上海交通大学内科学专业导师介绍:陈智伟
►基本信息导师姓名:陈智伟性别:男专业名称:内科学专业代码:100201培养单位:附属胸科医院专业领域:呼吸系病导师类型:硕士生导师联系方式
►基本信息
导师姓名:陈智伟
性别:男
专业名称:内科学
专业代码:100201
培养单位:附属胸科医院
专业领域:呼吸系病
导师类型:硕士生导师
联系方式:drchenzhiwei@163.com
邮箱地址:drchenzhiwei@163.com
邮编:200030
►研究方向
主要专长为肺癌的多学科诊治,特别是肺癌的化疗、靶向治疗、微创介入治疗、中西医结合
►社会任职
上海市医学会肿瘤靶分子分会青年委员兼秘书
上海市医学会肿瘤学会青年学组(SYOS)秘书
上海市医学会肿瘤学会青年委员
中国老年学会老年肿瘤专业委员会(CGOS)执行委员会委员
CommitteeMemberOfTheAsianSocietyofCryosurgery
中国抗癌协会临床肿瘤学协作专业委员会(CSCO)青年专家委员会委员
中国抗癌协会临床肿瘤学协作专业委员会(CSCO)执行委员会委员
►科研项目
抗肿瘤血管药物联合顺铂对人肺腺癌耐顺铂细胞株A549/DDP的作用
国家中医药管理局国家中医临床研究基地业务建设科研专项课题--非小细胞肺癌中西医结合治疗的研究
中医引导项目--晚期非小细胞肺癌个体化中西医结合治疗
分子诊断技术在肺癌个体化治疗中的应用研究卫生部医药卫生科技发展研究中心
中药现代化专项--中医综合治疗方案防治肺癌的临床研究
上海市自然科学基金--肺癌EGFR靶向治疗的基础研究
►学术论文
1.Ye XY, Luo QQ, Xu YH, Tang NW, Niu XM, Li ZM, Shen SP, Lu S, Zhiwei Chen (通讯作者) 17-AAG suppresses growth and invasion of lung adenocarcinoma cells via regulation of the LATS1/YAP pathway. J Cell Mol Med. 2015 19(3):651-63
2.Zhiwei Chen, Ye X, Tang N, Shen S, Li Z, Niu X, Lu S, Xu L The histone acetylranseferase hMOF acetylates Nrf2 and regulates anti-drug responses in human non-small cell lung cancer. Br J Pharmacol. 2014 171(13):3196-211
3.Zhiwei Chen, Liu B, Tang NW, Xu YH, Ye XY, Li ZM, Niu XM, Shen SP, Lu S, Xu L FBXL5-mediated degradation of single-stranded DNA-binding protein hSSB1 controls DNA damage response. Nucleic Acids Res. 2014 42(18):11560-9
4.Li Z, Xu L, Tang N, Xu Y, Ye X, Shen S, Niu X, Lu S, Zhiwei Chen (通讯作者) The polycomb group protein EZH2 inhibits lung cancer cell growth by repressing the transcription factor Nrf2. FEBS Lett. 2014 588(17):3000-7
5.Zhiwei Chen, Ling Xu, Xiangyun Ye,Shengping Shen,Ziming Li,Xiaomin Niu,Shun Lu Polymorphisms of microRNA Sequences or Binding Sites and Lung Cancer: A Meta-Analysis and Systematic Review PLoS One 2013 8(4):e61008
6.Zhiwei Chen, Qingquan Luo, Hong Jian , Zhen Zhou, Baijun Cheng, Shun Lu, Meilin Liao Long-term results of a randomized controlled trial evaluating preoperative chemotherapy in resectable non-small cell lung cancer. Onco Targets Ther. 2013 7;6:645-50.
7.Li Z, Xie QR, Zhiwei Chen (通讯作者), Lu S, Xia W Regulation of SIRT2 levels for human non-small cell lung cancer therapy. Lung Cancer. 2013 82(1):9-15
8.Xiangyun Ye,Xiaomin Niu,Ziming Li,Yongfeng Yu,Shun Lu, Zhiwei Chen (通讯作者) Adenovirus mediated knockdown of bone morphogenetic protein 2 inhibits human lung cancer growth and invasion in vitro and in vivo. Int J Immunopathol Pharmacol. 2012 25(4):967-76.
9.Zhiwei Chen, Xiaomin Niu, Ziming Li, Yongfeng Yu, Xiangyun Ye, Shun Lu, Zhen Chen Effect of ubiquitin carboxy-terminal hydrolase 37 on apoptotic in A549 cells Cell Biochem Funct 2011 29(2):142-8
10.Zhiwei Chen, Ziming Li, Xiaomin Niu, Xiangyun Ye, Yongfeng Yu, Shun Lu, Zhen Chen The effect of CYP1A1 polymorphisms on the risk of lung cancer a global meta-analysis based on 71 case–control studies. Mutagenesis 2011 26(3):437-46
11.Zhengbo Song, Yongfeng Yu, Zhiwei Chen (共同第一作者), Shun Lu Third-line therapy for advanced non-small-cell lung cancer patients: feasible drugs for feasible patients. Med Oncol 2011 28 Suppl 1:S605-12
12.Xiaomin Niu,Zhiwei Chen (共同第一作者),Shengping Shen, Yun Liu, Daizhan Zhou, Jie Zhang, Ziming Li,Yongfeng Yu, Meilin Liao, Shun Lu, Lin He Association of the CHRNA3 locus with lung cancer risk and prognosis in Chinese Han population. J Thorac Oncol. 2010 5(5):658-66
13.Zhiwei Chen (共同第一作者), Yongfeng Yu, Da Fu, Ziming Li, Xiaoming Niu, Meilin Liao 1, Shun Lu Functional roles of PC-PLC and Cdc20 in the cell cycle, proliferation, and apoptosis. Cell Biochem Funct 2010 28(4):249-57
14.Yong-feng Yu, Zhi-wei Chen (共同第一作者), Zhen Zhou, Zheng-bo Song, Zi-ming Li, Hong Jian, Yi-fei Zhang, Shun Lu A cost-effectiveness analysis of docetaxel versus pemetrexed in second-line chemotherapy for stage IIIb or IV non-small cell lung cancer in China. Chemotherapy. 2010 56(6):472-477
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