郑州大学生物工程系导师介绍:高艳锋
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高艳锋,副教授,硕士生导师。2001年毕业于兰州大学生命科学学院生物学基地班,获理学学士学位。2006年毕业
高艳锋,副教授,硕士生导师。2001年毕业于兰州大学生命科学学院生物学基地班,获理学学士学位。2006年毕业于兰州大学生命科学学院生物化学与分子生物学专业,获理学博士学位。2006年7月进入郑州大学生命科学学院,主要从事肿瘤免疫与多肽药物研究。河南省生物化学与分子生物学会秘书长,河南省杰出青年基金获得者,河南省优秀中青年骨干教师,郑州大学青年骨干教师。Cancer Letters, Bioorganic & Medicinal Chemistry Letters,Peptides,Protein & Peptide Letters和Journal of Food Biochemistry等SCI杂志的审稿人。Chinese Journal of Biology杂志编委。
承担课题:
[1] 国家自然科学基金(81172893)(主持):PD-1/PD-L1拮抗肽的筛选及其在肿瘤免疫治疗中的应用研究,起止年月:2012年~2015年
[2] 国家自然科学基金(30901362)(主持):乳腺癌PIWIL2、PLAC1抗原HLA-A2限制性CTL表位鉴定以及综合改造策略研究,起止年月:2010年~2012年
[3] 河南省杰出青年基金(主持)(134100510015):新型抗肿瘤多肽AS16的研究与开发,起止年月:2013年~2015年
[4] 河南省青年骨干教师资助计划(2010GGJS-016)(主持):靶向细胞周期的新型抗肿瘤多肽的设计与活性研究,起止年月:2010年~2012年
[5] 河南省基础与前沿技术项目(102300410077)(主持):基于MazEF复合物的新型抗菌肽的设计、合成与构效关系研究,起止年月:2010年~2012年
[6] 河南省医学科技攻关项目(201003008)(主持):基于CT抗原的乳腺癌HLA-A2限制性抗原肽表位的筛选,起止年月:2010年~2012年
[7] 河南省科技攻关项目(************)(主持):新型肿瘤抗原肽和广谱疫苗的研究,起止年月:2007年~2009年
[8] 河南省医学科技攻关项目(200703013)(主持):基于Cyclin/CDK复合物结构的抗肿瘤多肽的研究,起止年月:2007年~2009年
[9] “十二五”科技部“重大新药创制”重大专项(2012ZX09103301-023)(副组长):新型抗肿瘤多肽药物AS16的研制,起止年月:2012年~2015年
[10] 河南省重点科技攻关项目(112102310068)(第2):结核耐药相关抗原CTL表位的筛选与疫苗研制.起止年月:2011年~2013年
[11] 河南省杰出人才计划项目(************)(第2):结核病抗原肽表位的筛选和多价疫苗的研制.起止年月:2008年~2010年
发表的主要论文:
[1] Haili Wang, Xi Chen, Yanping Chen, Lei Sun, Guodong Li, Mingxia Zhai, Wenjie Zhai, Qiaozhen Kang, Yanfeng Gao*, Yuanming Qi*.Antitumor activity of novel chimeric peptides derived from cyclinD/CDK4 and the protein transduction domain 4.Amino Acids, 2013, 44(2):499-510.
[2] Ji Z, Shi X, Liu X, Shi Y, Zhou Q, Liu X, Li L, Ji X, Gao Y, Qi Y, Kang Q.The membrane-cytoskeletal protein 4.1N is involved in the process of cell adhesion, migration and invasion of breast cancer cells.Exp Ther Med.2012, 4(4):736-740.
[3] Yahong Wu, Yanfeng Gao*, Yujie He, Ranran Shi, Mingxia Zhai, Zongyin Wu, Meng Sun, Wenjie Zhai, Xi Chen, Yuanming Qi*.A novel cytotoxic T lymphocyte epitope analogue with enhanced activity derived from cyclooxygenase-2.Scand J Immunol.2012, 76(3):278-85.
[4] Chao Dai, Zhaoqing Xu*, Fei Huang, Zhengkun Yu*, Yan-Feng Gao*.Lewis Acid-Catalyzed, Copper(II)-Mediated Synthesis of Heteroaryl Thioethers under Base Free Conditions.Journal of Organic Chemistry.2012, 77(9):4414-9.
[5] Fei Chen, Mingxia Zhai, Yuhuang Zhu, Yuanming Qi, Wenjie Zhai, Yanfeng Gao*.In vitro and in vivo identification of a novel cytotoxic T lymphocyte epitope from Rv3425 of Mycobacterium tuberculosis.Microbiology and Immunology.2012, 56(8):548-53.
