浙江理工大学生命科学学院导师介绍：钱程

　　姓名：钱程　
　　性别：男　
　　职称：教授　
　　所在学院：生命科学学院　

　　个人简介：
　　钱程，教授、博士、博士生导师，常务副所长，浙江省特聘教授（钱江学者），浙江省“151人才工程”第一层次人才和高校优秀留学回国人员。曾是西班牙拉瓦那大学基因治疗研究室主任、教授。

　　主要研究方向
　　方向1：肿瘤干细胞及肿瘤发病机理
　　方向2：肿瘤生物基因治疗
　　方向3：基因表达的调控

　　科研项目
　　1．国家自然科学基金项目，靶向溶瘤腺病毒携带非编码小RNA和治疗基因协同治疗癌症的探索性研究，2009-2011，36万元, 项目负责人
　　2．国家863项目，新型溶瘤腺病毒载体靶向介导siRNA簇的研究， 90万元，2006-2009，负责人
　　3．国家973项目，靶向性、选择性基因表达调控元件及载体的研究，170万元，2004-2009 ，负责人
　　4．浙江省科技厅重点项目，新型腺病毒载体系统的开发以及在肿瘤基因治疗应用研究， 25万元，2006-2008 ，负责人

　　发表论文
　　发表SCI论文110余篇，近3年的代表性SCI论文：
　　1．Ma L, Liu J, Shen J, Liu L, Wu J, Li W, Luo J, Chen Q, Qian C (通讯作者). Expression of miR-122 mediated by adenoviral vector induces apoptosis and cell cycle arrest of cancer cells. Cancer Biol Ther. 2010 Apr 20;9(7). [Epub ahead of print]。
　　2．Yin Y, Lin F, Zhuang Q, Liu L, Qian C(通讯作者).. Generation of full-length functional antibody against preS2 of hepatitis B virus in hepatic cells in vitro from bicistrons mediated by gutless adenovirus. BioDrugs. 2009;23(6):391-7.
　　3．Hu J, Dong A, Fernandez-Ruiz V, Shan J, Kawa M, Martínez-Ansó E, Prieto J, Qian C (通讯作者). Blockade of Wnt signaling inhibits angiogenesis and tumor growth in hepatocellular carcinoma. Cancer Res. 2009 Sep 1;69(17):6951-9.
　　4．Luo J, Xia Q, Zhang R, Lv C, Zhang W, Wang Y, Cui Q, Liu L, Cai R, Qian C (通讯作者). Treatment of cancer with a novel dual-targeted conditionally replicative adenovirus armed with mda-7/IL-24 gene. Clin Cancer Res. 2008 Apr 15;14(8):2450-7
　　5．Cui Q, Jiang W, Wang Y, Lv C, Luo J, Zhang W, Lin F, Yin Y, Cai R, Wei P, Qian C (通讯作者). Transfer of suppressor of cytokine signaling 3 by an oncolytic adenovirus induces potential antitumor activities in hepatocellular carcinoma. Hepatology. 2008 Jan;47(1):105-12.
　　6．Pan Q, Liu B, Liu J, Cai R, Liu X, Qian C (通讯作者). Synergistic antitumor activity of XIAP-shRNA and TRAIL expressed by oncolytic adenoviruses in experimental HCC. Acta Oncol. 2008; 47(1):135 – 144..
　　7．Zhang W, Cai R, Luo R, Wang Y, Cui Q, Wei X, Zhang H, and Qian C (通讯作者). The oncolytic adenovirus targeting to TERT and RB pathway induced specific and potent anti-tumor efficacy in vitro and in vivo for hepatocellular carcinoma. Cancer Biology & Therapy 2007; 6(11): 1726 – 1732.
　　8．Pan QW, Zhong SY, Liu BS, Liu J, Cai R, Wang YG, Liu XY, Qian C (通讯作者). Enhanced sensitivity of hepatocellular carcinoma cells to chemotherapy with a Smac-armed oncolytic adenovirus. Acta Pharmacol Sin. 2007 Dec;28(12):1996-2004. Pan Q, Liu B, Liu J, Cai R, Wang Y, Qian C (通讯作者). Synergistic induction of tumor cell death by combining cisplatin with an oncolytic adenovirus carrying TRAIL. Mol Cell Biochem. 2007 Oct;304(1-2):315-23.
　　9．Guan M, Rodriguez-Madoz JR, Alzuguren P, Gomar C, Kramer MG, Kochanek S, Prieto J, Smerdou C, Qian C (通讯作者). Increased efficacy and safety in the treatment of experimental liver cancer with a novel adenovirus-alphavirus hybrid vector. Cancer Res. 2006 Feb 1;66(3):1620-9.
　　10．Schmitz V, Vilanueva H, Raskopf E, Hilbert T, Barajas M, Dzienisowicz C, Gorschluter M, Strehl J, Rabe C, Sauerbruch T, Prieto J, Caselmann WH, Qian C (通讯作者). Increased VEGF levels induced by anti-VEGF treatment are independent of tumor burden in colorectal carcinomas in mice. Gene Ther. 2006 Aug;13(16):1198-205.
　　11．Qian C (通讯作者), Liu XY, Prieto J. Therapy of cancer by cytokines mediated by gene therapy approach. Cell Res. 2006 Feb;16(2):182-8。

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