中科院广州生物研究院导师介绍:胡文辉
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姓名: 胡文辉 性别: 男
姓名: | 胡文辉 | 性别: | 男 |
职务: | 职称: | 研究员 | |
学历: | 博士 | 通讯地址: | 广州萝岗区科学城开源大道190号B座三楼 |
电话: | 邮政编码: | 510530 | |
传真: | 电子邮件: | hu_wenhui@gibh.ac.cn |
简历:
2006.11 至今 研究员,中国科学院广州生物医药与健康研究院。
2002.12 – 2006.10 博士后,药物发现与化学生物学中心,美国西北大学医学院。
1999.09 – 2002.07 博士,药物化学,中国医学科学院和北京协和医科大学药物研究所
胡文辉博士,现任中科院广州生物医药与健康研究院研究员,药物化学专业博士生导师。2002年毕业于中国医学科学院药物研究所,师从郭宗儒教授,开展COX-2抑制剂的研究,参与了我国一类新药艾瑞西布(Imrecoxib)的部分合成工作。2002年12月-2006年11月在美国美国西北大学医学院从事博士后研究,期间发明了新型抗老年痴呆候选药物——Minozac,已进入临床研究。胡博士的相关的研究已申请了二十多项国际和国家发明专利,发表了SCI收录的国际学术论文二十多篇。通讯作者论文主要集中在Journal of MedicinalChemistry;Europen Journal of Medicinal Chemistry;Journal of Organic Chemistry; Antiviral Research等国际著名学术刊物上。
胡文辉实验室以药物分子设计与合成为核心,依靠与各个科研团队的合作,包括药理、药代、毒理评价等,确立候选药物,完成新药的发现过程;同时,依托国内制药百强企业,共同开发新药,形成完整的创新药物价值链。
研究领域:
1.新型抗糖尿病药物的研发。
2.炎症相关疾病的药物研发。
代表论著:
1.Anti-diabetic drug discovery
Hui Xie,Lili Zeng,Shaogao Zeng,Xin Lu,Guicheng Zhang,Xin Zhao,Na Cheng,Zhengchao Tu,Zhiyuan Li,Hongjiang Xu,Ling Yang,Xiquan Zhang,Min Huang,Junling zhao,Wenhui Hu*.Novel pyrrolopyrimidine analogues as potent dipeptidyl peptidase IV inhibitors based on pharmacokinetic property-driven optimization.Eur.J.Med.Chem.2012,52,205-212.
Jifeng Deng,Li Peng,Guicheng Zhang,Xiaobing Lan,Chufang Li,Fuxin Chen,Yayao Zhou,Zuoxian Lin,Ling Chen,Renke Dai,Hongjiang Xu,Ling Yang,Xiquan Zhang,Wenhui Hu*.The highly potent and selective dipeptidyl peptidase IV inhibitors bearing a thienopyrimidine scaffold effectively treat type 2 diabetes.Eur.J.Med.Chem.2011,46,71-76
2.Anti-influenza drug discovery
Xin Zhao,Yanling Jie,Matthew R.Rosenberg,Junting Wan,Shaogao Zeng,Wei Cui,Yiping Xiao,Zhiyuan Li,Zhengchao Tu,Marco G.Casarotto,Wenhui Hu*.Design and synthesis of pinanamine derivatives as anti-influenza A M2 ion channel inhibitors.Antiviral res.2012,96,91-99.
Xin Zhao,Chufang Li,Shaogao Zeng,Wenhui Hu*.Discovery of highly potent agents against influenza A virus.Eur.J.Med.Chem.2011,46,52-57.
Wenhui Hu*,Shaogao Zeng,Chufang Li,Yanling Jie,Zhiyuan Li and Ling Chen.Identification of Hits as Matrix-2 Inhibitors through the Focused Screening of a Small Primary Amine Library.J.Med.Chem.2010,53,3831-3834.
3.Anti-alzheimer's disease drug discovery
Identification of Aminopyridazine-Derived Antineuroinflammatory Agents Effective in an Alzheimer's Mouse Model.Wei Zhou,Guifa Zhong,Xiurong Rao,Hui Xie,Shaogao Zeng,Tianyan Chi,Libo Zou,Donghai Wu,and Wenhui Hu*.ACS Med.Chem.Lett.2012,ASAP.
Wenhui Hu,Hantamalala Ralay Ranaivo,Saktimayee M.Roy,Heather A.Behanna,Laura K.Wing,Lenka Munoz,Ling Guo,Linda J.Van Eldik and D.Martin Watterson.Development of a novel therapeutic suppressor of brain proinflammatory cytokine up-regulation that attenuates synaptic dysfunction and behavioral deficits.Bioorganic & Medicinal Chemistry Letters.2007,17(2):414-418.
Hantamalala Ralay Ranaivo,Jeffrey M.Craft,Wenhui Hu,Ling Guo,Laura K.Wing,Linda J.Van Eldik and D.Martin Watterson.Glia as a therapeutic target:attenuation of human Aß induced neuroinflammation and hippocampal deficits by oral administration of a selective inhibitor of glial activation.Journal of Neuroscience.2006,26(2):662-670.
Wenhui Hu,Hantamalala Ralay Ranaivo,Jeffrey M.Craft,Linda J.Van Eldik,and D.Martin Watterson.Validation of the neuroinflammation cycle as a drug discovery target using integrative chemical biology and lead compound development with an Alzheimer’s disease-related mouse model.Current Alzheimer Research.2005,2,197-205.
4.synthetic method:
Hong Li,Junling Zhao,Lili Zeng,Wenhui Hu*.Organocatalytic Asymmetric Domino Aza-MichaelMannich Reaction:Synthesis of Tetrahydroimidazopyrimidine Derivatives.J.Org.Chem.2011,76,8064–8069.
Tamás Sohajda,WenHui Hu,Li Li Zeng,Hong Li,Lajos Szente,Béla Noszál,Szabolcs Béni.Evaluation of the interaction between sitagliptin and cyclodextrin derivatives by capillary electrophoresis and nuclear magnetic resonance spectroscopy.Electrophoresis,2011,32,1–7.
Hong Li,Yingxue Liu,Qijun Liu,Wenhui Hu,Guochun Zhou.Synthesis of 2-amino-5-hydroxycaprolactam derivatives mediated by E-selective olefination and asymmetric oxidation of the enol ether.Synthesis.2010,23:4068-4074.
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