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浙江大学理学部导师介绍:雷鸣


  姓名:雷鸣
  性别:男
  所在学院:理学部
  单位:化学系
  职称:副教授(自然科学)

  工作研究领域:
  1.有机合成方法学和微流控合成研究
  2.分子影像探针和生物活性分子设计、合成
  3.beta-内酰胺类抗生素药物的合成研究 4. 药物多晶型及相关质量控制研究

  个人简介
  陕西西安人。1999年9月~2002年6月在浙江大学化学系有机化学和药物化学研究所博士;
  2002年7月~2004年5月浙江大学浙江海正药业(HISUN PHARMA.)博士后工作站博士后;
  2004年6月浙江大学化学系化学生物学和药物化学研究所副教授、硕士生导师;
  2009年6月被聘为浙江省医学分子影像重点实验室、浙江大学医学PET中心客座教授,兼任化学实验室主任。
  2012年3月~2013年3月澳大利亚联邦科学与工业研究组织(CSIRO)访问学者

  发表论文:
  2012
  Ming Lei*, Zujin Zhan, Wan Tian, Ping Lu One-pot, three-component synthesis of highly functionalized 1,3-oxazine derivatives from a,b-unsaturated imine, alkyne, and aldehyde Tetrahedron 2012, 68(16): 3361-3367.
  Ming Lei,* Wan Tian, Ruijun Hu, Wei Li, Hong Zhang Efficient Synthesis of 2-(trifluoromethyl)-2H-[1,3 oxazino[2,3-a]isoquinolines in a Continuous Flow Microreactor via Three-component Cascade Approach   Synthesis 2012 in press.
  2011
  Ming Lei*, Wang-Ze Song, Zu-Jin Zhan, Sun-Liang Cui and Fang-Rui Zhong Stereo- and Regioselective Three-Component Reaction in Water: Synthesis of Triazole Substituted Beta-  Lactams Via Click Reaction Lett. Org. Chem. 2011, 8, 163-169.
  Lei, Ming*, Zhan, Zujin, Chen, Xiaowei, Zhou, Yanshui, Zhang, Zhizhong Kinetics Study of the Synthesis of 1,3-Diamino-1,2,3-trioximinopropane from the Reaction of Malononitrileoxime with Hydroxylamine   ACTA CHIMICA SINICA 2011, 69(9): 1131-1134. Chen, Xiaowei, Zhan, Zujin, Li, Purui, Ge, Zhongxue, Lei, Ming* Kinetics Study of the Synthesis of Butyl(2-azidoethyl)nitramine from the Reaction of2-[butyl(nitro)  amino]ethyl nitrate from with Sodium azide ACTA CHIMICA SINICA 2011, 69(20): 2523-2526.
  2010
  Song W Z, Lei M, Shen Y, Wang Y G, et al. Copper-catalyzed four-component reaction of Baylis-Hillman adducts with alkynes, sulfonyl azides and alcohols Adv. Synth. Catal. 2010, 352(15): 2432-2436.
  Lei M*, Tian M, Zhang H, Click labeled peptides with fluorine-18 for PET imaging Curr. Med. Imaging Rev. 2010, 6(1): 33-41.
  2009
  Hong D, Lin X F, Zhu Y X, Lei M, Shen Y, Wang Y G, et al. Copper-catalyzed tandem nucleophilic ring opening/intramolecular oxidative amidation of N-tosylaziridines and hydrazones under aerobic conditions Org. Lett. 2009, 11(24): 5678-5681.
  Hu R J, Lei M*, Wei H G, Wang Y G, Ionic liquid-H2O resulting in a highly chemoselective oxidation of benzylic alcohols in the presence of aliphatic analogues catalyzed by immobilized TEMPO Chin. J. Chem.  2009, 27(3): 587-592.
  Lei M*, Wu D D, Wei H G, Wang Y G, Polymer-supported 4-aminoformoyl- diphenylammonium triflate (PS-AFDPAT): an effective and recyclable catalyst for the biginelli reaction Synthetic Comm. 2009, 39(3): 475-483.
  2008
  Hu R J, Lei M*, Xiong H S, Mu X, Wang Y G, Yin X F, Highly selective acylation of ferrocene using microfluidic chip reactor Tetrahedron Lett. 2008, 49(2): 387-389.
  2007
  Tao X L, Lei M*, Wang Y G, Ionic liquid supported synthesis of b-lactam library in ionic liquid batch Tetrahedron Lett. 2007, 48(29): 5143-5146.
  Tao X L, Lei M*, Wang Y G, Unexpected microwave reaction of 1,3-disubstituted imidazolium salts: a novel synthesis of 1,3-disubstituted imidazole-2-thiones Synthetic Comm. 2007, 37(1): 399-408.
  2006
  Lei M, Hu R J, Wang Y G,Mild and selective oxidation of alcohols to aldehydes and ketones using NaIO4/TEMPO/NaBr system under acidic conditions Tetrahedron 2006, 62(38): 8928-8932.
  Huang J Y, Lei M, Wang Y G, A novel and efficient ionic liquid supported synthesis of oligosaccharides Tetrahedron Lett. 2006, 47(18): 3047-3050.
  Lei M*, Tao X L, Wang Y G, A practical, water-soluble, ionic scavenger for the solution-phase syntheses of amides Helvetica Chimica Acta 2006, 89(3): 532-536.

  授权专利:

  1.微波辐射合成1,3-二取代眯唑-2-硫酮的方法(CN1300117)
  2.1,3-二取代眯唑-2-硫酮的微波合成方法(CN1294122)
  3. 溶液相组合合成酰胺和磺酰胺类化合物的纯化方法(CN100334067C)
  公开专利:
  (1) 18F标记肿瘤抑制剂Monastrol的前体化合物及制备方法和用途(CN101781259)
  (2) 一种三氮唑类化合物及其制备方法(CN 101768125A)
  (3) 4位-1H-1,2,3-三唑-β-内酰胺衍生物及其制备方法 (CN 101665509)
  (4) 4位-1H-1,2,3-三唑-β-内酰胺衍生物及制备方法 (CN101665508)
  (5) 一种制备含有脂肪醇羟基的芳香醛、酮的方法(CN101274882)

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