兰州大学研究生导师介绍：何凯

　　学习经历

　　2008  美国俄克拉荷马大学植物与微生物系  博士

　　2003  四川大学生命科学院  硕士

　　2000  四川大学生命科学院  学士

　　工作经历

　　2013至今     兰州大学生命科学学院  教授

　　2009-2013  美国加州大学伯克利分校植物与微生物系  博士后

　　2005-2008  美国俄克拉荷马大学  教学助理

　　2003-2008  美国俄克拉荷马大学  研究助理

　　教学及指导研究生情况

　　本科生《细胞信号转导》教学

　　目前指导博士研究生4人，硕士研究生5人，已毕业硕士研究生4名

　　研究生主要研究方向：植物分子生物学、植物细胞信号转导、植物逆境适应等

　　欢迎有志于科学研究的同学加盟！

　　发表论文及专著

　　(*corresponding author; §contributed equally)

　　Gao Y., Wu Y., Du J., Zhan Y., Sun D., Zhao J., Zhang S., Li J. and He K.* (2017) Both light-induced SA accumulation and ETI mediators contribute to the cell death regulated by BAK1 and BKK1. Frontiers in Plant Science 25;8:622. doi: 10.3389/fpls.2017.00622.

　　Wei, Z., Yuan, T., Tarkowská, D., Kim, J., Nam, H.G., Novák, O., He, K., Gou, X. and Li, J. (2017) Brassinosteroid biosynthesis is modulated via a transcription factor cascade of COG1, PIF4 and PIF5. Plant Physiology 174(2):1260-1273

　　He, K.*, and Wu, Y. (2016) Receptor-Like Kinases and Regulation of Plant Innate Immunity. Enzymes, 40:105-142

　　Ou, Y., Lu, X., Zi, Q., Xun, Q., Zhang J., Wu, Y., Shi, H., Wei, Z., Zhao, B., Zhang, X., He, K., Gou, X., Li, C., Li, J. (2016) RGF1 INSENSITIVE 1 to 5, a group of LRR receptor-like kinases, are essential for the perception of root meristem growth factor 1 in Arabidopsis thaliana. Cell Research, 26(6), 686-698

　　Chen, L., Guan, L., Qian, P., Xu, F., Wu, Z., Wu, Y., He, K., Gou, X., Li, J., and Hou, S. (2016) NRPB3, the third largest subunit of RNA polymerase II, is essential for stomatal patterning and differentiation in Arabidopsis. Development, 2016 Mar 17. pii: dev.129098.

　　Du, J., Gao, Y., Zan, Y., Zhang, S., Wu, Y., Xiao, Y., Zou, B., He, K., Gou, X., Li, G., Lin, H., Li, J. (2016) Nucleocytoplasmic trafficking is essential for BAK1 and BKK1-mediated cell-death control. Plant Journal 85(4), 520-531.

　　Wu, Y., Xun, Q., Guo, Y., Zhang, J., Cheng, K., Shi, T., He, K., Hou, S., Gou, X., Li, J. (2016) Genome-wide expression pattern analyses of the Arabidopsis leucine-rich repeat receptor-like kinases. Molecular Plant 9(2), 289-300.

　　Wu, W., Wu Y., Gao, Y., Li, M., Yin, H., Lv, M., Zhao, J., Li, J., He, K.* (2015) Somatic embryogenesis receptor-like kinase 5 in the ecotype Landsberg erecta of Arabidopsis is a functional RD LRR-RLK in regulating brassinosteroid signaling and cell death control. Frontiers in Plant Science 6:852. doi: 10.3389/fpls.2015.00852

　　Zheng X.§, He K.§, Kleist T., Chen F., Luan S. (2015) Anion channel SLAH3 functions in nitrate-dependent alleviation of ammonium toxicity in Arabidopsis. Plant, Cell and Environment Mar;38(3):474-86

　　Hou C., Tian W., Kleist T., He K., Garcia V., Bai F., Hao Y., Luan S., Li L. (2014) DUF221 proteins are a family of osmosensitive calcium-permeable cation channels conserved across eukaryotes. Cell Research 2014 Feb 7. doi: 10.1038/cr.2014.14.

　　He K., Xu S., Li J. (2013) BAK1 directly regulates brassinosteroid perception and BRI1 activation. Journal of Integrative Plant Biology 55(12), 1264–1270. ( Cover article)

　　Lee SC., Lim CW., Lan W., He K., Luan S. (2013) ABA signaling in guard cells entails a dynamic protein-protein interaction relay from the PYL-RCAR family receptors to ion channels. Molecular Plant 6:528-38.

