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中科院广州生物研究院导师介绍:郑辉


姓名: 郑辉 性别:
职务:   职称: 研究员
学历: 博士 通讯地址: 广州市开源大道190号
电话:   邮政编码: 510530
传真:   电子邮件: zheng_hui@gibh.ac.cn

  简历:
  2001-2005 清华大学生物科学与技术系 学士学位
  2005-2010美国明尼苏达大学药理系 博士学位
  2010-2010美国明尼苏达大学药理系 博士后
  2010-至今 中国科学院广州生物医药与健康研究院 研究员

  研究领域:
  1.神经干细胞与学习和记忆
  2.吗啡受体的信号通路和成瘾性研究
  3.胆固醇对于G蛋白偶联受体信号通路的影响

  代表论著:
  As Corresponding Author:
  11.Zheng,H.*,Zhang,Y.,Li,W.,Loh,H.H.& Law,P.Y.(2012)NeuroD modulates opioid agonist-selective regulation of adult neurogenesis and contextual memory extinction Neuropsychopharmacol Accepted.
  10.Zheng,H.*,Zou,H.,Liu,X.,Chu,J.,Zhou,Y.,et al.(2012)Cholesterol level influences opioid signaling in cell models and analgesia in mice and humans J Lipid Res 53,1153-62.
  09.Zheng,H.*,Pearsall,E.A.,Hurst,D.P.,Zhang,Y.,Chu,J.,et al.(2012)Palmitoylation and membrane cholesterol stabilize mu-opioid receptor homodimerization and G protein coupling BMC Cell Biol 13,6.
  08.Zheng,H.*,Law,P.Y.& Loh,H.H.(2012)Non-Coding RNAs Regulating Morphine Function:With Emphasis on the In vivo and In vitro Functions of miR-190 Front Genet 3,113.
  07.Zheng,H.*,Chu,J.,Zhang,Y.,Loh,H.H.& Law,P.Y.(2011)Modulating micro-opioid receptor phosphorylation switches agonist-dependent signaling as reflected in PKCepsilon activation and dendritic spine stability J Biol Chem 286,12724-33.
  06.Zheng,H.*,Chu,J.,Zeng,Y.,Loh,H.H.& Law,P.Y.(2010)Yin Yang 1 phosphorylation contributes to the differential effects of mu-opioid receptor agonists on microRNA-190 expression J Biol Chem 285,21994-2002.
  05.Zheng,H.*,Loh,H.H.& Law,P.Y.(2010)Agonist-selective signaling of G protein-coupled receptor:Mechanisms and implications IUBMB Life 62,112-119.
  04.Zheng,H.*,Zeng,Y.,Chu,J.,Kam,A.Y.,Loh,H.H.,et al.(2010)Modulations of NeuroD activity contribute to the differential effects of morphine and fentanyl on dendritic spine stability J Neurosci 30,8102-10.
  03.Zheng,H.*,Zeng,Y.,Zhang,X.,Chu,J.,Loh,H.H.,et al.(2010){micro}-Opioid Receptor Agonists Differentially Regulate the Expression of miR-190 and NeuroD Mol Pharmacol 77,102-109.
  02.Zheng,H.*,Chu,J.,Qiu,Y.,Loh,H.H.& Law,P.Y.(2008)Agonist-selective signaling is determined by the receptor location within the membrane domains Proc Natl Acad Sci U S A 105,9421-6.
  01.Zheng,H.*,Loh,H.H.& Law,P.Y.(2008)(1)-Arrestin-Dependent {micro}-Opioid Receptor-Activated Extracellular Signal-Regulated Kinases (ERKs)Translocate to Nucleus in Contrast to G Protein-Dependent ERK Activation Mol Pharmacol 73,178-90.
  Others:
  04.Wu,Q.*,Hwang,C.K.,Zheng,H.,Wagley,Y.,Lin,H.Y.et al.,(2012)MicroRNA 339 down-regulates mu-opioid receptor at the post-transcriptional level in response to opioid treatment FASEB J [Epub ahead of print]
  03.Chu,J.*,Zheng,H.,Loh,H.H.& Law,P.Y.(2008)Morphine-induced mu-opioid receptor rapid desensitization is independent of receptor phosphorylation and beta-arrestins Cell Signal 20,1616-24.
  02.Chu,J.*,Zheng,H.,Zhang,Y.,Loh,H.H.& Law,P.Y.(2010)Agonist-dependent mu-opioid receptor signaling can lead to heterologous desensitization Cell Signal 22,684-96.
  01.Pan,G.,Li,J.,Zhou,Y.,Zheng,H.& Pei,D*.(2006)A negative feedback loop of transcription factors that controls stem cell pluripotency and self-renewal Faseb J 20,1730-2.

  *如果发现导师信息存在错误或者偏差,欢迎随时与我们联系,以便进行更新完善。联系方式>>

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