中科院广州生物研究院导师介绍:郑辉
姓名: 郑辉 性别: 男
姓名: | 郑辉 | 性别: | 男 |
职务: | 职称: | 研究员 | |
学历: | 博士 | 通讯地址: | 广州市开源大道190号 |
电话: | 邮政编码: | 510530 | |
传真: | 电子邮件: | zheng_hui@gibh.ac.cn |
简历:
2001-2005 清华大学生物科学与技术系 学士学位
2005-2010美国明尼苏达大学药理系 博士学位
2010-2010美国明尼苏达大学药理系 博士后
2010-至今 中国科学院广州生物医药与健康研究院 研究员
研究领域:
1.神经干细胞与学习和记忆
2.吗啡受体的信号通路和成瘾性研究
3.胆固醇对于G蛋白偶联受体信号通路的影响
代表论著:
As Corresponding Author:
11.Zheng,H.*,Zhang,Y.,Li,W.,Loh,H.H.& Law,P.Y.(2012)NeuroD modulates opioid agonist-selective regulation of adult neurogenesis and contextual memory extinction Neuropsychopharmacol Accepted.
10.Zheng,H.*,Zou,H.,Liu,X.,Chu,J.,Zhou,Y.,et al.(2012)Cholesterol level influences opioid signaling in cell models and analgesia in mice and humans J Lipid Res 53,1153-62.
09.Zheng,H.*,Pearsall,E.A.,Hurst,D.P.,Zhang,Y.,Chu,J.,et al.(2012)Palmitoylation and membrane cholesterol stabilize mu-opioid receptor homodimerization and G protein coupling BMC Cell Biol 13,6.
08.Zheng,H.*,Law,P.Y.& Loh,H.H.(2012)Non-Coding RNAs Regulating Morphine Function:With Emphasis on the In vivo and In vitro Functions of miR-190 Front Genet 3,113.
07.Zheng,H.*,Chu,J.,Zhang,Y.,Loh,H.H.& Law,P.Y.(2011)Modulating micro-opioid receptor phosphorylation switches agonist-dependent signaling as reflected in PKCepsilon activation and dendritic spine stability J Biol Chem 286,12724-33.
06.Zheng,H.*,Chu,J.,Zeng,Y.,Loh,H.H.& Law,P.Y.(2010)Yin Yang 1 phosphorylation contributes to the differential effects of mu-opioid receptor agonists on microRNA-190 expression J Biol Chem 285,21994-2002.
05.Zheng,H.*,Loh,H.H.& Law,P.Y.(2010)Agonist-selective signaling of G protein-coupled receptor:Mechanisms and implications IUBMB Life 62,112-119.
04.Zheng,H.*,Zeng,Y.,Chu,J.,Kam,A.Y.,Loh,H.H.,et al.(2010)Modulations of NeuroD activity contribute to the differential effects of morphine and fentanyl on dendritic spine stability J Neurosci 30,8102-10.
03.Zheng,H.*,Zeng,Y.,Zhang,X.,Chu,J.,Loh,H.H.,et al.(2010){micro}-Opioid Receptor Agonists Differentially Regulate the Expression of miR-190 and NeuroD Mol Pharmacol 77,102-109.
02.Zheng,H.*,Chu,J.,Qiu,Y.,Loh,H.H.& Law,P.Y.(2008)Agonist-selective signaling is determined by the receptor location within the membrane domains Proc Natl Acad Sci U S A 105,9421-6.
01.Zheng,H.*,Loh,H.H.& Law,P.Y.(2008)(1)-Arrestin-Dependent {micro}-Opioid Receptor-Activated Extracellular Signal-Regulated Kinases (ERKs)Translocate to Nucleus in Contrast to G Protein-Dependent ERK Activation Mol Pharmacol 73,178-90.
Others:
04.Wu,Q.*,Hwang,C.K.,Zheng,H.,Wagley,Y.,Lin,H.Y.et al.,(2012)MicroRNA 339 down-regulates mu-opioid receptor at the post-transcriptional level in response to opioid treatment FASEB J [Epub ahead of print]
03.Chu,J.*,Zheng,H.,Loh,H.H.& Law,P.Y.(2008)Morphine-induced mu-opioid receptor rapid desensitization is independent of receptor phosphorylation and beta-arrestins Cell Signal 20,1616-24.
02.Chu,J.*,Zheng,H.,Zhang,Y.,Loh,H.H.& Law,P.Y.(2010)Agonist-dependent mu-opioid receptor signaling can lead to heterologous desensitization Cell Signal 22,684-96.
01.Pan,G.,Li,J.,Zhou,Y.,Zheng,H.& Pei,D*.(2006)A negative feedback loop of transcription factors that controls stem cell pluripotency and self-renewal Faseb J 20,1730-2.
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