南通大学航海医学研究所导师介绍：吴小梅

　　吴小梅，1969年7月，博士，硕士生导师。主要从事脑缺血损伤的防治与神经退行性疾病分子机制的研究，讲授生物化学和分子生物学理论和实验课程。主持和参加多项各级课题的研究，发表学术论文20余篇。

　　发表的代表性论文：

　　Wu X, Qian ZM, Zhu L, Du F, Yung WH, Gong Q, Ke Y. (2011) Neuroprotective effect of ligustilide against ischemia-reperfusion injury via up-regulation of erythropoietin and down-regulation of RTP801. British Journal of Pharmacology. 2011, 164: 332–343.

　　Wu X, Qian Z, Ke Y, Du F, Zhu L. (2009) Ginkgolide B preconditioning protects neurons against ischaemia-induced apoptosis. J Cell Mol Med. 13:4474-4483.

　　Du F, Wu X, Gong Q, He X, Ke Y. (2011) Hyperthermia conditioned astrocyte-cultured medium protects neurons from ischemic injury by the up-regulation of HIF-1 alpha and the increased anti-apoptotic ability. Eur J Pharmacol. 666:19-25.

　　Qian ZM, Wu X, Fan M, Yang L, Du F, Yung WH, Ke Y. (2011) Divalent metal transporter 1 is a hypoxia-inducible gene. J Cell Physiol. 226:1596-1603.

　　Zhao W, Wu X, Xie H, Ke Y, Yung WH. (2010) Permissive role of insulin in the expression of long-term potentiation in the hippocampus of immature rats. Neurosignals. 18:236-245.

　　Zhu L, Wu X, Yang L, Du F, Qian ZM. (2007) Up-regulation of HIF-1alpha expression induced by ginkgolides in hypoxic neurons. Brain Res. 1166C:1-8.

　　Zhu L, Ke Y, Wu X, Lei Y, Yang L, Qian ZM. (2008) Ginkgolides protect PC12 cells against hypoxia-induced injury by p42/p44 MAPK pathway-dependent upregulation of HIF-1alpha expression and HIF-1DNA-binding activity. J Cell Biochem. 103: 564-575.

　　Du F, Qian C, Qian ZM, Wu X, Xie H, Yung WH, Ke Y. (2011) Hepcidin directly inhibits transferrin receptor 1 expression in astrocytes via a cyclic AMP-protein kinase a pathway. Glia. 59:936-945.

　　Du F, Zhu L, Qian ZM, Wu X, Yung WH, Ke Y. (2010) Hyperthermic preconditioning protects astrocytes from ischemia/reperfusion injury by up-regulation of HIF-1 alpha expression and binding activity. Biochim Biophys Acta. 1802:1048-1053.

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