兰州大学研究生导师介绍：万东石

　　学习经历

　　1991.09-1995.07：甘肃农业大学园艺系，学士

　　2000.09-2003.07：兰州大学生命科学学院，硕士研究生

　　2006.09-2010.07：兰州大学生命科学学院，博士研究生

　　工作经历

　　1995.07-2000.08：兰州兰泰集团公司，助工；

　　2007.11-2008.11：Michigen State University，访问学者；

　　2003.07 至今：兰州大学生命科学学院，讲师、副教授、教授

　　教学及指导研究生情况

　　先后承担生物技术专业《基因工程》课堂教学，《基因工程实验》、《酶工程实验》教学工作；

　　承担生态学专业选修课《分子生态学》的教学工作；

　　先后研究生课程《高级生化实验II》，《分子生物学技术》等教学工作。

　　指导硕士研究生4人，协助指导硕士、博士研究生4人。

　　发表论文及专著

　　Nan Q, Qian D, Niu Y, He YX, Tong SF, Niu ZM, Ma JC, Yang Y, An LZ, Wan DS* and Xiang Y* (2017). Plant actin-depolymerizing factors possess opposing biochemical properties arising from key amino acid changes throughout evolution. The Plant Cell, 29: 1–14.

　　Luo WC, Zhang CH, Zhang J, Ma T, Guo W, Wan DS* (2017). Transcriptome analysis of four Poplars exposed to continuous salinity stress. Biochemical Systematics and Ecology, DOI:10.1016/j.bse.2017.01.001.

　　Ma JC ?, He XD ?, Bai XT ?, Niu ZM, Duan BB, Chen NN, Shao XM, Wan DS* (2016). Genome-wide survey reveals transcriptional differences underlying the contrasting trichome phenotypes of two sister desert poplars. Genes, doi:10.3390/genes7120111.

　　Hu QJ, Peng HC, Bi H, Lu ZQ, Wan DS, Wang Q and Mao KS (2016). Genetic homogenization of ITS loci across two morphologically distinct gentians in the overlaps between their distributions in the Qinghai-Tibet Plateau. Scientific Reports, DOI: 10.1038/srep34244.

　　Zhang X, Bai XT, Ma JC, Niu ZM, Xu JM, Liu X, Lei WL, Wan DS* (2016). Contrasting responses of two sister desert poplar species to rust infection and underlying changes in alternative pathway activity. Trees - Structure and Function, DOI: 10.1007/s00468-016-1435-0.

　　Zhang X, Wang K, Wang LZ, Yang YZ, Ni ZQ, Xie XY, Shao XM, Han J, Wan DS*, Qiu Q* (2016) Genome-wide patterns of copy number variation in the Chinese yak genome. BMC Genomics, DOI: 10.1186/s12864-016-2702-6.

　　Wan DS, Feng JJ, Jiang DC, Mao KS, Duan YW, Miehe G, Opgenoorth L (2016) The Quaternary evolutionary history, potential distribution dynamics and conservation implications for a Qinghai-Tibet Plateau endemic herbaceous perennial, Anisodus tanguticus (Solanaceae). Ecology and Evolution, doi: 10.1002/ece3.2019.

　　Zhang CH, Ma T, Luo WC, Xu JM, Liu JQ, Wan DS* (2015) Identification of 4CL genes in desert poplars and their changes in expression in response to salt stress. Genes doi:10.3390/genes6030901.

　　Ma YZ ?, Xu T ?, Wan DS ?, Ma T, Shi S, Liu JQ and Hu QJ (2015) The salinity tolerant poplar database (STPD): a comprehensive database for studying tree salt-tolerant adaption and poplar genomics. BMC Genomics doi:10.1186/s12864-015-1414-7(co-first authors).

　　Lu ZQ, Chen P. Bai XT, Xu JM, He XD, Niu ZM, Wan DS* (2015) Initial diversification, glacial survival, and continuous range expansion of Gentiana straminea (Gentianaceae) in the Qinghai–Tibet Plateau. Biochemical Systematics and Ecology 62, 219-228.

　　Wan DS, Sun YS, Zhang X, Bai XT, Wang J, Wang AL, Richard M (2014) Multiple ITS copies reveal extensive hybridization within Rheum (Polygonaceae), a genus that has undergone rapid radiation. PLoS ONE DOI: 10.1371/journal.pone.0089769.

　　Zhang J, Feng JJ, Lu J, Yang YZ, Zhang X, Wan DS, Liu JQ (2014) Transcriptome differences between two sister desert poplar species under salt stress. BMC Genomics 15:337 doi:10.1186/1471-2164-15-337.

　　Dai XG, Hu QJ, Cai QL, Feng K, Ye N, Tuskan G, Richard M, Chen YN, Wan ZB, Wang ZF, Luo WC, Wang K, Wan DS, Wang MX, Wang J, Liu JQ, Yin TM (2014) The willow genome and divergent evolution from poplar after the common genome duplication. Cell Research, doi:10.1038/cr.2014.83.

　　Lu ZQ, Tian B, Liu BB, Liu JQ, Wan DS* (2014) Genetic diversity and intraspecific genetic differentiation of Ostryopsis davidiana (Betulaceae) revealed by AFLP. http://www.paper.edu.cn.

　　Zhang J, Feng JJ, Lu J, Yang YZ, Zhang X, Wan DS* (2014) Transcriptome dynamics of a desert poplar (Populus pruinosa) in response to continuous salinity stress. Plant Cell Reports DOI: 10.1007/s00299-014-1638-z.