[6] Zongyin Wu, Yanfeng Gao*, Yahong Wu, Wei Liu, Meng Sun, Mingxia Zhai, Yuanming Qi, Yong Ye.Identification of a novel CD8+ T cell epitope derived from cancer-testis antigen MAGE-4 in oesophageal carcinoma.Scand J Immunol.2011, 74:561-567.
[7] Wei Liu, Mingxia Zhai, Zongyin Wu, Yuanming Qi, Yahong Wu, Chao Dai, Meng Sun, Lu Li, Yanfeng Gao* Identification of a novel HLA-A2-restricted cytotoxic T lymphocyte epitope from cancer-testis antigen PLAC1 in breast cancer.Amino Acids.2012, 42(6):2257-65.
[8] Yu-huang Zhu, Yan-feng Gao*, Fei Chen, Wei Liu, Ming-xia Zhai, Wen-jie Zhai, Yuan-ming Qi*, Yong Ye.Identification of novel T cell epitopes from efflux pumps of Mycobacterium tuberculosis.Immunology Letters.2011, 140(1-2):68-73.
[9] Jun-wei Zhao, Zhan-qiang Sun, Hong-guo Yang, Chong-zhen Zhang and Xiao-li Yu, Zi-lu Wen, Yan-feng Gao, Xiao-kui Guo, Yuan-ming Qi, Shu-lin Zhang.Cloning, expression and immunological evaluation of a short fragment from Rv3391 of Mycobacterium tuberculosis.Annals of Microbiology, 2011, 61(2):345-353.
[10] Hong Lv, Yan-feng Gao*, Ya-hong Wu, Ming-xia Zhai, Lu Li, Yu-huang Zhu, Wei Liu, Zong-yin Wu, Fei Chen, Yuan-ming Qi.Identification of a novel cytotoxic T lymphocyte epitope from CFP21, a secreted protein of Mycobacterium tuberculosis.Immunology Letters.2010, 133(2):94-8.
[11] Yanfeng Gao*, Kun Chen, Bin Zhang, Xiang Li, Lu Chen, Yuanjun Li, Xiangjiao Jia, Yongxing Lei, Zhongyi Yan, Liangliang Kong, Nan Wang, Wei Liu, Yuanming Qi.Antioxidant and free radical scavenging activity of the extracellular death factor in Escherichia coli.Peptides, 2010, 31(10):1821-1825.
[12] Dong-dong Wu, Yan-feng Gao, Li-xiang Chen*, Yuan-ming Qi*, Qiao-zhen Kang, Hai-li Wang, Lin-yu Zhu, Yong Ye, Ming-xia Zhai.Anti-tumor effects of a novel chimeric peptide on S180 and H22 xenografts bearing nude mice.Peptides.2010, 31(5):850-864.
[13] Yan-feng Gao, Zhan-qiang Sun, Feng Qi, Yuan-ming Qi*, Ming-xia Zhai, Hui-ping Lou, Li-xiang Chen, Yong-xin Li, Xian-yuan Wang.Identification of a new broad-spectrum CD8+ T cell epitope from over-expressed antigen COX-2 in esophageal carcinoma.Cancer Letters, 2009, 284(1):55-61.
[14] Hui-ping Lou, Yan-feng Gao*, Ming-xia Zhai, Yuan-ming Qi*, Li-xiang Chen, Hong Lv, Ji-bing Yu, Yong-xin Li.A novel peptide from α5 helix of Asterina pectinifera cyclin B conjugated to HIV-Tat49–57 with cytotoxic and apoptotic effects against human cancer cells.Bioorganic & Medicinal Chemistry Letters, 2008, 18(16):4633-4637.
[15] Yan-feng Gao, Ming-xia Zhai, Wei-xia Liu, Xin Liu, Ye Yuan, Yuan-ming Qi*, Rui Wang*.Structure-activity relationships of the dimeric analogues of endomorphin-2 with different lengths of spacers.Protein & Peptide Letters, 2008, 15(3):275-279.
[16] Chang-Feng Hu, Chuan-Jun Zhu, Yan-Feng Gao, Xuan Shao, Rui Wang, Yu-Xin Cui.Characteristic Fragmentation Behavior of the Analogs of endomorphin-2 with Phenylglycine in Position 3 or 4 by ESI-FT Tandem Mass Spectrometry.Chinese Chemical Letters.2008, 19(12):1479-1482.
