2019年华南师范大学脑科学与康复医学研究院导师介绍：刘镭

　　►联系地址

　　华南师范大学脑科学与康复医学研究院

　　广东省广州市中山大道西55号

　　邮编：510631, 广州, 中国

　　E-mail: liulei@scnu.edu.cn

　　►个人简介

　　目前主要从事生物医学方向的基础科研工作：1. 细胞凋亡与肿瘤、帕金森症、老年痴呆等重大慢性疾病的密切关联；2. 线粒体功能紊乱在肿瘤、老年痴呆等重大疾病的预防与治疗中的作用；3. 先进的光学成像技术在生命科学中的应用；4. 中枢神经系统的发育与再生机制研究。自 2004 年以来，在这些研究方向取得了一些阶段性的研究成果，发表研究论文 30 余篇，多篇论文发表在 International Journal of Cancer, Cell Death and Disease, Free Radical Biology & Medicine, Antioxidants & Redox Signaling，Molecular Biology of The Cell, Cellular Signaling等国际知名学术期刊上。研究成果受到国内外同行的广泛关注，重要的研究成果被 Nature Reviews Cancer, Nature Chemical Biology, Genes &Development, Blood, Cancer Research 等权威学术期刊多次引用。

　　►教育及工作经历

　　2004.09-2009.06       华南师范大学                             博士

　　2009.07-2011.12      华南师范大学生物光子学研究院             讲师

　　2012.01-2014.12      墨尔本大学                               博士后

　　2015.01-2018.04        华南师范大学生物光子学研究院             副研究员

　　2018.04-至今             华南师范大学脑科学与康复医学研究院       副研究员

　　►主持科研项目

　　国家自然科学基金面上项目（基金号：31470072）；

　　国家自然科学基金青年基金项目（基金号：31101028）；

　　广东省自然科学基金自由申请项目 （基金号：2014A030313419）

　　►获奖

　　2010.03，与所在研究团队一起获得广东省科学技术奖二等奖。获奖项目名称：光学与生命科学交叉科学中的前沿问题与关键技术研究。

　　►代表性论文

　　1. Li Haolong, Lei Liu, Haocai Chang, Zou, Da Xing, “Downregulation of MCL-1 and upregulation of PUMA using mTOR inhibitors enhance antitumor efficacy of BH3 mimetics in triple-negative breast cancer.” Cell Death and Disease, 2018, 9: (137),1-15. (Corresponding author).

　　2. Xiaotong Gu, Lei Liu, Qi Shen, Da Xing, “Photoactivation of ERK/CREB/VMAT2 pathway attenuates MPP+-induced neuronal injury in a cellular model of Parkinson's disease”, Cellular Signalling, 37, 103-114, 2017. (Corresponding author)

　　3. Xianwang Wang, S. Hu, Lei Liu, “Phosphorylation and acetylation modifications of FOXO3a: Independently or synergistically?” Oncol. Lett. 13(5), 2867-2872, 2017. (Corresponding author)

　　4. 常好才, 张真真，刘镭，“低功率光照疗法对机体免疫应答的影响” 生物化学与生物物理进展. 44（12）1074-1082，2017. (Corresponding author)

　　5. Zhenzhen Zhang, Lei Liu, Shengnan Wu, Da Xing. “Drp1, Mff, Fis1, and MiD51 are coordinated to mediate mitochondrial fission during UV irradiation–induced apoptosis”, FASEB J, 30, 466-476, 2016.

　　6. Zhenzhen Zhang, Lei Liu, Xiaoxiao Jiang, Shaodong Zhai, Da Xing. “The Essential Role of Drp1 and Its Regulation by S-Nitrosylation of Parkin in Dopaminergic Neurodegeneration: Implications for Parkinson’s Disease”, Antioxidants & Redox Signaling, 25(11), 609-622, 2016.

　　7. Cuixia Lu, Feifan Zhou, Shengnan Wu, Lei Liu, Da Xing. “Phototherapy-induced antitumor immunity: long-term tumor suppression effects via photoinactivation of respiratory chain oxidase-triggered superoxide anion burst. Antioxidants & Redox Signaling, 24(5), 249-262, 2016.

　　8. Jie Feng, Qinyan Sun, Lei Liu and Da Xing, Photoactivation of TAZ induces osteogenic differentiation via Akt/GSK3β signaling pathway, Int. J. Biochem. Cell Biol., 66, 59-68, 2015.

　　9. Jiangang Liang, Lei Liu, and Da Xing, “Photobiomodulation by low power laser irradiation attenuates Aβ-induced cell apoptosis through Akt/GSK-3β/β-catenin pathway”, Free Radic. Biol. Med., 53(7), 1459-1467, 2012.

　　10. Lei Liu, Zhen-Zhen Zhang, and Da Xing, “Activation of Bax by lysosomal photodamage induces cell death via mitochondrial apoptotic pathway”, Free Radic. Biol. Med., 51, 53-68, 2011.

　　11. Hui Li, Lei Liu, and Da Xing, Wei R. Chen, “Inhibition of JNK/Bim pathway by HSP70 prevents Bax activation in UV-induced apoptosis”, FEBS Lett., 584, 4672-4678, 2010.

　　12. Lei Liu, Da Xing, and Wei R. Chen, “μ-Calpain mediates caspase-dependent and-independent apoptotic pathways in cisplatin-induced apoptosis”, Int. J. Cancer, 125, 2757-2766, 2009.

　　13. Lei Liu, Yingjie Zhang, Xianwang Wang, “Using FRET technique to investigate the apoptotic mechanism induced by cisplatin in living cells”, Prog. Biochem. Biophys. 36 (9), 1172-1176, 2009.

　　14. Yingjie Zhang, Da Xing, and Lei Liu, “PUMA promotes Bax translocation by both directly activating Bax and antagonizing Bcl-XL during UV-induced apoptosis”, Mol. Biol. Cell, 3077-3087, 2009.

　　15. Xuejuan Gao, Da Xing, Lei Liu, and Yonghong Tang, “H-Ras and PI3K are required for the formation of circular dorsal ruffles induced by low power laser irradiation”, J. Cell. Physiol., 219, 535-543, 2009.