南通大学航海医学研究所导师介绍:高永静
高永静,神经生物学专业博士,硕士研究生导师,教授,航海医学研究所副所长,江苏特聘教授。1995年毕业于南通医
高永静,神经生物学专业博士,硕士研究生导师,教授,航海医学研究所副所长,江苏特聘教授。1995年毕业于南通医学院临床医学专业,并被免试推荐为人体解剖学专业硕士研究生(导师:凌树才教授,现工作于浙江大学医学院),1999年获硕士学位。2004年获得复旦大学神经生物学博士学位(导师:赵志奇教授)。2006年5-12月在美国圣路易斯华盛顿大学医学院进行博士后工作。2007年1月至2010年10月在美国哈佛大学医学院工作。2010年11月回国。近五年来,在SCI收录的期刊上发表论文近30篇,总影响因子140多,发表的论文被SCI收录期刊引用600余次;主持完成国家自然科学基金一项、江苏省高校自然科学研究计划项目一项,参与完成多项国家自然科学基金课题、美国NIH课题。目前主持研究国家自然科学基金面上项目一项、江苏省自然科学基金一项。2004年被评为江苏省“青蓝工程”优秀青年骨干教师;2005年被评为南通大学优秀教育工作者,同年获江苏省科技进步三等奖、南通市科技进步二等奖一项(排名第二);2009年入选教育部新世纪优秀人才支持计划、2010年获南通市青年科技奖;2011年入选江苏省“333”工程第三层次人才、南通市“226”工程第二层次人才,担任中华医学会疼痛学分会基础组委员会委员、中华医学会航海医学分会青年副主任委员、中国神经科学会感觉和运动分会委员、胶质细胞分会委员、江苏省疼痛学会青年委员。多次参加国家自然科学基金项目青年基金项目和面上项目评审,担任《Pain》、《Glia》、《PLoS One》、《Journal of Neuroinflammation》、《Journal of Pain》、《Anesthesia and Analgesia》等近20种疼痛和神经科学领域国际专业杂志审稿专家。
研究方向:
胶质细胞参与慢性疼痛调节的机制;特殊环境下疼痛的传递和调制。
研究团队:
本课题组成员中有具有博士学位的研究人员3名、具有硕士学位的青年教师4名、硕士研究生7名。课题组成员年富力强,具有团结协作精神和对科研工作的浓厚兴趣,是一个奋发向上、朝气蓬勃的集体。
主要通讯作者和第一作者论文
1. Jie Hui, Zhi-Jun Zhang, Xin Zhang, Yan Shen, Yong-Jing Gao*.Repetitive hyperbaric oxygen treatment attenuates complete Freunds adjuvant-induced pain and reduces glia-mediated neuroinflammation in the spinal cord.Journal of Pain, accepted, 2013
2. Zhi-Jun Zhang, Yu-Lin Dong, Ying Lu, Zhi-Qi Zhao, Yong-Jing Gao*.Chemokine CCL2 and its receptor CCR2 in the medullary dorsal horn are involved in trigeminal neuropathic pain.Journal of Neuroinflammation.2012, July 9, 9:136
3. Zhi-Jun Zhang, Lin-Xia Zhao, De-Li Cao, Xin Zhang, Yong-Jing Gao*, Chunlin Xia. Curcumin inhibits LPS-induced CCL2 expression via JNK pathway in C6 rat astrocytoma cells.Cellular and Molecular Neurobiology.2012 Aug;32(6):1003-1010
4. Feng-Li Chen, Yu-Lin Dong, Zhi-Jun Zhang, De-Li Cao, Jie Xu, Jie Hui, Li Zhu, Yong-Jing Gao*.Activation of astrocytes in the anterior cingulate cortex contributes to the affective component of pain in an inflammatory pain model.Brain Research Bulletin, 2012,4;87(1):60-6
5. Ying Lu, Li Zhu, Yong-Jing Gao*.Pain related aversion induced astrocytes activation and proinflammatory cytokines expression in rat anterior cingulate cortex.Brain Research Bulletin.2011, 84(2):178-82.
