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中科院上海药物研究所导师介绍:李援朝


  代表论著:
  BingZhou,HuanyuTang,HuijinFeng,YuanchaoLi*FirsttotalsynthesisoftripdiolideTetrahedron,2011,67,904-909
  BinZhang,HongliChen,HuijinFeng,YuanchaoLi??Stereoselectiveconstructionofasteroid5α,7α-oxymethylenederivativeanditsuseinthesynthesisofeplerenoneSteroids,2011,76,56-59
  BingZhou,XiaomeiLi,HuanyuTang,ZehongMiao,HuijinFengandYuanchaoLi*TotalsynthesisofnovelD-ring-modifiedtriptolideanalogues:tructure–cytotoxicactivityrelationshipstudiesontheD-ringoftriptolideOrganic&BiomolecularChemistry,2011,3176-3179
  Ya-XiYang,ZhengLi,Guo-RongChen,Yuan-ChaoLi*.Phase-TransferCatalysedEnantioselectiveEpoxidationofEstra-Δ5(10),9(11)-dieneUsingChiralAmmoniumSaltsDerivedfromCinchonaAlkaloids.LettersinOrganicChemistry,2010,7,163-167
  BingZhou,ZehongMiao,GangDeng,JianDing,YaxiYang,HuijinFeng,YuanchaoLi*SynthesisandbiologicalevaluationofnoveltriptolideanaloguesforanticanceractivityBioorganic&MedicinalChemistryLetters,2010,20,6217-6221
  Ya-XiYang,ZhengLi,Hui-JinFeng,Guo-RongChen,Yuan-ChaoLi,*Concisesynthesisoffive-memberedringcarbasugarsbasedonkeyring-closingmetathesisTetrahedronLetters,2010,51,3848-3851
  BingZhou,XiaomeiLi,HuijinFeng,YuanchaoLi,*Efficientsynthesisofthekeyintermediatetriptophenolidemethyletherforthesynthesisof(-)-triptolideTetrahedron,2010,66,5396-5401
  HongliChen,YuanchaoLi*,BiaoJiang*,HuijinFengIsolationandcharacterizationofrelatedimpuritiesin24-epibrassinolide;Tetrahedron,2009,65,2097-2101.
  ZhengLi,Zhao-LiZhou,Ze-HongMiao,Li-PingLin,Hui-JinFeng,Lin-JiangTong,JianDing,*andYuan-ChaoLi*Design,synthesis,andantitumorevaluationofnoveltriptolidederivativesaspotentialanticanceragents.J.Med.Chem.2009,52,5115-5123.
  Xiao-LongDu,Hong-LiChen,Hui-jinFengandYuan-ChaoLi*StereoselectiveTotalSynthesisofNatural(S)-BakuchiolandItsEnantiomerHelveticaChimicaActa,2008,91,371-378
  HongliChen,XiaolongDu,WeiTang,YuZhou,JianpingZuo,HuijinFeng,YuanchaoLi*Synthesisandstructure-immunosuppressiveactivityrelationshipsofbakuchiolanditsderivativesBioorganic&MedicinalChemistry,2008,16,2403-2411
  ChenH.L.;LiY.C.*Simpleandconvenientsynthesisof(±)BakuchiolLett.Org.Chem.,2008,5,467-469
  ZhengLi,GangDeng,Yuan-ChaoLi*ZnI2/Et3SiH:ANovelMildReductionSystemforDirectDeoxygenationofArylAldehydes,ketones,andα,β-UnsaturatedEnonesSynlett,2008,19,3053-3057
  GangDeng,ZhengLi,Shu-YingPeng,LiFangandYuan-ChaoLi*Anewroutetostereoselectiveconstructionof6β,7β-methyleneunitfromandrost-5-en-7-oneTetrahedron,2007,63,4630-4635
  FujiangGuo,HuijinFeng,YoufuWang,ChunZhang,YuanchaoLi*CharacterizationofrelatedimpuritiesinmegestrolacetateJournalofpharmaceuticalandbiomedicalanalysis,2006,41,418-1422
  QinGu,Yun-HongZheng,Yuan-ChaoLi*TwoNovelApproachestowardStereoselectiveIntroductionofβ-HydroxymethylGroupattheC-7Positionof5-AndrosteneSynthesis,2006,6,975-978
  ZhiJieXue,PingChen,ShuYingPengandYuanChaoLi*Synthesisanddeterminationofabsoluteconfigurationoftetracetate4a-carba-D-xylofuranosideTetrahedron,2006,62,199-204
  GuoFu-jiangandLiYuan-chao*NewSesquiterpenoidsfromLycianthesmarlipoensisHelveticaChimicaActa,2005,88,2364-2369
  ShaoDong、ZouChun-Yan、LuoCheng、TangXi-CanandLiYuan-Chao*Synthesisandevaluationoftacrine-E2020hybridsasacetylcholinesteraseinhibitorsforthetreatmentofAlzheimer'sdiseaseBioorganic&MedicinalChemistryLetters,2004,14(18),4639
  ZhengYun-HongandLiYuan-Chao*NovelStereoselectiveSynthesisof7β-Methyl-Substituted5-AndrosteneDerivativesJ.Org.Chem,2003,68,1603

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