2021年考研上海工程技术大学孙智华教授课题组接收调剂研究生的通知

　　上海工程技术大学孙智华教授课题组拟招收2名硕士研究生（需要考数学）。欢迎大家报名。

　　主要从事有机小分子催化的不对称合成，过渡金属催化的方法学研究，生物活性分子化合物库的构建及其天然产物的全合成研究，药物合成工艺研究。目前主要研究新的氮杂卡宾，异硫脲类体系等有机小分子催化剂，并运用其催化不同类型的反应，以及含硼，硫，氟化合物的合成方法学研究，用于药物筛选。

　　该组已毕业28个研究生，毕业后主要分成二个去向：第一，国内外高校继续博士阶段受训；第二，国内企业从事药物合成研发。

　　调剂要求：必须报考工科专业，考试科目必须是英语一，数学二，必须达到国家一区分数线，英语过六级优先，认真踏实、责任心强。

　　研究兴趣：

　　1）有机合成：a) 天然活性产物的全合成。

　　b) 不对称合成。

　　c) 过渡金属催化的偶联的方法学。

　　d) 药物合成工艺。

　　2） 药物化学及设计：a)基于蛋白晶体结构的活性化合物的设计。

　　b)研究范围在肿瘤，抗病毒（乙肝，丙肝，艾滋病等），二型糖尿病。

　　最近发表的研究工作：

　　1）Xiaofang Lei, Yuanyuan Wang, Erkang Fan, and Zhihua Sun*, In Situ Activation of Disulfides for Multicomponent Reactions with Isocyanides and a Broad Range of Nucleophiles, Organic Letters, 2019, 21,?1484-1487.

　　2）Shengfeng Wu, Xiaofang Lei, Erkang Fan, and Zhihua Sun*, Thermolysis-Induced Two- or Multicomponent Tandem Reactions Involving Isocyanides and Sulfenic-Acid-Generating Sulfoxides: Access to Diverse Sulfur-Containing Functional Scaffolds, Organic Letters, 2018, 20,?522-525.

　　3）Fanghui Xu, Yuan Chen, Erkang Fan, and Zhihua Sun*, Synthesis of 3-Substituted Aryl [4, 5] isothiazoles Through an All Heteroatom Wittig-Equivalent Process, Organic Letters, 2016, 18,?2777-2779.

　　4）Haochen Xu and Zhihua Sun*, General Cycloaddition between a Trimethylsilyl-Capped Alkyne and an Azide Catalyzed by an N-Heterocyclic Carbene-Copper Complex and Pyridine-Biscarboxamide, Advanced Synthesis & Catalysis. 2016, 358, 1736-1740.

　　5）Tao Liu, Ling-yan Chen and Zhihua Sun*, Asymmetric Reduction of tert-Butanesulfinyl Ketimines by N-Heterocyclic Carbene Boranes, The Journal of Organic Chemistry, 2015, 80, 11441-11446.

　　6）Juhong Wei and Zhihua Sun*, tert-Butyl Sulfoxide as a Starting Point for the Synthesis of Sulfinyl Containing Compounds, Organic Letters, 2015, 17, 5396-5399. Liliang Huang, Chengxiang He and Zhihua Sun*, Application of Chan-Lam cross coupling for the synthesis of N-heterocyclic carbene precursors bearing strong electron donating or withdrawing groups; Scientific Reports. 2015, 5, 12432, DOI: 10.1038/srep12431.

　　7）Huihui Jia, Huangdi Feng, Zhihua Sun*, Multicomponent Domino Reactions of Hydrazinecarbodithioates: A Concise Access to 3-Substituted 5-Thiol-1, 3, 4-Thiadiazolines; Organic & Biomolecular Chemistry. 2015, 13, 8177-8181.

　　8）Huangdi Feng, Huihui Jia, and Zhihua Sun*, A Metal-Free Approach toward Saturated N-Propargyl Heterocycles via Annulation/Decarboxylative Coupling Sequence; Advanced Synthesis & Catalysis. 2015, 357, 2447-2452.

　　9）Huihui Jia, Huangdi Feng, Zhihua Sun*, Decarboxylativedipropargylation of primary amines with propiolic acids and formaldehyde via metal-free coupling, Tetrahedron. 2015, 71, 2724-2728.

　　10）Yuyu Xia, Ling-yan Chen, Shang Lv, Zhihua Sun*, and Bing Wang*, Microwave-Assisted or Cu-NHC-Catalyzed Cycloaddition of Azido Disubstituted Alkynes: Bifurcation of Reaction Pathways; The Journal of Organic Chemistry. 2014, 79, 9818-9825.

　　11）Huangdi Feng, Huihui Jia, and Zhihua Sun*, Mild and Catalyst-Free Petasis/Decarboxylative Domino Reaction: Chemoselective Synthesis of NBenzyl Propargylamines; The Journal of Organic Chemistry. 2014, 79, 11812?11818.

　　12）Liliang Huang, Yong Cao, Manping Zhao, Zhongfeng Tang and Zhihua Sun*, Asymmetric borylation of α, β-unsaturated esters catalyzed by novel ring expanded N-heterocyclic carbenes based on chiral 3, 4-dihydroquinazolinium compounds; Organic & Biomolecular Chemistry. 2014, 12, 6554-6356.

　　13）Feng Gao, Huangdi Feng and Zhihua Sun*, Pd-NHC-Catalyzed Synthesis of diaryl ketones; Tetrahedron Letters. 2014, 55, 6451-6454.

　　14）Kun Wen, Han Wang, Jinbo Chen, He Zhang, Xiaodan Cui, Chao Wei, Erkang Fan and Zhihua Sun*, Improving Carbene-Copper Catalyzed Asymmetric Synthesis of alpha-Aminoboronic Esters Using Benzimidazole-Based Precursors; The Journal of Organic Chemistry. 2013, 78, 3405-3409.

　　15）Le Wang, Yan Wang, Yue Zheng, Pinaki S. Bhadury and Zhihua Sun*, Regioselective formylation of 1, 3-disubstituted benzene through in situ Lithiation; Tetrahedron Letters. 2013, 54, 6053-6056.

　　16）Han Wang, Yuyu Xia, Shang Lv, Jingli Xu and Zhihua Sun*, Facial and Practical Synthesis of Benzimidazole-Based N-Heterocyclic Carbenes; Tetrahedron Letters. 2013, 54, 2124-2127.

　　17）Kun Wen, Jinbo Chen, Feng Gao, Pinaki S. Bhadury, Erkang Fan and Zhihua Sun*, Metal free catalytic hydroboration of multiple bonds in methanol using N-heterocyclic carbene under open atmosphere; Organic & Biomolecular Chemistry. 2013, 11, 6350-6356.

　　18）Zhihua Sun*, Han Wang, Kun Wen, Ya Li and Erkang Fan, Solvent free or low solvent large scale preparation of chloropyrimidine and analogs; The Journal of Organic Chemistry. 2011, 76, 4149-4153.