四川大学生命科学学院导师介绍：曾凡亚

　　
　　姓名：曾凡亚　性别：男
　　职称：教授　学院：生命科学院
　
　　联系方式：***********，***********；
　　Email：zengfanya@scu.edu.cn
　　
　　学位简历和工作简历
　　1979.09 – 1983.07 四川大学，生物系，本科（获理学学士学位）
　　1983.07 – 1989.09 四川大学，生物系，助教
　　1989.10 – 1992.02 法国南巴黎大学，访问学者
　　1992.02 – 1994.08 四川大学，生物系，讲师
　　1994.09 – 1998.07 四川大学，生命科学学院，博士（获理学博士学位）
　　1998.07 – 2003.10 四川大学，生命科学学院，副教授
　　2003.10 – 2006.11 香港大学，动物学系，博士后
　　2006.11 – 2008.04 香港大学，生命科学学院，高级研究助理
　　2008.04 – 2012.02 四川大学，生命科学学院，教授
　　
　　研究方向
　　分子病毒学 — 沙士冠状病毒、猪繁殖与呼吸综合征病毒的基因组、遗传进化、疫苗免疫、和分子流行病学
　　
　　主持的研究项目
　　糙皮侧耳线粒体基因组全序列测定及基因组分析（国家自然科学基金2000-2002）
　　
　　发表文章
　　Yip CW, Hon CC, Shi M, Lam TT, Chow KY, Zeng F, Leung FC. Phylogenetic perspectives on the epidemiology and origins of SARS and SARS-like coronaviruses. Infect Genet Evol. 2009, 9(6):1185-96.
　　Lam TT, Hon CC, Pybus OG, Kosakovsky Pond SL, Wong RT, Yip CW, Zeng F, Leung FC. Evolutionary and transmission dynamics of reassortant H5N1 influenza virus in Indonesia. PLoS Pathog. 2008, 4(8):e1000130
　　Wang Y, Zeng F, Hon CC, Zhang Y, Leung FC. The mitochondrial genome of the Basidiomycete fungus Pleurotus ostreatus (oyster mushroom). FEMS Microbiol Lett. 2008, 280(1):34-41.
　　Hon CC, Lam TY, Shi ZL, Drummond AJ, Yip CW, Zeng F, Lam PY, Leung FC. Evidence of the recombinant origin of a bat severe acute respiratory syndrome (SARS)-like coronavirus and its implications on the direct ancestor of SARS coronavirus. J Virol. 2008, 82(4):1819-26.
　　Yeung YS, Yip CW, Hon CC, Chow KY, Ma IC, Zeng F, Leung FC. Transcriptional profiling of Vero E6 cells over-expressing SARS-CoV S2 subunit: Insights on viral regulation of apoptosis and proliferation. Virology. 2008, 371(1):32-43.
　　Lam TY, Hon CC, Wang Z, Hui RK, Zeng F, Leung FC. Evolutionary analyses of European H1N2 swine influenza A virus by placing timestamps on the multiple reassortment events. Virus Res. 2008, 131(2):271-8.
　　Wong RT, Hon CC, Zeng F, Leung FC. Screening of differentially expressed transcripts in infectious bursal disease virus-induced apoptotic chicken embryonic fibroblasts by using cDNA microarrays. J Gen Virol. 2007, 88:1785-96.
　　Yip CW, Hon CC, Zeng F, Chow KY, Chan KH, Peiris JS, Leung FC. Naturally occurring anti-Escherichia coli protein antibodies in the sera of healthy humans cause analytical interference in a recombinant nucleocapsid protein-based enzyme-linked immunosorbent assay for serodiagnosis of severe acute respiratory syndrome. Clin Vaccine Immunol. 2007, 14(1):99-101.
　　Zeng F, Hon CC, Yip CW, Law KM, Yeung YS, Chan KH, Malik Peiris JS, Leung FC. Quantitative comparison of the efficiency of antibodies against S1 and S2 subunit of SARS coronavirus spike protein in virus neutralization and blocking of receptor binding: implications for the functional roles of S2 subunit. FEBS Lett. 2006, 580(24):5612-20.
　　Yip CW, Yeung YS, Ma CM, Lam PY, Hon CC, Zeng F, Leung FC. Demonstration of receptor binding properties of VP2 of very virulent strain infectious bursal disease virus on Vero cells. Virus Res. 2007, 123(1):50-6.
　　Chow KY, Yeung YS, Hon CC, Zeng F, Law KM, Leung FC. Adenovirus-mediated expression of the C-terminal domain of SARS-CoV spike protein is sufficient to induce apoptosis in Vero E6 cells. FEBS Lett. 2005, 579(30):6699-704.
　　Hon CC, Lam TY, Drummond A, Rambaut A, Lee YF, Yip CW, Zeng F, Lam PY, Ng PT, Leung FC. Phylogenetic analysis reveals a correlation between the expansion of very virulent infectious bursal disease virus and reassortment of its genome segment B. J Virol. 2006, 80(17):8503-9.
　　Zeng F, Hon CC, Sit WH, Chow KY, Hui RK, Law IK, Ng VW, Yang XT, Leung FC, Wan JM. Molecular characterization of Coriolus versicolor PSP-induced apoptosis in human promyelotic leukemic HL-60 cells using cDNA microarray. Int J Oncol. 2005, 27(2):513-23.
　　Hui RK, Zeng F, Chan CM, Yuen KY, Peiris JS, Leung FC. Reverse transcriptase PCR diagnostic assay for the coronavirus associated with severe acute respiratory syndrome. J Clin Microbiol. 2004, 42(5):1994-9.
　　Zeng F, Chow KY, Hon CC, Law KM, Yip CW, Chan KH, Peiris JS, Leung FC. Characterization of humoral responses in mice immunized with plasmid DNAs encoding SARS-CoV spike gene fragments. Biochem Biophys Res Commun. 2004, 315(4):1134-9.
　　Guan Y, Peiris JS, Zheng B, Poon LL, Chan KH, Zeng FY, Chan CW, Chan MN, Chen JD, Chow KY, Hon CC, Hui KH, Li J, Li VY, Wang Y, Leung SW, Yuen KY, Leung FC. Molecular epidemiology of the novel coronavirus that causes severe acute respiratory syndrome. Lancet. 2004, 363(9403):99-104.
　　Zeng F, Chow KY, Leung FC. Estimated timing of the last common ancestor of the SARS coronavirus. N Engl J Med. 2003, 349(25):2469-70.
　　Zeng FY, Chan CW, Chan MN, Chen JD, Chow KY, Hon CC, Hui KH, Li J, Li VY, Wang CY, Wang PY, Guan Y, Zheng B, Poon LL, Chan KH, Yuen KY, Peiris JS, Leung FC. The complete genome sequence of severe acute respiratory syndrome coronavirus strain HKU-39849 (HK-39). Exp Biol Med (Maywood). 2003, 228(7):866-73.