中科院广州生物研究院导师介绍:陈凌
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姓名: 陈凌 性别: 男
姓名: | 陈凌 | 性别: | 男 |
职务: | 创始院长(2004-2008) | 职称: | 研究员 |
学历: | 博士 | 通讯地址: | 广州市科学城开源大道190号 |
电话: | 邮政编码: | 510530 | |
传真: | 电子邮件: | chen_ling@gibh.ac.cn |
简历:
·1979-1985 上海第一医学院,医学学士
·1985年 考取CUSBEA项目赴美留学
·1985-1991 美国印第安那(Indiana University)大学医学院,生物化学与分子生物学博士生
·1992-1994 美国哈佛大学医学院分子药学系,Dana-Farber癌症研究所,博士后
·1994-1996 美国哈佛大学医学院(Harvard Medical School),讲师(Instructor)
·1997-2001 美国默克制药公司,默克实验室(Merck Research Laboratory),资深研究员(Senior Research Fellow),为曾进入大规模临床II期试验的MRKAd5艾滋病疫苗的第一发明人
·2001-2003 美国Lexicon Pharmaceuticals公司 生物制药部总监(Director of Biotherapeutics)
·2004-2008 中国科学院广州生物医药与健康研究院,创始院长,研究员
·2006 国家杰出青年科学基金获得者
·2006--中国科学技术大学生物医药技术系,创始系主任(2006-2008),客座教授
·2009-2011 英国葛兰素史克公司(GlaxoSmithKline),全球副总裁暨中国研发中心首席运营官
·2012 法国赛诺菲巴斯德公司(Sanofi Pasteur),全球副总裁
·2013--广州医学院/广州呼吸病研究所教授,呼吸疾病国家重点实验室常务副主任
·2013--中国科学院广州生物医药与健康研究院,特聘研究员
研究领域:
本研究室治学严谨,善于培养学生独立思考的能力。强调欲做事先做人,注重培养德才兼备的高水平复合型人才。目前已有9名博士生,8名硕士生毕业,学生毕业后或出国深造或已成为国内相关领域的研究骨干。本组正在进行的项目有:
·新型爱滋病疫苗研发。参与了国家传染病重大专项研究。近3年在国际病毒学及疫苗领域高端学术期刊J Virology,Vaccine发表了11篇论文。
·流感病毒及其疫苗研究。在国际上首先报告了构建可自主复制的携带绿色荧光蛋白(GFP)的重组流感病毒。
基因敲除小鼠研究基因新功能。发现了sPLA2可调控代谢及炎症及免疫反应。
代表论著:
·Sun C,Feng L,Zhang Y,Xiao L,Pan W,Li C,Zhang L,*Chen L,Circumventing anti-vector immunity using adenovirus-infected blood cells for repeated application of adenovirus vectored vaccines:proof-of-concept in rhesus macaques.J Virology,2012,86:11031-11042.
·Pan W,Dong Z,Meng W,Zheng W,Li T,Li C,Zhang B,*Chen L.Improvement of influenza vaccine strain A/Vietnam/1194/2004 (H5N1) growth with the neuraminidase packaging sequence from A/Puerto Rico/8/34.Hum Vaccine Immunother.2012,1;8(2)252-259.
·Zhang Y,Sun C,Feng L,Xiao L,*Chen L.Enhancement of Gag-specific but reduction of Env- and Pol-specific CD8+ T cell responses by SIV nonstructural proteins in mice.AIDS Research Human Retroviruses.2011,28(4):374-83.
·Sun C,Zhang Y,Zhang M,Hong Z,Ma X,*Chen L.Epidemiology of adenovirus type 5 neutralizing antibodies in healthy people and AIDS patients in Guangzhou southern China.Vaccine.2011,17;29:3837-41.
·Sun C,Zhang Y,Liu Y,Zhang M,*Chen L.Enhancement of immunogenicity of replication-defective adenovirus-based human immunodeficiency virus vaccines in rhesus monkeys.AIDS Research and Human Retroviruses.2011,27(6):681-686.
·Guan M,Qu L,Tan W,*Chen L,and Wong CW.Hepatocyte nuclear factor-4 alpha regulates liver triglyceride metabolism in part through secreted phospholipase A2 GXIIB.Hepatology,2011,53:458-466.
·Hu X,Meng W,Dong Z,Pan W,Sun C,*Chen L.Comparative immunogenicity of recombinant adenovirus-vectored vaccines expressing different forms of hemagglutinin (HA) proteins from the H5 serotype of influenza A viruses in mice.Virus Res.2011,155:156-162.
·Li F,Feng F,Pan W,Dong Z,Li C,Sun C,*Chen L.Generation of replication-competent recombinant influenza A viruses carrying a reporter gene harbored in neuraminidase segment.J Virology,2010,84:12075-12081.
·Sun C,Zhang L,Zhang M,Liu Y,Zhong M,Ma X,*Chen L.Induction of balance and breadth in the immune response is beneficial for the control of SIVmac239 replication in rhesus monkeys.J Infect.2010;60:371-381.
·Xu W,Yi L,Feng Y,*Chen L,*Liu J.Structural insight into the activation mechanism of human pancreatic prophospholipase A2.J Biol Chem.2009;284:16659-16666.
·Shiver JW,Fu TM,Chen L,et al.Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity.Nature.2002,415:331-335.
·Chen L,Chen D,Block E,O'Donnell M,Kufe DW,Clinton,SK.Eradication of murine bladder carcinoma by intratumor injection of a bicistronic adenoviral vector carrying cDNAs for Interleukin-12 heterodimer and its inhibition by the IL-12 p40 subunit homodimer.Journal of Immunology,1997,159:351-359.
·Chen L,Yu L,Waxman DJ.Potentiation of cytochrome P450/cyclophosphamide-based cancer gene therapy by transfer of the P450 reductase gene.Cancer Research,1997,57:4830-4837.
·Chen L,Pulsipher M,Chen D,Elias A,Sieff C,Fine HA,Kufe DW.Adenovirus mediated transgene expression for detection and elimination of contaminating carcinoma cells in hematopoietic stem cell sources.Journal of Clinical Investigation,1996,98:2539-2548.
·Chen L,Waxman DJ,Chen D,Kufe DW.Sensitization of human breast cancer cells to cyclophosphamide and ifosphamide by transfer of a liver cytochrome P450 gene.Cancer Research,1996,56:1331-1340.
·Chen L,Chen D,Manome Y,Dong Y,Fine FA,Kufe DW.Breast cancer selective gene expression and therapy mediated by recombinant adenoviruses containing DF3/MUC1 promoter.Journal of Clinical Investigation,1995,96:2775-2782.
·Chen L,Waxman DJ.Intratumoral activation and enhanced chemotherapeutic effect of oxazaphosphorines following cytochrome P-450 gene transfer:development of a combined chemotherapy/cancer gene therapy strategy.Cancer Research,1995,55:581-589.
Chen L,Davis G J,Crabb D,Lumeng L.Intrasplenic transplantation of isolated periportal and perivenous hepatocytes as a long-term system for study of liver-specific gene expression.Hepatology 1994,19:989-998.
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