中科院海洋研究所导师介绍:王玲玲
王玲玲,女,1973年2月出生。 理学博士,美国南加州大学、新泽西州立大学博士后,副研究员,硕士研究生导师
王玲玲,女,1973年2月出生。
理学博士,美国南加州大学、新泽西州立大学博士后,副研究员,硕士研究生导师。
联系方式:中国科学院海洋研究所实验海洋生物学重点实验室
山东省青岛市南海路7号,邮编:266071
电话:*************
E-mail:wanglingling@ms.qdio.ac.cn
研究工作及领域:主要从事海洋生物分子遗传学、分子免疫学以及海水养殖动物的病害防治等领域的研究分子免疫学以及海水养殖动物的病害防治等方面的研究。主持承担了973课题,国家自然科学基金(2项),山东省杰出青年基金,联合国UNDP项目,中国科学院知识创新工程项目等课题。
主要成果及奖励:在海洋无脊椎动物的免疫防御机制、抗病性状的遗传学基础等领域取得了创新性进展:1)在软体动物中发现了类似高等生物的补体样系统,证实扇贝中存在结构和功能相对完善的儿茶酚胺能系统和胆碱能系统,初步勾勒了海洋软体动物神经内分泌免疫调控特征。2)构建了栉孔扇贝和海湾扇贝遗传连锁图谱,筛选了参与扇贝免疫防御过程以及逆境适应的关键基因序列多态性位点,获得6个与扇贝抗病和抗逆性状相关的功能性SNP位点,相关研究成果对指导扇贝抗病/抗逆品种的分子设计育种和遗传选育具有重要指导作用。
近年来共发表SCI论文60余篇,其中以第一作者/通讯作者发表论文30余篇,参与编写专著2部。申请发明专利8项,获授权1项。相关研究成果分获省部级奖励5项,其中2010年获国家海洋局创新成果二等奖(排名第一)。
主要代表性论文列表(+为通讯作者):
1.LeileiWang,LinglingWang+,JialongYang,HuanZhang,MengmengHuang,PengfeiKong,ZhiZhou,LishshengSong.Amulti-CRDC-typelectinwithbroadrecognitionspectrumandcellularadhesionfromArgopectenirradians.DevCompImmunol,2012,36(3):591–601.
2.XiaoweiShi,ZhiZhou,LinglingWang+,FengYue,MengqiangWang,ChuanyanYang,LinshengSong.TheImmunomodulationofAcetylcholinesteraseinZhikongScallopChlamysfarreri.PLoSOne.2012;7(1):e30828.
3.ZhiZhou,LinglingWang+,JialongYang,HuanZhang,PengfeiKong,MengqiangWang,LimeiQiu,LinshengSong.AdopaminebetahydroxylasefromChlamysfarrerianditsinducedmRNAexpressioninthehaemocytesafterLPSstimulation.FishShellfishImmunol,2011,30:154-162.
4.ZhiZhou,LinglingWang+,YangGao,MengqiangWang,HuanZhang,LeileiWang,LimeiQiu,LinshengSong.AmonoamineoxidasefromscallopChlamysfarreriservingasanimmunomodulatorinresponseagainstbacterialchallenge.DevCompImmunol,2011,35(7):799-807.
5.FengmeiLi,ShuyanHuang,LinglingWang+,JialongYang,HuanZhang,LimeiQiu,LingLi,LinshengSong.AmacrophagemigrationinhibitoryfactorlikegenefromscallopChlamysfarreri:Involvementinimmuneresponseandwoundhealing.DevCompImmunol,2011,35:62-71.
6.ZhiZhou,JialongYang,LinglingWang+,HuanZhang,YangGao,XiaoweiShi,LinshengSong.ADopaDecarboxylaseModulatingtheImmuneResponseofScallopChlamysfarreri.PLoSOne,2011,6(4):e18596.
7.ChuanyanYang,LeiZhang,LinglingWang+,HuanZhang,LimeiQiu,VinuSiva,LinshengSong.TheGln32LysPolymorphisminHSP22ofZhikongScallopChlamysfarreriisAssociatedwithHeatTolerance.PLoSOne,2011,6(12):e28564.
8.PengfeiKong,LinglingWang+,HuanZhang,XiaoyanSong,ZhiZhou,JialongYang,LimeiQiu,LeileiWang,LinshengSong.AnovelC-typelectinfrombayscallopArgopectenirradians(AiCTL-7)agglutinatingfungiwithmannosespecificity.FishShellfishImmunol,2011,30(3):836-44.
9.HuanZhang,XiaoyanSong,LinglingWang+,PengfeiKong,JialongYang,LinLiu,LimeiQiu,YingZhang,LihuaQiu,LinshengSong.AiCTL-6,anovelC-typelectinfrombayscallopArgopectenirradianswithalongC-typelectin-likedomain.FishShellfishImmunol.2011,30(1):17-26.
10.JialongYang,LinglingWang+,MengmengHuang,LeileiWang,YunchaoGai,LimeiQiu,HuanZhang,LishshengSong.Aninterleukin-2enhancerbindingfactor2homologinvolvedinimmuneresponsefromChinesemittencrabEriocheirsinensis.FishShellfishImmunol.2011,30(6):1303-9.
11.PengfeiKong,HuanZhang,LinglingWang+,ZhiZhou,JialongYang,YingZhang,LimeiQiu,LeileiWang,LinshengSong.AiC1qDC-1,anovelgC1q-domain-containingproteinfrombayscallopArgopectenirradianswithfungiagglutinatingactivity.DevCompImmunol.2010,34(8):837-846.
12.XuemeiYao,LinglingWang+,LinshengSong,HuanZhang,ChaohuaDong,YingZhang,LimeiQiu,YaohuaShi,JianminZhao,YongkunBi.ADicer-1genefromwhiteshrimpLitopenaeusvannamei:Expressionpatternintheprocessesofimmuneresponseandlarvaldevelopment.FishShellfishImmunol,2010,29:565-570.
13.LeiZhang,LinglingWang+,JianminZhao,LimeiQiu,LinshengSong,ChaohuaDong,FengmeiLi.Theresponsiveexpressionofheatshockprotein22geneinzhikongscallopChlamysfarreriagainstabacterialchallenge.AquacultureResearch.2010,41(2):257-266
14.LinglingWang,LinshengSong,DuojiaoNi,HuanZhang,WeiqingLiu.AlterationofmetallothioneinmRNAinbayscallopArgopectenirradiansundercadmiumexposureandbacteriachallenge.CompBiochemPhysiolCToxicolPharmacol,2009,149:50-57.
15. LinglingWang,LinshengSong,JianminZhao,LimeiQiu,HuanZhang,WeiXu,HongleiLi,ChenhuaLi,LongtaoWu,XimingGuo.Expressedsequencetagsfromthezhikongscallop(Chlamysfarreri):discoveryandannotationofhost-defensegenes.FishShellfishImmunol,2009,26:744-750.
16.LinglingWang,LinshengSong,ZhangHuan,QiangGaoandXimingGuo.Ageneticlinkagemapofbayscallop,Argopectenirradiansirradians(Lamarck1819).AquacultureResearch,2007,38(4):409-419.
17.LinglingWang,HuanZhang,LinshengSong,XimingGuo.LossofallelediversityinintroducedpopulationsofthehermaphroditicbayscallopArgopectenirradians.Aquaculture,Volume271,Issues1-4,3October2007,Pages252-259.
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