控制植物对病原菌的先天免疫，从而促进病菌的侵染，该研究被选为植物学研究的顶级刊物Plant Cell的封面文章，研究结论对改良植物对卵菌病害的抗性有重要价值；（3）解释了植物对疫霉菌非寄主抗性的分子机理，鉴定了多种新的疫霉菌分泌类毒性蛋白，采用病毒诱导的基因沉默技术澄清了MPAK等多种细胞信号系统在非寄主植物对疫霉菌抗性中的作用；（4）发掘了一批可用于检疫性有害植物病原菌分子监测的分子靶标，并在此基础上开发了十余种病原菌快速检测技术，形成多项国家和行业标准，并得到广泛推广应用。
　　先后获得教育部自然科学奖和科技进步奖3项、在国内外刊物上发表研究论文100余篇，其中的包括Plant Cell、MPMI、Science等SCI期刊上论文50余篇，其中第一作者或联系作者27篇，总影响因子83，论文被SCI刊物引用260余次，获得国家发明专利5项，参编教材或著作3本。南京农业大学“133人才工程”学术带头人，南京农业大学优秀研究生导师和优秀教师，江苏省“青蓝工程”学术骨干，江苏省优秀科技工作者，江苏省高校优秀科技创新团队带头人，教育部新世纪优秀人才。
　　 
　　研究方向：
　　1. 大豆真菌病害的成灾规律与综合控制技术；
　　2. 植物疫病菌的功能基因组学；
　　3. 疫霉菌的分子遗传学、分子进化以及遗传多样性；
　　4. 重要检疫性植物病原真菌的快速分子检测、监测与病害诊断技术；
　　5. 外来入侵生物学。

　　研究课题：
　　1. 农业公益性行业科研专项，重要农作物疫病菌致病型的分布与病害控制（3-20）
　　2. 国家高技术研究发展863计划, 重要检疫性植物病原菌快速分子检测技术及试剂盒的研制（2006AA10Z433）
　　3. 国家大豆产业技术体系岗位科学家，大豆真菌病害
　　4. 国家 973计划子课题，外来大豆疫霉入侵的分子生态适应机制 （2009CB119200）

　　研究成果：
　　 1. Ye W, Wang X, Tao K, Lu Y, Dai T, Dong S, Dou D, Gijzen M, Wang Y. Digital gene expression profiling of the Phytophthora sojae transcriptome. 2011， Mol Plant Microbe Interact. Aug 17. [Epub ahead of print]
　　 2. Dong S, Yu D, Cui L, Qutob D, Tedman-Jones J, Kale SD, Tyler BM, Wang Y, Gijzen M.Sequence Variants of the Phytophthora sojae RXLR Effector Avr3a/5 Are Differentially Recognized by Rps3a and Rps5 in Soybean. PLoS One. 2011;6(7):e20172.
　　 3. Cui L, Yin W, Dong S, Wang Y.Analysis of polymorphism and transcription of the effector gene Avr1b in Phytophthora sojae isolates from China virulent to Rps1b. Mol Plant Pathol. 2011 Jul 4. doi: 10.1111
　　 4. Wang Q, Han C, Ferreira AO, Yu X, Ye W, Tripathy S, Kale SD, Gu B, Sheng Y, Sui Y, Wang X, Zhang Z, Cheng B, Dong S, Shan W, Zheng X, Dou D, Tyler BM, Wang Y. Transcriptional Programming and Functional Interactions within the Phytophthora sojae RXLR Effector Repertoire. Plant Cell. 2011, 23(6):2064-86. (cover story)
　　 5. Guo M, Chen Y, Du Y, Dong Y, Guo W, Zhai S, Zhang H, Dong S, Zhang Z, Wang Y, Wang P, Zheng X. The bZIP transcription factor MoAP1 mediates the oxidative stress response and is critical for pathogenicity of the rice blast fungus Magnaporthe oryzae. PLoS Pathog. 2011, 7(2):e1001302.
　　 6. Wang Y, Huang Q. Assays for effector-mediated suppression of programmed cell death in yeast. Methods Mol Biol. 2011;712:173-80.
　　 7. Shen D, Ye W, Dong S, Wang Y, Dou D.Characterization of intronic structures and alternative splicing in Phytophthora sojae by comparative analysis of expressed sequence tags and genomic sequences. Can J Microbiol. 2011: 57(2):84-90.
