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厦门大学化学系导师介绍:赵玉芬


   姓名: 赵玉芬
   性别: 女
   出生姓名:1948年12月
   职务:教授
   所获学位:博士
   授予单位:美国纽约州立大学石溪分校
   所属类别: 中国科学院院士
   研究方向:生命有机化学,有机磷化学,生命起源,药物化学,化学生物学
   学科专长:生命有机化学,有机磷化学,生命起源,药物化学,化学生物学
   E-mail:yfzhao@xmu.edu.cn 
   通信地址:厦门大学化学系
   邮编:361005
  
   个人中文简介
   1979-1988 中国科学院化学研究所副教授、教授
   1988-至今 清华大学化学系教授
   1993-2004 清华大学生命有机磷教育部开放实验室(2002年10月,更名为“生命有机磷化学及化学生物学教育部重点实验室”)主任
   1994-2004 清华大学生命科学与工程研究院副院长
   2000-至今 厦门大学化学化工学院教授
  
         研究领域:
   生命有机化学,有机磷化学,生命起源,药物化学,化学生物学
   
         发表文章:
   已在国际、国内刊物上发表300多篇论文,专利成果11项,并正在大力推进丙谷二肽项目的产业化。
  
  个人英文简介
   1979-1988 Associate Professor, then Professor of Chemistry, Institute of Chemistry,
   Academia Sinica Beijing, China
   1988- up to now Professor of chemistry, department of Chemistry, Tsinghua University,
   Beijing, China
   1993-2004 Director, Bioorganic Phosphorus Chemistry Lab., Beijing China
   1994-2004 Vice-dean, School of Life Science de Engineerings' Tsinghua University,
   Beijing, China
   2000- up to now Professor of chemistry, department of Chemistry, Xiamen University,
   Xiamen, China
   Research field:Bio-Organic Chemistry, Organo-phosphorous Chemistry, Origin of life,
   Medicinal Chemistry, Chemical Biology
   Publications:More than 300 papers, in the national and International Journals.
  