6. Yong-Jing Gao* and Ru-Rong Ji*.Light touch induces ERK activation in superficial dorsal horn neurons after inflammation: involvement of spinal astrocytes and JNK signaling in touch-evoked central sensitization and mechanical allodynia.Journal of Neurochemistry.2010, 115(2):505-14.
7. Yong-Jing Gao*, -activated astrocytesaLing Zhang, Ru-Rong Ji*.Spinal injection of TNF- produces persistent pain symptom mechanical allodynia by releasing monocyte chemoattractant protein-1 to induce sensitization of dorsal horn neurons.Glia.2010,58(15):1871-80.
8. Yong-Jing Gao*, Ru-Rong Ji*.Targeting Astrocyte Signaling for Chronic Pain Management.Neurotherapeutics.2010, 7(4):482-93
9. Yong-Jing Gao*, Ru-Rong Ji*.Chemokines, neuronal-glial interactions, and central processing of neuropathic pain.Pharmacology and Therapeutics.2010, 126(1):56-68
10.Yong-Jing Gao*, Zhen-Zhong Xu, Yen-Chin Liu, Yeong-Ray Wen, Isabelle Decosterd, Ru-Rong Ji*. The c-Jun N-terminal Kinase 1 (JNK1) in spinal astrocytes mediates bilateral mechanical allodynia under a persistent inflammatory pain condition.Pain, 2010,148:309-319
11.Yong-Jing Gao, Ling Zhang, Omar Abdel Samad, Marc R.Suter, Kawasaki Yasuhiko, Zhen-Zhong Xu, Jong-Yeon Park, Anne-Li Lind, Qiufu Ma, Ru-Rong Ji.JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain.Journal of Neuroscience, 2009, 29(13):4096–4108
12.Hong Cao*, Yong-Jing Gao*,Wen-Hua Ren, Ting-Ting Li, Kai-Zheng Duan, Yi-Hui Cui, Xiao-Hua Cao, Zhi-Qi Zhao, Ru-Rong Ji, Yu-Qiu Zhang.Activation of extracellular signal-regulated kinase in the anterior cingulate cortex contributes to the induction and expression of affective pain.Journal of Neuroscience, 2009,29(10):3307–3321 (*Equal contribution)
13.Yong-Jing Gao, Jen-Kun Cheng, Qing Zeng, Zhen-Zhong Xu, Isabelle Decosterd, Xiaoyin Xu, Ru-Rong Ji.Selective inhibition of JNK with a peptide inhibitor attenuates pain hypersensitivity and tumor growth in a mouse skin cancer pain model. Experimental Neurology, 2009, 219:146–155
14.Yong-Jing Gao*, Ru-Rong Ji*.c-Fos or pERK, Which is a better marker for neuronal activation and central sensitization after noxious stimulation and tissue injury? The Open Pain Journal, 2009, 2, 11-17
15.Yong-Jing Gao, Ru-Rong Ji.Activation of JNK pathway in persistent pain.Neuroscience Letter, 2008,6;437(3):180-3
16.Yan-Gang Sun*, Yong-Jing Gao*, Zhong-Qiu Zhao, Bing Huang, Jun Yin, Gregory A Taylor, Zhou-Feng Chen. Involvement of P311 in the affective, but not in the sensory component of pain.Molecular Pain, 2008, 4:23
17.Zhong-Qiu Zhao*, Yong-Jing Gao*, Yan-Gang Sun, Cheng-Shui Zhao, Robert W.Gereau IV, Zhou-Feng Chen.Central serotonergic neurons are differentially required for opioid analgesia, but not for morphine tolerance and morphine reward.PNAS, 2007, 104(36): 14519–14524 (* Equal contribution)
18.Yong-Jing Gao, Wen-Hua Ren, Zhi-Qi Zhao, Yu-Qiu Zhang.Contributions of the anterior cingulate cortex and amygdala to pain- and fear- conditioned place avoidance in rats. Pain, 2004, 110(1-2):343-53
19.Yong-Jing Gao, Yu-Qiu Zhang, Zhi-Qi Zhao.Involvement of spinal neurokinin-1 receptors in the maintenance but not induction of carrageenan-induced thermal hyperalgesia in the rat.Brain Research Bulletin 2003,61(6):587-93
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