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2019年华南师范大学脑科学与康复医学研究院导师介绍:刘镭

  ►联系地址

  华南师范大学脑科学与康复医学研究院

  广东省广州市中山大道西55号

  邮编:510631, 广州, 中国

  E-mail: liulei@scnu.edu.cn

  ►个人简介

  目前主要从事生物医学方向的基础科研工作:1. 细胞凋亡与肿瘤、帕金森症、老年痴呆等重大慢性疾病的密切关联;2. 线粒体功能紊乱在肿瘤、老年痴呆等重大疾病的预防与治疗中的作用;3. 先进的光学成像技术在生命科学中的应用;4. 中枢神经系统的发育与再生机制研究。自 2004 年以来,在这些研究方向取得了一些阶段性的研究成果,发表研究论文 30 余篇,多篇论文发表在 International Journal of Cancer, Cell Death and Disease, Free Radical Biology & Medicine, Antioxidants & Redox Signaling,Molecular Biology of The Cell, Cellular Signaling等国际知名学术期刊上。研究成果受到国内外同行的广泛关注,重要的研究成果被 Nature Reviews Cancer, Nature Chemical Biology, Genes &Development, Blood, Cancer Research 等权威学术期刊多次引用。

  ►教育及工作经历

  2004.09-2009.06       华南师范大学                             博士

  2009.07-2011.12      华南师范大学生物光子学研究院             讲师

  2012.01-2014.12      墨尔本大学                               博士后

  2015.01-2018.04        华南师范大学生物光子学研究院             副研究员

  2018.04-至今             华南师范大学脑科学与康复医学研究院       副研究员

  ►主持科研项目

  国家自然科学基金面上项目(基金号:31470072);

  国家自然科学基金青年基金项目(基金号:31101028);

  广东省自然科学基金自由申请项目 (基金号:2014A030313419)

  ►获奖

  2010.03,与所在研究团队一起获得广东省科学技术奖二等奖。获奖项目名称:光学与生命科学交叉科学中的前沿问题与关键技术研究。

  ►代表性论文

  1. Li Haolong, Lei Liu, Haocai Chang, Zou, Da Xing, “Downregulation of MCL-1 and upregulation of PUMA using mTOR inhibitors enhance antitumor efficacy of BH3 mimetics in triple-negative breast cancer.” Cell Death and Disease, 2018, 9: (137),1-15. (Corresponding author).

  2. Xiaotong Gu, Lei Liu, Qi Shen, Da Xing, “Photoactivation of ERK/CREB/VMAT2 pathway attenuates MPP+-induced neuronal injury in a cellular model of Parkinson's disease”, Cellular Signalling, 37, 103-114, 2017. (Corresponding author)

  3. Xianwang Wang, S. Hu, Lei Liu, “Phosphorylation and acetylation modifications of FOXO3a: Independently or synergistically?” Oncol. Lett. 13(5), 2867-2872, 2017. (Corresponding author)

  4. 常好才, 张真真,刘镭,“低功率光照疗法对机体免疫应答的影响” 生物化学与生物物理进展. 44(12)1074-1082,2017. (Corresponding author)

  5. Zhenzhen Zhang, Lei Liu, Shengnan Wu, Da Xing. “Drp1, Mff, Fis1, and MiD51 are coordinated to mediate mitochondrial fission during UV irradiation–induced apoptosis”, FASEB J, 30, 466-476, 2016.

  6. Zhenzhen Zhang, Lei Liu, Xiaoxiao Jiang, Shaodong Zhai, Da Xing. “The Essential Role of Drp1 and Its Regulation by S-Nitrosylation of Parkin in Dopaminergic Neurodegeneration: Implications for Parkinson’s Disease”, Antioxidants & Redox Signaling, 25(11), 609-622, 2016.

  7. Cuixia Lu, Feifan Zhou, Shengnan Wu, Lei Liu, Da Xing. “Phototherapy-induced antitumor immunity: long-term tumor suppression effects via photoinactivation of respiratory chain oxidase-triggered superoxide anion burst. Antioxidants & Redox Signaling, 24(5), 249-262, 2016.

  8. Jie Feng, Qinyan Sun, Lei Liu and Da Xing, Photoactivation of TAZ induces osteogenic differentiation via Akt/GSK3β signaling pathway, Int. J. Biochem. Cell Biol., 66, 59-68, 2015.

  9. Jiangang Liang, Lei Liu, and Da Xing, “Photobiomodulation by low power laser irradiation attenuates Aβ-induced cell apoptosis through Akt/GSK-3β/β-catenin pathway”, Free Radic. Biol. Med., 53(7), 1459-1467, 2012.

  10. Lei Liu, Zhen-Zhen Zhang, and Da Xing, “Activation of Bax by lysosomal photodamage induces cell death via mitochondrial apoptotic pathway”, Free Radic. Biol. Med., 51, 53-68, 2011.

  11. Hui Li, Lei Liu, and Da Xing, Wei R. Chen, “Inhibition of JNK/Bim pathway by HSP70 prevents Bax activation in UV-induced apoptosis”, FEBS Lett., 584, 4672-4678, 2010.

  12. Lei Liu, Da Xing, and Wei R. Chen, “μ-Calpain mediates caspase-dependent and-independent apoptotic pathways in cisplatin-induced apoptosis”, Int. J. Cancer, 125, 2757-2766, 2009.

  13. Lei Liu, Yingjie Zhang, Xianwang Wang, “Using FRET technique to investigate the apoptotic mechanism induced by cisplatin in living cells”, Prog. Biochem. Biophys. 36 (9), 1172-1176, 2009.

  14. Yingjie Zhang, Da Xing, and Lei Liu, “PUMA promotes Bax translocation by both directly activating Bax and antagonizing Bcl-XL during UV-induced apoptosis”, Mol. Biol. Cell, 3077-3087, 2009.

  15. Xuejuan Gao, Da Xing, Lei Liu, and Yonghong Tang, “H-Ras and PI3K are required for the formation of circular dorsal ruffles induced by low power laser irradiation”, J. Cell. Physiol., 219, 535-543, 2009.

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