广州医科大学研究生导师介绍：刘金保

　　近期论文
　　1.LiuJ,TangM,MestrilR,WangX.Aberrantproteinaggregationisessentialforamutantdesmintoimpairtheproteolyticfunctionoftheubiquitin-proteasomesystemincardiomyocytes.JMolCellCardiol2006;40(4):451-454
　　2.LiuJ,ChenQ,HuangW,HorakKM,ZhengH,MestrilR,WangX.Impairmentoftheubiquitin-proteasomesystemindesminopathymousehearts.FasebJ2006;20(2):362-364
　　3.ChenQ*,LiuJB*,HorakKM,ZhengH,KumarapeliAR,LiJ,LiF,GerdesAM,WawrousekEF,WangX.Intrasarcoplasmicamyloidosisimpairsproteolyticfunctionofproteasomesincardiomyocytesbycompromisingsubstrateuptake.CircRes2005;97(10):1018-1026
　　4.KumarapeliAR,HorakKM,GlasfordJW,LiJ,ChenQ,LiuJ,ZhengH,WangX.Anoveltransgenicmousemodelrevealsderegulationoftheubiquitin-proteasomesystemintheheartbydoxorubicin.FasebJ2005;19(14):2051-2053
　　5.DongX*,LiuJ*,ZhengH,GlasfordJW,HuangW,ChenQH,HardenNR,LiF,GerdesAM,WangX.Insitudynamicallymonitoringtheproteolyticfunctionoftheubiquitin-proteasomesysteminculturedcardiacmyocytes.AmJPhysiolHeartCircPhysiol2004;287(3):H1417-1425
　　6.YangH,ZhouP,HuangH,ChenD,MaN,CuiQC,ShenS,DongW,ZhangX,LianW,WangX,DouQP,LiuJ.Shikoninexertsantitumoractivityviaproteasomeinhibitionandcelldeathinductioninvitroandinvivo.IntJCancer2009;124(10):2450-2459
　　7.LiuJ,ZhengH,TangM,RyuYC,WangX.Atherapeuticdoseofdoxorubicinactivatesubiquitin-proteasomesystem-mediatedproteolysisbyactingonboththeubiquitinationapparatusandproteasome.AmJPhysiolHeartCircPhysiol2008;295(6):H2541-2550
　　8.YangH,LiuJ,DouQP.TargetingtumorproteasomewithtraditionalChinesemedicine.CurrDrugDiscovTechnol;7(1):46-53
　　9.HuangH,ZhangX,LiS,LiuN,LianW,McDowellE,ZhouP,ZhaoC,GuoH,ZhangC,YangC,WenG,DongX,LuL,MaN,DongW,DouQP,WangX,LiuJ.PhysiologicallevelsofATPnegativelyregulateproteasomefunction.CellRes;20(12):1372-1385
　　10.SuH,LiJ,MenonS,LiuJ,KumarapeliAR,WeiN,WangX.PerturbationofcullindeneddylationviaconditionalCsn8ablationimpairstheubiquitin-proteasomesystemandcausescardiomyocytenecrosisanddilatedcardiomyopathyinmice.CircRes;108(1):40-50