　　 8. Baxter L, Tripathy S, Ishaque N, Boot N, Cabral A, Kemen E, Thines M, Ah-Fong A, Anderson R, Badejoko W, Bittner-Eddy P, Boore JL, Chibucos MC, Coates M, Dehal P, Delehaunty K, Dong S, Downton P, Dumas B, Fabro G, Fronick C, Fuerstenberg SI, Fulton L, Gaulin E, Govers F, Hughes L, Humphray S, Jiang RH, Judelson H, Kamoun S, Kyung K, Meijer H, Minx P, Morris P, Nelson J, Phuntumart V, Qutob D, Rehmany A, Rougon-Cardoso A, Ryden P, Torto-Alalibo T, Studholme D, Wang Y, Win J, Wood J, Clifton SW, Rogers J, Van den Ackerveken G, Jones JD, McDowell JM, Beynon J, Tyler BM. Signatures of adaptation to obligate biotrophy in the Hyaloperonospora arabidopsidis genome. Science. 2010, 10;330:1549-51.
　　 9. Zhao W, Dong S, Ye W, Hua C, Meijer HJ, Dou X, Govers F, Wang Y.Genome-wide identification of Phytophthora sojae SNARE genes and functional characterization of the conserved SNARE PsYKT6. Fungal Genet Biol. 2011,48(3):241-51
　　 10. Liu T, Ye W, Ru Y, Yang X, Gu B, Tao K, Lu S, Dong S, Zheng X, Shan W, Wang Y, Dou D. Two host cytoplasmic effectors are required for pathogenesis of Phytophthora sojae by suppression of host defenses. Plant Physiol. 2011, 155(1):490-501.
　　 11. Guo M, Guo W, Chen Y, Dong S, Zhang X, Zhang H, Song W, Wang W, Wang Q, Lv R, Zhang Z, Wang Y, Zheng X.The basic leucine zipper transcription factor Moatf1 mediates oxidative stress responses and is necessary for full virulence of the rice blast fungus Magnaporthe oryzae. Mol Plant Microbe Interact. 2010, 23(8):1053-68
　　 12. Meng J, Wang YC, Rapid Detection of Phytophthora nicotianae in Infected Tobacco Tissues and Soil Samples Based on Its Ypt1 Gene，J Phytopathol，2010，158:1 –7.
　　 13. Yonglin Wang, Aining Li, Xiaoli Wang, Xin Zhang, Wei Zhao, Daolong Dou, Xiaobo Zheng, Yuanchao Wang* GPR11, a putative seven-transmembrane G protei1 n coupled receptor, controls zoospore development and virulence of Phytophthora sojae,Eukaryotic Cell, 2010, 9(2):242-250.
　　 13. Li AN., Wang, YL., Tao K, Huang Q., Dong SM, Zheng, XB., and Wang, YC*, PsSAK1, a stress-activated MAP kinase of Phytophthora sojae, is required for zoospore viability and infection of soybean, Molecular Plant-microbe Interaction, 2010 Aug;23(8):1022-31.
　　 14. Cui LK, Yin WX, Tang QH, Dong SM, Zheng XB, Wang YC*, Distribution, Pathotypes and Metalaxyl Sensitivity of Phytophthora sojae from Heilongjiang and Fujian Provinces in China, Plant disease, 2010, accepted
　　 15. Tang QH, Gao F, Li GY, Wang H, Zheng XB, Wang YC*, First Report of Root Rot Caused by Phytophthora sansomeana on Soybean in China, Plant disease, 2010, 94(3):378
　　 16. Yonglin Wang, Daolong Dou, Xiaoli Wang, Aining Li, Yuting Sheng, Chenlei Hua, Binyan Cheng, Xiaoren Chen, Xiaobo Zheng, Yuanchao Wang* The PsCZF1 gene encoding a C2H2 zinc finger protein is required for growth,development and pathogenesis in Phytophthora sojae, Microbial Pathogenesis 47 (2009) 78 –86
　　 17. Dong S, Qutob D, Tedman-Jones J, Kuflu K, Wang YC, Brett M.Tyler, Mark Gijzen. (2009) The Phytophthora sojae Avirulence Locus Avr3c Encodes a Multi-Copy RXLR Effector with Sequence Polymorphisms among Pathogen Strains. PLoS ONE 4(5): e5556.
