浙江大学医学院导师介绍:方马荣
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姓名:方马荣 性别:男 所在学院:医学院 职称:副教授
姓名:方马荣
性别:男
所在学院:医学院
职称:副教授
研究方向:
神经发育生物学和神经变性疾病
个人简介
89年和94毕业于浙江大学医学院获学士和硕士学位。
2005年毕业于浙江大学获理学博士学位,先后在香港中文大学(2003-2005、2006)作博士课题和博士后研究、香港大学分子生物学研究所作博士后研究(2008-2009)。
目前为浙大医学部基础系副教授,解剖和组织胚胎学兼跨细胞生物学专业硕士生导师。
96至97年在联邦德国吕贝克医科大学解剖所留学1年。2003--08年香港中文大学和香港大学访问学者。
是《Toxicology letters》,《Microscopy technique &Research》和《The Anatomical Record》等国际杂志审稿人。
已经发表SCI论文20余篇:
1. Fang M., Huang J., Ling SC., Rudd JA., Yew DT., Han S. Effects of Reg-2 on survival of spinal cord neurons in vitro. Anat Rec., 2010, 293(3):464-476.
2.Hu Z., Li Y., Fang M., Wai MS., Yew DT.Exogenous progesterone: a potential therapeutic candidate in CNS injury and neurodegeneration.Curr Med Chem. 2009, 16(11):1418-1425.
3.Fang M., Hu Z., Li Y., Li J., Yew DT., Ling S. Nestin positive cells in the retina and spinal cord of the sturgeon after hypoxia. Int J Neurosci., 2009, 119(4):460-470.
4) .Lü L., Mak YT., Fang M., Yew DT. The difference in gliosis induced by beta-amyloid and Tau treatments in astrocyte cultures derived from senescence accelerated and normal mouse strains. Biogerontology. 2009 Feb 17.
5. Xia H., Qi Y, Ng SS., Chen X., Chen S., Fang M., Li D., Zhao Y., Ge R., Li G., Chen Y., He ML., Kung HF., Lai L., Lin MC. MicroRNA-15b regulates cell cycle progression by targeting cyclins in glioma cells. Biochem Biophys Res Commun., 2009 Jan 9.
6.Fang M., Li J., Tiu SC., Zhang L., Wang M., Yew DT. N-methyl-D-aspartate receptor and apoptosis in Alzheimer\\\\\\\\\\\\\\\'s disease and multiinfarct dementia. J Neurosci Res., 2005, 81(2):269-274.
7.Fang M., Li J., Gong X., Lu G., Kwong WH., Wai SM., Yew DT.A fMRI study of age-related differential cortical patterns during cued motor movement. Brain Topogr.,2005, 17(3):127-137.
8.Fang M., Li J., Rudd JA., Wai SM., Yew JC., Yew DT. fMRI Mapping of cortical centers following visual stimulation in postnatal pigs of different ages. Life Sci., 2006, 78(11):1197-201.
9.Fang M., Li J., Gong X., Kwong WH., Lu G., Wai SM., Yew DT. Myenilation of the pig\\\\\\\\\\\\\\\'s brain: a correlated MRI and histological study. Neurosignals., 2005;14(3):102-108.
10.Fang M., Zhang L., Li J., Wang C., Chung CH., Wai SM., Yew DT. The postnatal development of the cerebellum- a FMRI and silver study. Cell Mol Neurobiol., 2005, 25(6):1043-1050.
11.Fang M., Lorke DE., Li J., Gong X., Yew JC., Yew DT. Postnatal changes in functional activities of the pig\\\\\\\\\\\\\\\'s brain: a combined functional magnetic resonance imaging and immunohistochemical study. Neurosignals., 2005,14(5):222-233.
12.Fang M., Li J., Kwong WH., Kindler P., Lu G., Wai SM., Yew DT. The complexity of the visual cells and visual pathways of the sturgeon. Microsc Res Tech. 2004;65 (3):122-129.
13.Fang M., Li J., Wai SM., Yew DT. Twin cones or double cones in fish-a misnomer or different morphological forms. Int J Neurosci., 2005, 115(7):981-987.
14.Gong X., Fang M., Wang J., Sun J., Zhang X., Kwong WH., Yew DT. Three-dimensional reconstruction of brain surface anatomy based on magnetic resonance imaging diffusion-weighted imaging: a new approach. J Biomed Sci., 2004, 11(6):711-6.
15.Lee FK., Fang M., Antonio GE., Yeung DK., Chan ET., Zhang LH., Yew DT., Ahuja AT. Diffusion Tensor Imaging (DTI) of in-vivo rodent brains with a 1.5T clinical MR-scanner. J Magn Reson Imaging., 2006, 23(5):747-751.
16.Lu G., Mak YT., Wai SM., Kwong WH., Fang M., James A., Randall D., Yew DT. Hypoxia-induced differential apoptosis in the central nervous system of the sturgeon (Acipenser shrenckii.Microsc Res Tech., 2005, 68(5):258-263.
17.Liang Y., Fang M., Li J., Yew DT. Immunohistochemical localization of endothelial isoform (eNOS) in human cerebral arteries and the aorta.Int J Neurosci., 2006, 116(12):1403-1417.
18.Liang Y., Fang M., Li J., Liu CB., Rudd JA., Kung HF., Yew DT. Serum proteomic patterns for gastric lesions as revealed by SELDI mass spectrometry. Exp Mol Pathol., 2006, 81(2):176-180.
19.Liang Y., Fang M., Li J., Wai MS., Lam WP., Yew DT. Vagus, hypoglossal, and median nerves in human development. Int J Neurosci., 2007, 117(4):453-464.
20.Lü LH., Li JC., Wai MS., Lam WP., Forster EL., Fang MR.,Yew DT. Perinatal hypoxia induces subsequent retinal degeneration in the offspring of ovoviviparous fish, Xiphophorous maculates. Vet Ophthalmol., 2007, 10(5):289-294.
研究方向:
主要研究兴趣为阿尔茨海默病(AD)脑衰老分子机制和IBS内脏感觉过敏机制。
研究手段:
1.神经元原代细胞培养和PC12、SK-N-SH细胞行为学观察;
2.荧光标记的LNA miRNAs探针原位杂交检测;
3.免疫荧光突触标记、激光共聚焦显微和免疫电镜的神经元形态学研究;
4.实时定量PCR法检测神经元miRNAs成熟体表达;
5.免疫印迹法测定;流式细胞仪检测凋亡率;
6. miRNAs基因沉默。
在开展的课题:
miRNAs对AD患者脑内神经元突触形态学影响的分子机制
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