　　Ma T, Wang JY, Zhou GK, Yue Z, Hu QJ, Chen Y, Liu BB, Qiu Q, Wang Z, Zhang J, Wang K, Jiang D, Gou CY, Yu LL, Zhan DL, Zhou R, Luo WC, Ma H, Yang YZ, Pan SK, Fang DM, Luo YD, Wang X, Wang GN, Wang J, Wang Q, Lu X, Chen Z, Liu JC, Lu Y, Yin Y, Yang HM, Richard JA, Wu YX, Wan DS, Li J, Yin TM, Lascoux M, Stephen PD, Gerald AT, Wang J, Liu JQ (2013) Genomic insights into salt adaptation in a desert poplar. Nature Communications DOI: 10.1038/ncomms3797.

　　Sun YS, Wang AL, Wan DS, Liu JQ (2012) Rapid radiation of Rheum (Polygonaceae) and parallel evolution of morphological traits. Mol. Phylogenet. Evol. 63: 150-158.

　　Liu BB, Opgenoorth L, Miehe G, Zhang DY, Wan DS, Zhao CM, Jia DR, Liu JQ (2012) Molecular bases for parallel evolution of translucent bracts in an alpine “glasshouse” plant Rheum alexandrae (Polygonaceae). J Syst Evol 51: 134–141.

　　Wan DS*, Wang AL, Zhang X, Wang ZF, Li ZH (2011) Duplication and adaptive evolution of the CHS-like genes of the genus Rheum. Biochemical Systematics and Ecology, 39: 651-659.

　　Zhang DY, Liu BB, Zhao CM, Lu X, Wan DS, Ma F, Chen LT, Liu JQ (2010) Ecological functions and differentially expressed transcripts of translucent bracts in an alpine ‘glasshouse’ plant Rheum nobile (Polygonaceae). Planta, 231(6): 1505-1511.

　　Liu RR, Tian XM, Wang AL, Wan DS, Liu JQ (2010) Uniformity of karyotypes in Rheum (Polygonaceae), a species-rich genus in the Qinghai-Tibetan Plateau and adjacent regions. CARYOLOGIA 63(1): 82-90.

　　Chen FJ, Wang AL, Chen KM, Wan DS*, Liu JQ (2009) Genetic diversity and population structure of the endangered and medically important Rheum tanguticum (Polygonaceae) revealed by SSR Markers. Biochemical Systematics and Ecology, 37(5)613-621.

　　Li YQ, Wan DS, Huang SS, Leng FF, Yan L, Ni YQ, Li HY (2009) Type IV Pili of Acidithiobacillus ferrooxidans Are Necessary for Sliding, Twitching Motility, and Adherence. Curr Microbiol, DOI 10.1007/s00284-009-9494-8.

　　Wan DS, Wang AL, Wu GL, Zhao CM (2008) Isolation of polymorphic microsatellite markers from Przewalskia tangutica (Solanaceae). Conservstions Genetics, 995. 4, 995-997.

　　Wang AL, Yu QS, Liu BB, Wan DS* (2008) Isolation and characterization of microsatellite DNA primers for Sinadoxa corydalifolia (Adoxaceae). Conservstions Genetics, 4, 1075-1077.

　　Ni YQ, Wan DS He KY (2008) 16S rDNA and 16S–23S internal transcribed spacer sequence analyses reveal inter- and intraspecific Acidithiobacillus phylogeny. Microbiology-SGM, 154: 2397-2407(Co-first authors).

　　Ni YQ, He KY, Bao JT, Yang Y, Wan DS, Li HY (2008) Genomic and phenotypic heterogeneity of Acidithiobacillus spp. strains isolated from diverse habitats in China. FEMS Microbiology Ecology, 64 (2)2, 248 – 259.

　　Wang AL, Zhang Q, Wan DS, Yang YZ, Liu JQ (2008) Nine microsatellite DNA primers for Hippophae rhamnoides ssp. sinensis (Elaeagnaceae). Conservation genetics, 4, 969-972.

　　Yu QS, Zhang DY, Wan DS, Xu HY, Zhao CM (2008) Development of microsatellite DNA loci for Pugionium dolabratum (Brassicaceae), an endangered psammophyte. Conservation Genetics, 4: 1019-1022.

　　研究方向

　　植物比较功能基因组学

　　树木基因家族适应性进化的分子机制

　　项目成果

　　1．活性氧（H2O2）对胡杨叶虫害时抗氰交替途径的调节研究。国家自然科学基金（30972336） （2010-2012）；

　　2．应用荧光实时定量PCR技术对兰州地区马铃薯晚疫病检测预报。兰州市科技攻关项目（2009-1-29） （2009-2011）；

　　3．兰州大学教材出版基金，2010；

　　4．大黄属植物nrDNA ITS系统发育重建和物种分化研究。中央高校基本科研业务费专项资金资助，lzujbky-2011-30；

　　5．交替氧化酶基因家族不同成员在胡杨和灰杨物种分化过程中的选择压力比较和功能验证。国家自然科学基金（31270652） （2013-2016）；

　　6．胡杨抗逆HKT基因重复和功能分化研究。国家自然科学基金（31470620）（2015-2018）；

　　参加项目：

　　胡杨功能基因组研究与应用，“863”计划（2013AA102605-02）, （2013-2017）

　　荣誉、获奖

　　兰州大学教学成果一等奖（2007）

　　甘肃省教育厅教学成果奖（2008）

　　兰州大学隆基教学奖（2011）

　　甘肃省农牧渔业丰收奖（2012）