中科院广州生物研究院导师介绍:许永
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姓名: 许永 性别: 男
姓名: | 许永 | 性别: | 男 |
职务: | 职称: | 研究员 | |
学历: | 博士 | 通讯地址: | 广州市开源大道190号 |
电话: | ************ | 邮政编码: | 510530 |
传真: | 电子邮件: | xu_yong@gibh.ac.cn |
简历:
2011.9 – 至今 研究员,中国科学院广州生物医药与健康研究院,中科院百人计划
2006.6 – 2011.8 博士后,结构生物学与药物发现中心,美国Van Andel研究所。
2004.8 – 2006.5 博士后,生命有机国家重点实验室,中国科学院上海有机化学研究所。
2001.9 – 2004.7 博士,药物发现与设计中心,中国科学院上海药物研究所。
1998.9 – 2001.7 硕士,辽宁师范大学化学系。
研究领域:
运用计算生物学、药物化学和结构生物学等方法研究生物大分子的结构与功能以及生物大分子与小分子间的相互作用,在此基础上针对重要靶标进行药物分子设计研究。
代表论著:
在国际期刊Science,Nature,Nature Structural & Molecular Biology,Cell Research,Science Signaling,Journal of Medicinal Chemistry等杂志上发表论文30余篇。
1.Cao,M.,Liu,X.,Zhang,Y.,Xue,X.,Zhou,X.E.,Melcher,K.,Gao,P.,Wang,F.,Zeng,L.,Zhao,Y.,Zhao,Y.,Deng,P.,Zhong,D.,Zhu,J.K.,Xu,H.E.& Xu,Y.* An ABA-mimicking ligand that reduces water loss and promotes drought resistance in plants.Cell Res,2013.
2.Zhao,L.H.,Zhou,X.E.,Wu,Z.S.,Yi,W.,Xu,Y.,Li,S.,Xu,T.H.,Liu,Y.,Chen,R.Z.,Kovach,A.,Kang,Y.,Hou,L.,He,Y.,Xie,C.,Song,W.,Zhong,D.,Xu,Y.,Wang,Y.,Li,J.,Zhang,C.,Melcher,K.& Xu,H.E.Crystal structures of two phytohormone signal-transducing alpha/beta hydrolases:karrikin-signaling KAI2 and strigolactone-signaling DWARF14.Cell Res,2013,23,436-439.
3.Gao,M.,Duan,L.,Luo,J.,Zhang,L.,Lu,X.,Zhang,Y.,Zhang,Z.,Tu,Z.,Xu,Y.,Ren,X.& Ding,K.Discovery and optimization of 3-(2-(Pyrazolo[1,5-a]pyrimidin-6-yl)ethynyl)benzamides as novel selective and orally bioavailable discoidin domain receptor 1(DDR1)inhibitors.J Med Chem,2013,56,3281-3295.
4.Soon,F.F.,Ng,L.M.,Zhou,X.E.,West,G.M.,Kovach,A.,Tan,M.H.,Suino-Powell,K.M.,He,Y.,Xu,Y.,Chalmers,M.J.,Brunzelle,J.S.,Zhang,H.,Yang,H.,Jiang,H.,Li,J.,Yong,E.L.,Cutler,S.,Zhu,J.K.,Griffin,P.R.,Melcher,K.& Xu,H.E.Molecular mimicry regulates ABA signaling by SnRK2 kinases and PP2C phosphatases.Science,2012,335,85-88.
5.Cheng,H.,Wan,J.,Lin,M.I.,Liu,Y.,Lu,X.,Liu,J.,Xu,Y.,Chen,J.,Tu,Z.,Cheng,Y.S.& Ding,K.Design,synthesis,and in vitro biological evaluation of 1H-1,2,3-triazole-4-carboxamide derivatives as new anti-influenza A agents targeting virus nucleoprotein.J Med Chem,2012,55,2144-2153.
6.Chang,S.,Zhang,L.,Xu,S.,Luo,J.,Lu,X.,Zhang,Z.,Xu,T.,Liu,Y.,Tu,Z.,Xu,Y.,Ren,X.,Geng,M.,Ding,J.,Pei,D.& Ding,K.Design,synthesis,and biological evaluation of novel conformationally constrained inhibitors targeting epidermal growth factor receptor threonine(7)(9)(0)--> methionine(7)(9)(0)mutant.J Med Chem,2012,55,2711-2723.
7.Martin,K.R.,Narang,P.,Xu,Y.,Kauffman,A.L.,Petit,J.,Xu,H.E.,Meurice,N.& MacKeigan,J.P.Identification of small molecule inhibitors of PTPsigma through an integrative virtual and biochemical approach.PLoS One,2012,7,e50217.
