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中国海洋大学博士研究生导师介绍:朱伟明

姓  名:
朱伟明
性别:
出生年月:
1965-02
工作单位:
中国海洋大学
所在院系:
医药学院
职称:
教授
行政职务:
招生专业:
研究领域:
海洋天然药物
是否兼职:
指导博士生总数:
指导硕士生总数:
目前博士生数:
目前硕士生数:
  个人简介

  朱伟明,男,1965年2月生,博士、教授、博士生导师,主要从事海洋天然药物研究。已完成主持承担的国家863计划、国家自然科学基金、大洋协会开发计划等国家级研究课题4项,目前主持在研的课题3项。已培养硕士6名、博士1名,协助培养硕士18名、博士9名、博士后1名;在读硕士生8名、博士生6名。已发表学术研究论文112篇,其中SCI收录60篇;申请国家发明专利16项(授权6项)。

  研究领域 Research field:

  从海洋微生物资源中发掘创新药物先导化合物To discovery new hits and lead compounds from marine-derived microbes and halotolerant microorganisms by means of integrated screening methods

  利用生物学与化学相结合的集成筛选方法,从海洋微生物、极端环境微生物中筛选并发现具有重要生物活性的药物先导化合物及药用新资源。

  中药药理作用的物质基础研究Investigations of pharmacological compounds in the traditional Chinese medicine

  与药理学家合作,研究传统中药的物质基础,发现其有效成分。

  天然药物的优化 To discovery new leads by structural modification of new hits

  对具有重要生物活性的天然产物进行结构修饰,探讨其构效关系,获得临床候选药物。

  研究小组成员 Research team:

  王乂(博士,讲师)、刘培培(学士、工程师)

  博士生:张亚鹏、陶洪文、卢圳域、郑金铠、庄以彬、彭晓娉

  硕士生:韩秀丽、王慧、周雅琳、杨春丽、滕宪存、徐志宏、付鹏、王心

  研究课题 Research programs:

  “PKC靶向抗癌候选药物ACT-007的研究与开发”(No. 2007AA091502, 2007–2010,863重点课题,主持人)Research and development of the new anticancer candidate, ACT-007 with PKC inhibition (The National High Technology Research and Development Program).

  “嗜盐微生物抗肿瘤活性成分的研究”(No. 30670219, 2007–2009,国家自然科学基金,主持人)。Studies on the anti-tumor constituents from the halophilic and halotolerant microorganisms (National Natural Science Foundation of China).

  “新的蛋白激酶C抑制剂ACT-007衍生物的合成及其抗癌构效关系研究”(No. 30572246, 2006–2008,国家自然科学基金,主持人)。Synthesis of the derivatives of the new PKC inhibitor, ACT-007 and their anti-tumor structure-active relationship studies (National Natural Science Foundation of China).

  “海洋微生物中抗癌等活性先导化合物的发现和优化”(No. 2003AA624020, 2003–2005,863计划,主持人,已通过验收)。Discovery of leading compounds with anti-tumor activities from marine-derived microorganisms (The National High Technology Research and Development Program).

  “嗜盐微生物抗肿瘤活性成分的探索性研究”(No. 30470196, 2004–2005,国家自然科学基金,主持人,已结题)。Primary studies on the antitumor constituents of halophiles (National Natural Science Foundation of China).

  作为主要骨干参与的课题:①“深海微生物药物先导化合物的高通量筛选与发现”(No. DY105-2-04-02,2004–2005,大洋矿产协会,排名第3,已结题),Discovery of leading compounds from microorganisms derived from the deep sea samples by high throughput screening (Research Program of China Ocean Mineral Resources R & D Association);②“海洋药物研究开发的平台技术”(No. 2004AA621020,2004–2006,863专项,排名第4,已结题),Basic Technology for research and development of Marine Drugs (The National High Technology Research and Development Program);③“海洋药用生物资源评价和《中华海洋本草》编纂”(No. 908-02-05-04,2005–2009,908专项,排名第9)。

  教育背景 Educational background:

  1981–1985年:武汉大学化学系,毕业并获得理学学士学位。B.Sc. in Chemistry from Wuhan University

  1985–1988年:武汉大学化学系,毕业并获得理学硕士学位。M.S. in Organic Chemistry from Wuhan University

  1997–2001年:中科院昆明植物研究所,毕业并获得理学博士学位。 Ph. D. in Natural Products from Kunming Institute of Botany, Chinese Academy of Science

  2001–2003年:中国科学院上海有机化学研究所博士后,从事活性产物喷脑皂甙元及其衍生物合成研究。Postdoctoral research in Organic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science.

  著作及论文

  代表性成果 Selected Publications:

  1.        Wei-Ming Zhu, Tapping Chemodiversity of Halotolerant Fungal Metabolites for Drug Discovery(邀请报告), 17th GORDON RESEARCH CONFERENCES on marine natural products, 26 Feb 2008, Ventura California, USA

  2.        Wenliang Wang, Tianjiao Zhu, Hongwen Tao, Zhenyu Lu, Yuchun Fang, Qianqun Gu, Weiming Zhu, Three Novel, Structurally Unique Spirocyclic Alkaloids from the Halotolerant B-17 Fungus strain of Aspergillus variecolor, Chemistry & Biodiversity 2007, 4(12): 2913-2919.

  3.        Lin Du, Tianjiao Zhu, Yuchun Fang, Qianqun Gu, and Weiming Zhu, Unusual C25 Steroid Isomers with Bicyclo[4.4.1]A/B Rings from a Volcano Ash-Derived Fungus Penicillium citrinum, J. Nat. Prod. 2008, 71 (8): 1343-1351.