　　 18. Qutob D, Tedman-Jones J, Dong S, Kuflu K, Pham H, Wang YC, et al. (2009) Copy Number Variation and Transcriptional Polymorphisms of Phytophthora sojae RXLR Effector Genes Avr1a and Avr3a. PLoS ONE 4(4): e5066.
　　 19. Zhang H, Fang Q, Zhang Z, Wang Y, Zheng X.The role of respiratory burst oxidase homologues in elicitor-induced stomatal closure and hypersensitive response in Nicotiana benthamiana, J Exp Bot. 2009;60(11):3109-22
　　 20. Chen X R, Cheng B P, Wang X L, Dong S M, Zheng XB, Wang YC. Green fluorescent protein (GFP) as a vital marker for studying the interaction of Phytophthora sojae and soybean.Chinese Sci Bull, 2009, 54: 2822―2829
　　 21. Chenlei Hua, Xiaobo Zheng and Yuanchao Wang*，2009，G protein α subunit may help zoospore to find the infection site and influence the expression of RGS protein，Communicative & Integrative Biology 2:2, 1-3
　　 22. Yunzhe Gan, Lisha Zhang, Zhengguang Zhang*, Suomeng Dong, Jun Li, Yuanchao Wang* and Xiaobo Zheng，2009，The LCB2 subunit of the sphingolip biosynthesis enzyme serine palmitoyltransferase can function as an attenuator of the hypersensitive response and Bax-induced cell death，New Phytologist 181: 127 –146
　　 23. SM Dong, ZG Zhang, XB Zheng, YC Wang*, 2008, Mammalian pro-apoptotic bax gene enhances tobacco resistance to pathogens, Plant Cell Reports.
　　 24. DL Dou, SD kale, XL Wang, YB Chen, QQ Wang, X Wang, J McDowell, YC Wang, B Tyler, 2008, Carboxy-terminal motifs common to many oomycete RXLR effectors are required for avirulence and suppression of BAX-mediated programmed cell death by Phytophthora sojae effector Avr1b, Plant Cell 20: 1118 –1133
　　 25. Hua, C., Wang, Y., Zheng, X., Dou, D., Zhang, Z., Govers, F. and Wang, Y. (2008) A Phytophthora sojae G protein α subunit is involved in chemotaxis to soybean isoflavones. Eukaryotic Cell, in press
　　 26. Xiao-Ren Chen1, Xin-Le Wang, Zheng-Guang Zhang, Yuan-Chao Wang*, Xiao-Bo Zheng, (2008)Differences in the induction of the oxidative burst in compatible and incompatible interactions of soybean and Phytophthora sojae, Physiology and Molecular Plant Pathology,(2008)73: 16 –24
　　 27. J. Meng and Y. C. Wang*, 2008, First report of Phytophthora tentaculata on Aucklandia lappa in China, Plant Disease, in press.
　　 28. J. Meng and Y. C. Wang*, 2008, Rapid Detection of Phytophthora nicotianae in Infected Tobacco Tissues and Soil Based on Ypt1 gene, J of Phytopathology, in press
　　 29. Y Wang, Z Ren, XB Zheng, YC Wang*, 2007, Detection of Phytophthora melonis in samples of soil, water and plant tissue with polymerase chain reaction, Can. J of Plant Pathologhy, 29,172-181.
　　 30. XR Chen, G Shen, YL Wang, XB Zheng, YC Wang*, Identification of Phytophthora sojaegenes upregulated during the early stage of soybean infection，FEMS Microbiol Lett 269 (2007) 280 –288
　　 31. QH Chen, YC Wang, XB Zheng*, Molecular mapping of two cultivar-specific avirulence genes in the rice blast fungus, Magnaporthe grisea, Molecular genetics and genomics, 2007.
　　 32. ZY Wang, YC Wang* XR Cheng, G Shen, XB zheng, Differential screening reveals genes differentially expressed in low- and high-virulence near-isogenic Phytophthora sojae lines, Fungal Genetics and Biology 2006,43:826-839
　　 33. YC Wang WL Zhang XB Zheng*, Rapid and sensitive detection of Phytophthora sojae in soil and infected soybeans using species specific PCR assays, Phytopathology, 2006,96:1315-1321 .