　　Gou, X.§, Yin, H.§, He, K.§, Du, J., Yi., J., Xu, S. Lin, H., Clouse, SD., Li, J. (2012) Genetic Evidence for an Indispensable Role of Somatic Embryogenesis Receptor Kinases in Brassinosteroid Signaling. PLoS Genetics 8(1): e1002452. doi:10.1371/journal.pgen.1002452.

　　Li J., Du J., He K., Gou X. (2011). Control of cell death by Receptor Kinases in Arabidopsis thaliana. In "Receptor-like Kinases in Plants: From Development to Defense (eds Birgit Kemmerling and Frans Tax)". Signaling and Communication in Plants (ed. Frantisek Baluska, Springer Publisher), Volume 13, pp79-91.

　　Yang, H., Gou, X., He, K., Xi, D., Du, J., Lin, H., Li, J. (2010) Arabidopsis BAK1 and BKK1 confer reduced susceptibility to Turnip Crinkle Virus. European Journal of Plant Pathology 127: 147-156.

　　Gou, X., He, K., Yang, H., Yuan, T., Lin, H., Clouse, S.D., Li, J. (2010) Genome-wide cloning and sequence analysis of leucine-rich repeat receptor-like protein kinase genes in Arabidopsis thaliana. BMC Genomics 11(1):19

　　He, K., Gou, X., Powell, R.A., Yang, H., Yuan, T, Guo, Z., and Li, J.(2008) Receptor-like protein kinases, BAK1 and BKK1, regulate a light-dependent cell-death control pathway. Plant Signaling & Behavior 3 (10), 813-815.

　　Wang, X., Kota, U., He, K., Blackburn, K., Li, J., Goshe, M.B., Huber, S.C., and Clouse, S.D.(2008) Sequential transphosphorylation of the BRI1/BAK1 receptor kinase pair impacts early events in brassinosteroid signaling. Developmental Cell 15, 220-235.

　　He, K., Gou, X., Yuan, T., Lin, H., Asami, T., Yoshida, S., Russell, S.D., Li, J. (2007) BAK1 and BKK1 regulate brassinosteroid-dependent growth and brassinosteroid-independent cell death pathways. Current Biology 17, 1109-1115.

　　Heese, A., Hann, D.R., Gimenez-ibanex, S., Jones, A., He, K., Li, J., Schroeder, J.I., Peck, S.C., Rathjen, J.P. (2007) The receptor-like kinase SERK3/BAK1 is a central regulator of innate immunity in plants. Proceedings of the National Academy of Sciences of the United States of America 104, 12217-12222.

　　Yuan, T., Fujioka, S., Takatsuto, S., Matsumoto, S., Gou, X., He, K., Russell, S.D., and Li, J.(2007) BEN1, a gene encoding a dihydroflavonol 4-reductase (DFR)-like protein, regulates the levels of brassinosteroids in Arabidopsis thaliana. The Plant Journal 51 (2), 220–233.

　　研究方向

　　N Stress

　　Nitrate sensing/signaling

　　N Foraging

　　项目成果

　　主持科研项目：

　　国家自然科学基金面上项目“拟南芥受体激酶BAK1 和BKK1 介导细胞死亡分子机理”（No.31471305）2015-2018，80万，主持，在研

　　中央高校基本科研业务费专项资金-自由探索-面上项目“BED1依赖 MAPK 途径调节植物花序发育”（lzujbky-2016-75）2016-2017，10万，主持，结题

　　中央高校基本科研业务费专项资金-科研创新团队培育项目“植物免疫与逆境响应的分子机制”（lzujbky-2015-ct01）2015-2016，50万，主持，结题

　　中央高校基本科研业务费专项资金-自由探索-重点项目“拟南芥蛋白激酶 SnRK1 的生物学功能研究”（lzujbky-2015-k17）2015-2016，14万，主持，结题

　　中央高校基本科研业务费专项资金-自由探索-面上项目“拟南芥阴离子通道蛋白介导氮平衡的分子机理”（lzujbky-2014-84）2014-2015，10万，主持，结题

　　参与科研项目：

　　国家作物转基因重大专项子课题，2016ZX08009-003-002，2016-2018，70万，参与，在研

　　国家自然科学基金植物激素作用的分子机理重大研究集成项目“ BAK1 调控油菜素内酯（BR）信号转导及器官发育的分子机制”（91317311）2014-2015，200万，参与，结题