  4.        Rui Liu, Zhenjian Lin, Tianjiao Zhu, Yuchun Fang, Qianqun Gu, Weiming Zhu, Novel Open-Chain Cytochalsins from the Marine-Derived Fungus Spicaria elegans. J. Nat. Prod. 2008, 71 (7): 1127-1132.

  5.        Min Zhang, Wen-Liang Wang, Yu-Chun Fang, Tian-Jiao Zhu, Qian-Qun Gu, Wei-Ming Zhu, Cytotoxic Alkaloids and Antibiotic nor-Dammarane Triterpenoids from Marine-Derived Fungus Aspergillus sydowi. J. Nat. Prod. 2008, 71 (6): 985-989.

  6.        Zhen-Yu Lu, Zhen-Jian Lin, Wen-Liang Wang, Lin Du, Tian-Jiao Zhu, Yu-Chun Fang, Qian-Qun Gu, Wei-Ming Zhu, Citrinin Dimers from the Halotolerant Fungus Penicillium citrinum B-57, J. Nat. Prod. 2008, 71 (4): 543-546.

  7.        Li Chen, Yuchun Fang, Tianjiao Zhu, Qian-Qun Gu, Wei-Ming Zhu, Nine New Gentisyl Alcohol Derivatives from Marine-derived Fungus Penicillium terrestre, J. Nat. Prod. 2008, 71 (1): 66-70.

  8.        Fazuo Wang, Yuchun Fang, Tianjiao Zhu, Min Zhang, Aiqun Lin, Qianqun Gu, Weiming Zhu, Seven new prenylated indole diketopiperazine alkaloids from holothurian-derived fungus Aspergillus fumigatus, Tetrahedron 2008, 64(34): 7986-7991.

  9.        Wen-Liang Wang, Zhen-Yu Lu, Hong-Wen Tao, Tian-Jiao Zhu, Yu-Chun Fang, Qian-Qun Gu, Wei-Ming Zhu, Isoechinulin-type Alkaloids, Variecolorin A-L, from Halotolerant Aspergillus variecolor, J. Nat. Prod. 2007, 70 (9): 853-855.

  10.   Zhi Hong Xin, Yuchun Fang, Lin Du, Tianjiao Zhu, Lin Duan, Juan Chen, Qian-Qun Gu, Wei-Ming Zhu, Aurantiomides A-C, Quinazoline Alkaloids from the Sponge- Derived Fungus Penicillium aurantiogriseum SP0-19, J. Nat. Prod. 2007, 70 (5): 853-855.

  11.   Rui Liu, Qianqun Gu, Weiming Zhu, Chengbin Cui, Guotao Fan, Yuchun Fang, Tianjiao Zhu, Hongbing Liu. 10-Phenyl-[12]-cytochalasins Z7, Z8, and Z9 from the marine-derived fungus Spicaria elegans. J. Nat. Prod. 2006, 69(6): 871-875.

  12.   Dehai Li, Fengping Wang, Xiang Xiao, Yuchun Fang, Tianjiao Zhu, Qianqun Gu, Weiming Zhu, Trisorbicillinone A, a novel sorbicillin trimer, from a deep sea fungus, Phialocephala sp. FL30r, Tetrahedron Lett. 2007, 48(30): 5235-5238.

  13.   Yapeng Zhang, Tianjiao Zhu, Yuchun Fang, Hongbing Liu, Qianqun Gu, Weiming Zhu, Carbonarones A and B, New Bioactive gamma-Pyrone and alpha-Pyridone Derivatives from the Marine-derived Fungus Aspergillus carbonarius, J. Antibiot. 2007, 60(2): 153-157.

  14.   Li Chen, Yuchun Fang, Xiaodong Luo, Hongping He, Tianjiao Zhu, Hongbing Liu, Qianqun Gu, Weiming Zhu, Three New Sulfated Alkenes from the Echinus Temnopleurus hardwickii, J. Nat. Prod. 2006, 69 (12): 1787-1789.

  15.   Weizhong Liu, Qianqun Gu, Weiming Zhu, Chengbin Cui, Guotao Fan, Tianjiao Zhu, Hongbing Liu, Yuchun Fang,Penicillones A and B, two novel polyketides with tricyclo [5.3.1.03,8] undecane skeleton, from a marine-derived fungus Penicillium terrestre. Tetrahedron Lett. 2005, 46 (30): 4993-4996.

  16.   Wei Ming Zhu, Chun Hua Lu, Yue Wang, Jun Zhou, Xiao Jiang Hao, Monoterpenoids and Their Glycosides from Winchia calophylla, J. Asian Nat. Prod. Res. 2004, 6 (3): 193–198.

  17.   Wei-Ming Zhu, Hua-Jie Zhu, Wei-Sheng Tian, Xiao-Jiang Hao and Charles U. Pittman Jr., The Selective Dehydroxylation of 20-Hydroxy ecdysone by Zn Powder and Anhydrous Acetic Acid, Synthetic Comm. 2002, 32 (9): 1385-1391.

  18.   Wei Ming Zhu, Shun Lin Li, Yue Mao Shen, Xian Jiang Ning, Bi Tao Zhao, and Xiao Jiang Hao, The sesquiterpenoid from Polyalthia cheliensis Hu, Heterocycles, 2002, 57(3): 529-534.

  19.   朱伟明,谢笑天,吴增元,《有机化学学习技巧》,云南科技出版社,1995年。Zhu Weiming, Xie Xiaotian, Wu Zengyuan, “Some Methods for Learning Organic Chemistry”, Yunnan Press of Science and Technology, 1995.

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