8.Malapaka,R.R.,Khoo,S.,Zhang,J.,Choi,J.H.,Zhou,X.E.,Xu,Y.,Gong,Y.,Li,J.,Yong,E.L.,Chalmers,M.J.,Chang,L.,Resau,J.H.,Griffin,P.R.,Chen,Y.E.& Xu,H.E.Identification and mechanism of 10-carbon fatty acid as modulating ligand of peroxisome proliferator-activated receptors.J Biol Chem,2012,287,183-195.
9.Fu,T.,Min,H.,Xu,Y.,Chen,J.& Li,G.Molecular Dynamic Simulation Insights into the Normal State and Restoration of p53 Function.Int J Mol Sci,2012,13.,9709–9740.
10.Blind,R.D.,Pineda-Torra,I.,Xu,Y.,Xu,H.E.& Garabedian,M.J.Ligand structural motifs can decouple glucocorticoid receptor transcriptional activation from target promoter occupancy.Biochem Biophys Res Commun,2012,420,839-844.
2012年前代表论文
11.Zhou,X.E.,Suino-Powell,K.M.,Xu,Y.,Chan,C.W.,Tanabe,O.,Kruse,S.W.,Reynolds,R.,Engel,J.D.& Xu,H.E.The orphan nuclear receptor TR4 is a vitamin A-activated nuclear receptor.J Biol Chem,2011,286,2877-2885.
12.Xie,Q.,Wondergem,R.,Shen,Y.,Cavey,G.,Ke,J.,Thompson,R.,Bradley,R.,Daugherty-Holtrop,J.,Xu,Y.,Chen,E.,Omar,H.,Rosen,N.,Wenkert,D.,Xu,H.E.& Vande Woude,G.F.Benzoquinone ansamycin 17AAG binds to mitochondrial voltage-dependent anion channel and inhibits cell invasion.Proc Natl Acad Sci U S A,2011,108,4105-4110.
13.Martin,K.R.,Xu,Y.,Looyenga,B.D.,Davis,R.J.,Wu,C.L.,Tremblay,M.L.,Xu,H.E.& MacKeigan,J.P.Identification of PTPsigma as an autophagic phosphatase.J Cell Sci,2011,124,812-819.
14.He,Y.,Xu,Y.(co-first author),Zhang,C.,Gao,X.,Dykema,K.J.,Martin,K.R.,Ke,J.,Hudson,E.A.,Khoo,S.K.,Resau,J.H.,Alberts,A.S.,MacKeigan,J.P.,Furge,K.A.& Xu,H.E.Identification of a lysosomal pathway that modulates glucocorticoid signaling and the inflammatory response.Sci Signal,2011,4,ra44.
15.Melcher,K.,Xu,Y.(co-first author),Ng,L.M.,Zhou,X.E.,Soon,F.F.,Chinnusamy,V.,Suino-Powell,K.M.,Kovach,A.,Tham,F.S.,Cutler,S.R.,Li,J.,Yong,E.L.,Zhu,J.K.& Xu,H.E.Identification and mechanism of ABA receptor antagonism.Nat Struct Mol Biol,2010,17,1102-1108.
16.Xu,Y.,Zhang,T.& Chen,M.Combining 3D-QSAR,docking,molecular dynamics and MM/PBSA methods to predict binding modes for nonsteroidal selective modulator to glucocorticoid receptor.Bioorg Med Chem Lett,2009,19,393-396.
17.Melcher,K.,Ng,L.M.,Zhou,X.E.,Soon,F.F.,Xu,Y.,Suino-Powell,K.M.,Park,S.Y.,Weiner,J.J.,Fujii,H.,Chinnusamy,V.,Kovach,A.,Li,J.,Wang,Y.,Li,J.,Peterson,F.C.,Jensen,D.R.,Yong,E.L.,Volkman,B.F.,Cutler,S.R.,Zhu,J.K.& Xu,H.E.A gate-latch-lock mechanism for hormone signalling by abscisic acid receptors.Nature,2009,462,602-608.
18.Suino-Powell,K.,Xu,Y.,Zhang,C.,Tao,Y.G.,Tolbert,W.D.,Simons,S.S.,Jr.& Xu,H.E.Doubling the size of the glucocorticoid receptor ligand binding pocket by deacylcortivazol.Mol Cell Biol,2008,28,1915-1923.
19.Xu,Y.& Wang,R.A computational analysis of the binding affinities of FKBP12 inhibitors using the MM-PB/SA method.Proteins,2006,64,1058-1068.
20.Xu,Y.,Liu,H.,Niu,C.,Luo,C.,Luo,X.,Shen,J.,Chen,K.& Jiang,H.Molecular docking and 3D QSAR studies on 1-amino-2-phenyl-4-(piperidin-1-yl)-butanes based on the structural modeling of human CCR5 receptor.Bioorg Med Chem,2004,12,6193-6208.
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