　　 34. ZY Wang, YC Wang* XB Zheng*, Genetic relationships among Chinese and American isolates of Phytophthora sojae assessed by RAPD markers, Chinese Science Bulletin 2006, 51:2095-2102.
　　 35. ZG Zhang, YC Wang* XB Zheng, Molecualr detection of Phytophthora capasici, Plant Pathology, 2006，55:770-775 .
　　 36. ZG Zhang, XB Zheng*, Wang YC, KO WH. Evaluation of the rearrangement of taxonomic position of Peronophythora litchii based on partial DNA sequences. BOTANICAL STUDIES.
　　 37. J Zeng, YC Wang* XB Zheng, A Phytophthora sojae gene of Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) induced in host infection and its anti-oxidative function in yeast, Chinese Science bulletni,2006,51:1316-1324 .
　　 38. QH Chen, YC Wang, XB Zheng*, Genetic analysis and molecular mapping of the avirulence gene PR1, a gene for host-species specificity in the blast fungus magnaporthe grisea, Genome, 2006, 49:1-9 .
　　 39. J Li, ZG Zhang, R Ji, YC Wang* XB Zheng*, Hydrogen Peroxide regulates elicitor PB90-induced cell death and defense in no-head Chinese cabbage, Physiology and Molecular Plant Pathology, 2006 67: 220 –230.
　　 40. QH Chen, YC Wang, XB Zheng*, Genetic Diversity of DNA Fingerprint Haplotypes and Pathotypes in Magnaporthe grisea populations in China, J of Phytopathology ,2006: 154, 361 –369.
　　 41. ZJ Yu, ZG Zhang, YC Wang*, XB Zheng*. Molecular Detection and Monitoring of Fusarium oxysporum f.sp. niveum and Mycosphaerella melonis in Infected Plant Tissues and Soil, FEMS microbiology letter，2005, 249: 39 –47.
　　 42. R Ji, ZG Zhang, YC Wang* XB Zheng, Phytophthora elicitor PB90 induce apoptosis in tobacco W38 suspension cell, Chinese Science bulletin, 2005,50(5):435-439.
　　 43. G Shen, YC Wang*,XB Zheng. Development of a PCR Assay for the Molecular Detection of Phytophthora boehmeriae in Infected Cotton, J. Phytopathology, 2005, 153: 291-296-6
　　 44. ZG Zhang, YC Wang* , XB Zheng* , The Role of SA in Hypersensitive Response and Systemic Acquired Resistance Induced by elicitor PB90 of Phytophthora boehmeriae，Physiology and Molecular Plant Pathology, 2004，65：31-38.
　　 45. YC Wang*, DW Hu, ZG Zhang, ZC Ma, XB Zheng, DB Li, Purification and immuno- cytolocalization of a novel P Phytophthora boehmeriae protein inducing hypersensitive reaction and systemic acquired resistance in tobacco and Chinese cabbage, Physiology and Molecular Plant Pathology, 2003(4): 223-232
　　
　　 国家科技发明专利：
　　75. 大豆疫霉的检测方法及其检测试剂盒，专利授权号：ZL03131531.3；
　　 76. 苜蓿黄萎病菌的分子检测试剂盒，专利授权号：ZL03131986.6；
　　 77. 一种防治农田环境恶性杂草水花生的生物除草剂，专利授权号：03146132.8；
　　 78. 一种新的诱导植物系统抗病性的激发子及其制备方法，专利受理号：03131531.3, 专利公开号：CN1470173

　　获得荣誉：
　　 1. 1999年度农业部科技进步二等奖，疫霉菌生殖生物学与抗药性研究；
　　 2. 2005年度教育部自然科学二等奖，疫霉菌多样性及其产生机制;
　　 3. 2007年度教育部科技进步一等奖，重要农作物病原检测试剂盒的研制与应用

　　社会兼职：
　　 1. 中国菌物学会理事；
　　 2. 江苏省植物病理学会理事
　　 3. 中国植物病理学会会员；
　　 4. 美国植物病理学会会员；
　　 5. 国际卵菌分子遗传委员会成员；
　　 6. 美国遗传学会会员；
　　 7. 《南京农业大学学报》编委；
　　 8. 《大豆科学》编委；
　　 9. 《植物保护》编委

　　联系方式：
　　 ************（Tel） Email：wangyc@njau.edu.cn