中科院广州生物研究院导师介绍:陈小平
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姓名: 陈小平 性别: 男
姓名: | 陈小平 | 性别: | 男 |
职务: | 职称: | 研究员 | |
学历: | 博士 | 通讯地址: | 广州萝岗区科学城开源大道190号 |
电话: | 邮政编码: | 510530 | |
传真: | 电子邮件: | chen_xiaoping@gibh.ac.cn |
简历:
1995-1998 中山医科大学病原生物学博士
1997-1997 美国加州大学(UCLA)医学院访问学者
1985-1988 中山医科大学传染病学硕士
1977-1980 广东医学院临床医学系
2004-现在中国科学院广州生物医药与健康研究院,研究员
2001-2004 广州市疾病预防控制中心艾滋病研究室主任,研究员
1998-2001 广州市疾病预防控制中心艾滋病研究室主任,副研究员
1994-1995 广州市疾病预防控制中心微生物科主任,副研究员
1988-1994 广州市疾病预防控制中心流行病科、病毒免疫科、微生物科助理研究员
1980-1985 广东医学院附属第一医院传染病教研室助教,住院医师
研究领域:
长期目标是研究和开发针对重大传染病和肿瘤防治的创新药物、疫苗和方法。本研究室在建立重大疾病的分子、细胞和动物模型的基础上,重点开展:
1.针对世界三大疾病(疟疾、癌症和艾滋病)的药物与疫苗研发。
2.疟疾与癌症、疟疾与艾滋病的相互作用及其机理研究。
3.癌症和艾滋病的基因和生物治疗研究。
代表论著:
Yao Y,Nashun B,Zhou T,Qin L,Qin L,…Zhao S,Xu J,Esteban M,Chen X.Generation of CD34+ Cells from CCR5-disrupted Human Embryonic and Induced Pluripotent Stem Cells.Human Gene Therapy.2012,23:238-242.
Li Q,Ruan Z,Zhang H,Peng N,Zhao S,Qin L,Chen X.Characterization of peripheral blood T lymphocyte subsets in Chinese rhesus macaques with repeated or long-term infection with Plasmodium cynomolgi.Parasitol Res.2012,110 (2):961-9.
Chen L,He Z,Qin L,Li Q,Shi X,Zhao S,Chen L,Zhong N,Chen X.Antitumor effect of malaria parasite infection in a murine Lewis lung cancer model through induction of innate and adaptive immunity.PLoS ONE.2011,6 (9):e24407.
Li X,He Z,Chen L,Li Y,Li Q,Zhao S,Tao Z,Hu W,Qin L,Chen X.Synergy of the antiretroviral protease inhibitor indinavir and chloroquine against malaria parasites in vitro and in vivo.Parasitol Res.2011;109:1519-1524.
Wang B,Li Q,Qin L,Zhao S,Wang J,Chen X.Transition of tumor-associated macrophages from MHC class IIhi to MHC class IIlow mediates tumor progression in mice.BMC Immunol.2011;12:43.
Li Y,Qin L,Peng N,Liu G,Zhao S,He Z,Chen X.The Antimalarial effect of human immunodeficiency virus protease inhibitors in rhesus macaques.Antimicrob Agents Chemother.2011,55:3039-42.
Jiang B,Qin L,Du Y,Peng N,Chen L,Chen Z,Chen X.Transgenic Plasmodium that expresses HIV-1 Gag elicits immunity and protects mice against vaccinia virus-gag and malarial parasites.Vaccine.2010,28:7915-7922
You J,He Z,Chen L,Deng G,Liu W,Qin L,Qiu F and Chen X.CH05-10,a novel indinavir analog,is a broad spectrum antitumor agent that induces cell cycle arrest,apoptosis,endoplasmic reticulum stress and autophagy.Cancer Science.2010;101:2644-51.
He Z,Chen L,You J,Qin L,Chen X.Antiretroviral protease inhibitors potentiate chloroquine antimalarial activity in malaria parasites by regulating intracellular glutathione metabolism.Exp Parasitol,2009;123:122-127.
Shi X,Qin L,Liu G,Zhao S,Peng N,Chen X.Dynamic balance of pSTAT1 and pSTAT3 in C57BL/6 mice infected with lethal or non-lethal Plasmodium yoelii.Cell Mol Immunol,2008;5:341-348.
He Z,Qin L,Chen L,Peng N,You J and Chen X.Synergy of human immunodeficiency virus protease inhibitors with chloroquine against Plasmodium falciparum in vitro and Plasmodium chabaudi in vivo.Antimicro Agents Chemother.2008;52:2653-56.
Zhang L,Yan K,Zhang Y,Huang R,Bian J,Zheng C,Sun H,Chen Z,Sun N,An R,Min F,Zhao W,Zhuo Y,You J,Song Y,Yu Z,Liu Z,Yang K,Gao H,Dai H,Zhang X,Wang J,Fu C,Pei G,Liu J,Zhang S,Goodfellow M,Jiang Y,Kuai J,Zhou G and Chen X.High-throughput synergy screening identifies beauvericin as a novel combination agent for the treatment of fungal infections.Proc Natl Acad Sci USA.2007;104:4606-4611.
Chen X,Cao Y.Consideration of highly active antiretroviral therapy in the prevention and treatment of severe acute respiratory syndrome.Clin Infect Dis2004;38:1030-1032.
Chen X,Li G,Tang X,et al.Lack of severe acute respiratory syndrome in 19 AIDS patients hospitalized together.J Acquir Immune Defic Syndr 2003;34:242-243.
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