兰州大学研究生导师介绍：刘璞

　　学习经历

　　2002      武汉大学                                              学士     微生物

　　2008      University of Texas Health Science Center at Houston  博士     基因与发育

　　工作经历

　　2008-2010  University of Texas M.D.Anderson Cancer Center   博士后

　　2010至今   兰州大学生命科学学院                             副教授

　　教学及指导研究生情况

　　讲授《生物化学》等课程。

　　指导硕士研究生4名。

　　发表论文及专著

　　Liu P, Ji J, Wu Q, Ren J, Wu G, Yu Z, et al. Klebsiella pneumoniae sp. LZU10 degrades oil in food waste and enhances methane production from co-digestion of food waste and straw. International Biodeterioration & Biodegradation. 2018;126(Supplement C):28-36.

　　Wu G, Xiao X, Feng P, Xie F, Yu Z, Yuan W, Liu P, Li X. Gut remediation: a potential approach to reducing chromium accumulation using Lactobacillus plantarum TW1-1. Sci Rep. 2017;7(1):15000.

　　Liu X, Wu G, Zhang Y, Wu D, Li X, Liu P. Chromate Reductase YieF from Escherichia coli Enhances Hexavalent Chromium Resistance of Human HepG2 Cells. Int J Mol Sci. 2015;16(6):11892-902.

　　Zhang X, Wu W, Virgo N, Zou L, Liu P, Li X. Global transcriptome analysis of hexavalent chromium stress responses in Staphylococcus aureus LZ-01. Ecotoxicology. 2014;23(8):1534-45.

　　Wu G, Sun M, Liu P, Zhang X, Yu Z, Zheng Z, et al. Enterococcus faecalis strain LZ-11 isolated from Lanzhou reach of the Yellow River is able to resist and absorb cadmium. J Appl Microbiol. 2014;116(5):1172-80.

　　Wu D, Tao X, Wu G, Liu P. Prokaryotic Arsenate Reductase Enhances Arsenate Resistance in Mammalian Cells. Recent Pat Food Nutr Agric. 2014.

　　Thenappan A, Shukla V, Abdul Khalek FJ, Li Y, Shetty K, Liu P, et al. Loss of transforming growth factor beta adaptor protein beta-2 spectrin leads to delayed liver regeneration in mice. Hepatology. 2011;53(5):1641-50.

　　Liu P, Fu X, Johnson RL. Efficient in vivo doxycycline and cre recombinase-mediated inducible transgene activation in the murine trabecular meshwork. Invest Ophthalmol Vis Sci. 2011;52(2):969-74.

　　Lu L, Li Y, Kim SM, Bossuyt W, Liu P, Qiu Q, et al. Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver. Proc Natl Acad Sci U S A. 2010;107(4):1437-42.

　　Liu P, Johnson RL. Lmx1b is required for murine trabecular meshwork formation and for maintenance of corneal transparency. Dev Dyn. 2010;239(8):2161-71.

　　研究方向

　　1.重金属在哺乳动物体内的修复。

　　我国土壤重金属污染严重。目前土壤重金属的修复主要针对土壤本身，有物理、化学、植物、微生物等修复方法。生物修复法较安全，但实例研究还不多，且并未大面积推广。本课题组主要利用具有重金属修复能力的益生菌，如植物乳酸杆菌，片球菌等来提高哺乳动物抵御重金属的能力，并探讨其分子机理。

　　2.抗生素的体内分解。