中国海洋大学海洋生命学院导师介绍：王晓飞

　　王晓飞，男，1956年生。1982年本科毕业于山东大学。1983-1998年在青岛的企业、机关及高新技术产业开发区从事技术和管理工作。1998-2002年赴香港中文大学生理系攻读硕/博士，获得哲学博士学位。2002-2005年在美国加利福尼亚大学圣地亚哥分校做博士后研究。2006年起任中国海洋大学海洋生命学院教授。
　　
　　1998年以来，一直从事上皮细胞生理、生殖生理方面的研究。2003-2005年承担关于上皮细胞离子通道转运与CF肺病发病机制的研究课题，获得美国 Elizabeth Nash Memorial Post Doctoral Fellowship 研究基金支持。2007-2009年主持关于 “气道上皮CFTR调控的离子转运和免疫防御” 研究课题分别获得国家自然科学基金和山东省自然科学基金的支持。多年来在国外生物医学SCI刊物上发表论文20余篇，其中影响因子3.0以上的10篇。2003年参加编著学术专著《外分泌生理学》（科学出版社）。
　　
　　研究方向 上皮细胞生理，离子通道转运，信号转导，生殖生理
　　最近课题 CFTR阴离子通道介导的上皮转运与免疫防御
　　
　　主要论文
　　1. X.F. Wang, Q.X. Shi, Y.Y. Yuan, C.X. Zhou, M.K. Yu, L.C. Ajonuma, L.N. Chan, P.S. Lo, W.C. Zhao, Y.W. Chung & H.C. Chan. Involvement of CFTR in uterine bicarbonate secretion and the fertilizing capacity of sperm. Nature Cell Biology 5(10):902-6. (2003, Impact Factor 20.3)
　　2. XIE Chen, WANG Xiao-Fei*, QI Xiu-Juan, LU Li-Li, CHAN Hsiao-Chang. Effect of Huoxiang-zhengqi liquid on HCO3- secretion by intact porcine distal airway epithelium. Acta Physiologica Sinica, 25,60 (1): 90-96 (2008)
　　3. Xu WM, Shi QX, Chen WY, Zhou CX, Ni Y, Rowlands DK, Yi Liu G, Zhu H, Ma ZG, Wang XF, Chen ZH, Zhou SC, Dong HS, Zhang XH, Chung YW, Yuan YY, Yang WX, Chan HC. Cystic fibrosis transmembrane conductance regulator is vital to sperm fertilizing capacity and male fertility. Proc Natl Acad Sci U S A. 5;104(23):9816-21.(2007) (2006IF9.6)
　　4. CHAN Hsiao-Chang, HE Qiong, AJONUMA Louis-Chukwuemeka, WANG Xiao-Fei. Epithelial ion channels in the regulation of female reproductive tract fluid microenvironment: implications in fertility and infertility. Acta Physiologica Sinica, 25, 59 (4): 495-504 (2007)
　　5. Chan HC, Shi QX, Zhou CX, Wang XF, Xu WM, Chen WY, Chen AJ, Ni Y, Yuan YY. Critical role of CFTR in uterine bicarbonate secretion and the fertilizing capacity of sperm. Mol Cell Endocrinol 16;250(1-2):106-13. (2006, IF2.8)
　　6. M.M. Reddy, X.F. Wang, M. Gottschalk, K. Jones, P.M. Quinton. Normal CFTR Activity and Reversed Skin Potentials in Pseudohypoaldosteronism. J Membrane Biol 203(3):151-9 (2005, IF3.2)
　　7. X.F.Wang, C. Lytle, and P.M. Quinton. Predominant Constitutive CFTR Conductance in Small Airways. Respiratory Research 6(1):7. (2005, IF2.7)
　　8. X.F. Wang, M.M. Reddy, P.M. Quinton. Effects of a New CFTR Inhibitor on Cl- Conductance in a Native Human Epithelium. Experimental Physiology 89(4):417-25. (2004)
　　9. X.F. Wang, M.K. Yu, S.Y. Lam, K.M. Leung, J.L. Jiang, P.S. Leung, W.H. Ko, P.Y. Leung, S.B.C. Chew, C.Q. Liu, C.M. Tse & H.C. Chan. Expression, Immunoloca-lization and functional activity of Na+/H+ exchanger isoforms in mouse endometrial epithelium. Biology of Reproduction 68(1):302-8. (2003, IF3.6)
　　10. Wang XF, Yu MK, Leung KM, Yip CY, Ko WH, Liu CQ, Chan HC. Involvement of Na+-HCO3- cotransporter in mediating cyclic adenosine 3',5'-monophosphate-dependent HCO3- secretion by mouse endometrial epithelium. Biology of Reproduction 66(6):1846-52. (2002, IF3.6)
　　11. Chan LN, Wang XF, Tsang LL, So SC, Chung YW, Liu CQ, Chan HC. Inhibition of amiloride-sensitive Na+ absorption by activation of CFTR in mouse endometrial epithelium. Pflugers Archiv European Journal of Physiology 443 Suppl 1:S132-6. (2001, IF2.1)
　　12. Wang XF, Tsang LL, So SC, Chan HC. Suppression of ATP-induced Cl- secretion by enhanced expression of epithelial Na+ channels in mouse endometrial epithelium. Cell Biology International 25(10):1017-20. (2001)
　　13. X.F.Wang and H.C.Chan. Adenosine triphosphate induced inhibition of Na+ absorption in mouse endometrial epithelium: A Ca2+-dependent mechanisms. Biology of Reproduction 63:1918-1924. (2000, IF3.6)
　　14. L.N.Chan, X.F.Wang, L.L.Tsang, C.Q.Liu, and C.H.Chan. Suppression of CFTR-mediated Cl- secretion by enhanced expression of epithelial Na+ channels in mouse endometrial epithelium. Biochemical and Biophysical Research Communications 276:40-44. (2000, IF2.8)
　　15. L.N.Chan, X.F.Wang, L.L.Tsang, H.C.Chan. Pyrimidinoceptors-mediated activation of Ca2+-dependent Cl- conductance in mouse endometrial epithelial cells. Biochimica et Biophysica Acta 1497(2):261-70. (2000, IF3.5)
　　16. H.C.Chan, W.L.Wu, D.C.So, Y.W.Chung, L.L.Tsang, X.F.Wang, Y.C.Yan, S.C.W.Luk, S.S.Siu, S.K.W.Tsui, K.P.Fung, C.Y.Lee and M.Y.Waye. Modulation of the Ca2+-activated Cl- channel by 14-3-3e. Biochemical and Biophysical Research Communications 270(2):581-7. (2000, IF2.8)
　　17. H.S.Cheng, W.S.Wong, K.T.Chan, X.F.Wang, Z.D.Wang, H.C.Chan. Modulation of Ca2+-dependent anion secretion by protein kinase C in normal and cystic fibrosis pancreatic duct cells. Biochimica et Biophysica Acta 14;1418(1):31-8. (1999, IF3.5)
　　18. C.Y.Ceung, X.F.Wang, H.C.Chan. Stimulation of HCO3- secretion across cystic fibrosis pancreatic duct by extracellular ATP. Biological Signals and Receptors 7(6):321-7. (1998，IF3.5)
　　
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