[17] Yun Feng, Ying-wei Lu, Xin Lin, Yan-feng Gao, Qian-yu Zhao, Wei Li, Rui Wang*.Endomorphins and morphine limit anoxia-reoxygenation-induced brain mitochondrial dysfunction in the mouse.Life Sciences, 2008, 82(13-14):752-763.
[18] Xuan Shao, Yan-feng Gao, Chuan-jun Zhu, Xue-hui Liu, Jin-long Yao, Yu-xin Cui, Rui Wang*.Conformational analysis of endomorphin-2 analogs with phenylalanine mimics by NMR and molecular modeling.Bioorganic & Medicinal Chemistry, 2007, 15(10): 3539-3547.
[19] Li-xiang Chen, Yuan-ming Qi*, Rui Wang*, Xin Duan, Yan-feng Gao, Ding-jian Yang.Roles of nitric oxide synthase inhibitor on antinociceptive effects of μ-Opioid agonist in mice.Protein & Peptide Letters, 2006, 13(10): 993-997.
[20] Yan-feng Gao, Xin Liu, Wei-xia Liu, Yuan-ming Qi, Xue-feng Liu, Rui Wang*.Opioid receptor binding and antinociceptive activity of the analogues of endomorphin-2 and morphiceptin with phenylalanine mimics in the position 3 or 4.Bioorganic & Medicinal Chemistry Letters, 2006, 16(14):3688-3692.
[21] Yan-feng Gao, Xin Liu, Jie Wei, Bei-bei Zhu, Qiang Chen, Rui Wang*.Structure-activity relationship of the novel bivalent and C-terminal modified analogues of endomorphin-2.Bioorganic & Medicinal Chemistry Letters, 2005, 15(7):1847-1850.
[22] Jie Wei, Xuan Shao, Mao-zhen Gong, Bei-bei Zhu, Yu-xin Cui, Yan-feng Gao, Rui Wang*.Structure-activity relationships of novel endomorphin-2 analogues with N-O turns induced by α-aminoxy acids.Bioorganic & Medicinal Chemistry Letters, 2005, 15(12):2986-2989.
[23] Yi-feng Zhou, Rui Wang*, Zhao-qing Xu, Wen-jin Yan, Lei Liu, Yan-feng Gao, Chao-shan Da.Boc-L-proline as a new chiral ligand for enantioselective phenylacetylene addition to aromatic aldehydes.Tetrahedron: Asymmetry.2004, 15(4):589-591.
[24] Xin Lin, Ding-jian Yang, Wen-qing Cai, Qian-yu Zhao, Yan-feng Gao, Qiang Chen, Rui Wang*.Endomorphins, endogenous opioid peptides, provide antioxidant defense in the brain against free radical-induced damage.Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2003, 1639(3):195-202.
专利:
[1] PLAC1抗肿瘤CTL表位肽及其应用.专利授权号:ZL 201010205684.0
[2] PIWIL2抗肿瘤CTL表位肽及其应用.专利授权号:ZL201010276917.6
[3] 抗结核CTL表位肽.专利授权号:ZL 200910065403.3.
[4] MAGE-4抗肿瘤CTL表位肽及其应用.专利授权号:ZL201010212512.5
[5] 结核分枝杆菌抗原限制性表位肽.专利授权号:201010030225.3.
[6] 结核耐药相关外排蛋白来源抗结核CTL表位肽及其应用.专利授权号:201110138646.2
[7] MTA1来源的抗肿瘤CTL表位肽及其应用.专利授权号:201110138635.4
[8] PL2L60来源的CTL表位肽及其应用.专利授权号:201210001557.8
教材:
[1] 祁元明主编,高艳锋,张守涛副主编.生物化学实验原理与技术,化学工业出版社,2011.普通高等教育“十二五”规划教材。
[2] Understanding Tuberculosis IV: Analyzing the origin of Mycobacterium tuberculosis pathogenicity,InTech Press,2012,参编。
获奖情况:
[1] 第十一届中国国际多肽会“Yong Peptide Scientist Award”
[2] 河南省医学科技进步一等奖和河南省科技进步二等奖
[3] “沈琼食管癌研究奖励基金”优秀科研成果二等奖
[4] 河南省教学技能大赛二等奖
[5] 河南省自然科学优秀论文一等奖2项
[6] 河南省自然科学优秀论文二等奖4项
[7] 郑州大学“三育人”先进个人
[8] 河南省《生物化学》教学团队,主要完成人
[9] 《生物化学》校级精品课程,主要完成人
[10] 郑州大学“挑战杯”课外学术科技竞赛评审委员会委员
[11] 2007和2010年度郑州大学“挑战杯”活动特等奖和二等奖,指导教师
[12] 河南省优秀硕士学位论文,指导教师
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