  代表性成果
  论文发表:
  (1)Synthesis of Hydroxycarboxylic Acids via Nickel(II)-Catalyzed Hydrogen Transfer Process,Adv. Synth. & Cata,2011年07月
  (2)Ni(II)/Zn Catalyzed Reductive Coupling of Aryl Halides with Diphenylphosphine Oxide in Water,ORGANIC LETTERS,2011年05月
  (3)Copper-Catalyzed C-P Bond Construction via Direct Coupling of Phenylboronic Acids with H-Phosphonate Diesters,ORGANIC LETTERS,2011年03月
  (4)Nickel-Catalyzed Cross-Coupling of Aryl Phosphates with Arylboronic Acids,J. Org. Chem.,2011年03月
  (5)Evaluation of non-covalent interaction between Seryl-Histidine dipeptide and cyclophilin A using NMR and molecular modeling,SCIENCE CHINA,2010年09月
  (6)THE SYNTHESIS OF AMINO ACID METHYL ESTER 5-PHOSPHOAMIDATES OF PROTECTED URIDINE,Phosphorus, Sulfur, and Silicon,2010年09月
  (7)Diastereomers of the pentacoordinate chiral phosphorus compounds in solution: absolute configurations and predominant conformations,Dalton Trans.,,2010年06月
  (8)Amino Acid Homochirality may be Linked to the Origin of Phosphate-Based Life,J Mol Evol,2010年05月
  (9)L-Valine assisted distinction between the stereo-isomers of D-hexoses by positive ion ESI tandem mass spectrometry,J. Mass. Spectrom.,2010年05月
  (10)Stereospecific Coupling of H-Phosphinates and Secondary Phosphine Oxides with Amines and Alcohols: A General Method for the Preparation of Optically Active Organophosphorus Acid Derivatives,J. Org. Chem.,2010年05月
  (11)Genome wide exploration of the origin and evolution of amino acids,BMC Evolutionary Biology 2010,2010年03月
  (12)Formation of cyclic acylphosphoramidates in mass spectra of N-monoalkyloxyphosphoryl amino acids using electrospray ionization tandemmass spectrometry,J. Mass. Spectrom.,2010年01月
  (13)Determination of the Absolute Configuration of Pentacoordinate Chiral Phosphorus Compounds in Solution by Using Vibrational Circular Dichroism Spectroscopy and Density Functional Theory,Chem. Eur. J.,2010年01月
  (14)Isolation and purification of macrocyclic components from Penicillium fermentation broth by high-speed counter-current chromatography,J. Sep. Sci.,2009年11月
  (15)A rapid HPLC/ESI-MS/MS method for quantitative analysis of isovalerylshikonin in rat plasma,Biomed. Chromatogr.,2009年08月
  (16)Copper-Catalyzed Aerobic Oxidative Coupling of Terminal Alkynes with H-Phosphonates Leading to Alkynylphosphonates,J. AM. CHEM. SOC.,2009年05月
  (17)N-phosphorylation of amino acids by trimetaphosphate in,Green Chemistry,2009年03月
  (18)On the Electrophilicity of Cyclic Acylphosphoramidates (CAPAs) Postulated as Intermediates,Eur. J. Org. Chem,2009年03月
  (19)A Novel and General Method for the Formation of S-Aryl, Se-Aryl, ,SYNTHESIS,2009年01月
  (20)Negative ion electrospray ionization mass spectrometry of nucleoside phosphoramidate monoesters: elucidation of novel rearrangement mechanisms by multistage mass spectrometry incorporating in-source deuterium labelling,RAPID COMMUNICATIONS IN MASS SPECTROMETRY,2008年10月
  (21)Novel N,S-phenacyl protecting group and its application for peptide synthesis,SYNLETT ,2008年07月
  (22)alpha-aminophosphonates as novel organocatalysts for asymmetric Michael addition of carbonyl compounds to nitroolefins,CHIRALITY,2008年07月
  (23)Alpha-Amino acid behaves differently from beta- or gamma-amino acids as treated by trimetaphosphate ,AMINO ACIDS,2008年01月
  (24)Synthesis and Crystal Structure of Diisopropyl Hydroxy (4-methoxyphenyl)methylphosphonate,J Chem Crystallogr,2008年01月
  (25)Application of (P-31)NMR in analyzing the degradation efficiency of organic phosphorus degrading-bacteria,ENVIRONMENTAL MONITORING AND ASSESSMENT,2007年07月
  (26)Study on [(4-substitutedbenzoylamino)-phenyl-methyl]-phosphonic acid diisopropyl esters under electrospray ionization tandem mass spectrometric conditions,Rapid Commun.Mass Spectrom.,2007年04月
  (27)Syntheses, characterizations, and crystal structures of phosphonopeptides ,HETEROATOM CHEMISTRY,2007年01月
  (28)Variation in proton affinity of the guanidino group between free and blocked arginine,Amino acids,2006年09月
  (29)Electrospray ionization mass spectrometry study on dipeptide 4-chlorobutyl ester produced from refluxing of amino acid with phosphoryl chloride in tetrahydrofuran,JOURNAL OF MASS SPECTROMETRY,2005年10月
  (30)Electrospray ionization tandem mass spectrometry investigation of the polymerization of tetrahydrofuran initiated by phosphorus oxychloride,EUROPEAN JOURNAL OF MASS SPECTROMETRY ,2005年08月
  (31){苯基一[(吡啶-4-羰基)-氨基]-甲基}-膦酸二烷基酯的合成与波谱表征,有机化学,2005年08月
  (32)Substituent effects and mechanism elucidation of enantioselective sulfoxidation catalyzed by vanadium Schiff base complexes,NEW JOURNAL OF CHEMISTRY,2005年07月
  (33)Analysis of the phosphoryl transfer mechanism of c-AMP dependent protein kinase (PKA)by penta-coodinate phosphoric transition state theory,CURRENT PROTEIN & PEPTIDE SCIENCE ,2005年07月
  (34)ESI-MS studies of hetro-peptide libraries by phosphorus oxychloride activation,INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS,2005年06月
  (35)Synthesis, characteristics and biological activity of pentacoordinated spirophosphoranes derived from amino acids,AMINO ACIDS,2005年05月
  (36)One pot conjugation of the polypeptides directed by phosphorus oxychloride,J. Peptide Res.,2005年01月
  (37)Electrospray ionization mass spectrometry: a powerful tool to investigate the oligomerization mechanism of tetrahydrofuran by phosphoryl chloride,Journal of Mass Spectrometry,2005年01月
  (38) 3,8-Dimethyl-1,6-dioxa-4,9-diaza-5[lambda]^{5}-phosphaspiro[4.4]nonane-2,7-dione,Acta Cryst. Sect.,2005年01月
  (39)31PNMR与HPLC技术联用筛选高效有机磷降解细菌,环境化学,2005年01月
  (40)Mycoediketopiperazine, a novel fungal metabolite form a popularia sp,Tetrahedron Letters,2005年01月
  
         专著发表:
  (1)磷与生活,郑州大学出版社,2008年01月,学术专著
  (2)生物有机质谱,郑州大学出版社,2005年10月,学术专著
  (3)磷与生命化学,清华大学出版社,2005年09月,学术专著
  
         获奖、专利和发明:
  (1)丙谷二肽合成方法,发明专利,2004年06月,中国国家知识产权局,等级:1
  (2)丙谷二肽合成方法,发明专利,2007年01月,美国专利,等级:1
    
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