南通大学公共卫生学院导师介绍：朱朝勇

　　朱朝勇，1962年5月10日，博士

　　1980.7-1985.7 上海医科大学公共卫生学院 学士学位

　　1985.8-1993.12上海医科大学公共卫生学院 助教和讲师

　　1994.1-1996.4 瑞典Karolinska Instititute 访问学者

　　1996.5-2000.10瑞典Karolinska Instititute 博士学位

　　2001.1-1006.10瑞典Karolinska Instititute 博士后

　　2006.11-2008.1 美国NIH 博士后

　　2008.2-2009.2 美国哈佛大学 博士后

　　研究方向分子毒理学

　　主持在研项目：

　　基因组特异等位基因表达研究砷毒性效应个体差异和机制

　　完成项目：

　　近五年发表论文：

　　1．Zhu C, Johansson M, Permert J and Karlsson A., Enhanced cytotoxicity of nucleoside analogs by overexpression of mitochondrial deoxyguanosine kinase in cancer cell lines, J Biol Chem．1998 Jun 12;273(24):14707-11 (PubMed)

　　2．Zhu C, Johansson M, Permert J and Karlsson A, Phosphorylation of anti-cancer nucleoside analogs by human mitochondrial deoxyguanosine kinase, Biochem Pharmacol．1998 Oct 15;56(8):1035-40．(PubMed)

　　3．Neyts J, Balzarini J, Andrei G, Zhu C, Snoeck R, Zimmerman A, Mertens T, Karlsson A and De Clercq E, Intracellular metabolism of the N7-substituted acyclic nucleoside analog 2-amino-7-(1,3-dihydroxy-2-propoxymethyl)-purine, a potent inhibitor of herpesvirus replication, Mol Pharmacol．1998, Jan;53(1):157-65．(PubMed)

　　4．Hagen K, Zhu C, Melefors O and Hultcrantz R, Susceptibility of cultured rat hepatocytes to oxidative stress by peroxides and iron．The extracellular matrix affects the toxicity of tert-butyl hydroperoxide, Int J Biochem Cell Biol．1999 Mar-Apr;31(3-4):499-508．(PubMed)

　　5．Wettin K, Johansson M, Zheng X, Zhu C and Karlsson A, Cloning of mouse mitochondrial thymidine kinase 2 cDNA, FEBS Lett．1999 Oct 22;460(1):103-6.(PubMed)

　　6．Zhu C, Johansson M and Karlsson A, Differential incorporation of the anti-leukemic nucleoside analog 1-Beta-D-arabinofuranosylcytosine and 9-Beta-D-arabinofuranosylguanine into nuclear and mitochondrial DNA, FEBS Lett．2000 Jun 2;474(2-3):129-32．(PubMed)

　　7．Zhu C, Johansson M and Karlsson A, Incorporation of nucleoside analogs into nuclear or mitochondrial DNA is determined by the intracellular phosphorylation site, J Biol Chem．2000 Sep 1;275(35):26727-31．(PubMed)

　　8．Zhu C, Johansson M and Karlsson A, The subcellular location of nucleoside analog phosphorylation is a determinant of synergistic effects of hydroxyurea, Biochem Biophys Res Commun．2000 Sep 16;276(1):179-82．(PubMed)

　　9．Balzarini J, Zhu C, De Clercq E, Perez-Perez MJ, Chamorro C and Karlsson A, Novel ribofuranosylnucleoside lead compounds for potent and selective inhibitors of mitochondrial thymidine kinase 2, Biochem J．2000 Oct 1;351(Pt1):167-71．(PubMed)

　　10．Balzarinia J, Degreve B, Zhu C, Durini E, Porcu L, De Clercq E, Karlsson A and Manfredini S, 2-O-acyl/alkyl-substituted arabinosylnucleosides as inhibitors of the human mitochondrial thymidine kinase．Biochem Pharmacol．2001 Mar 15;61(6):727-32．(PubMed)

　　11．Curbo S, Zhu C, Johansson M, Balzarini J and Karlsson A, Dual mechanisms of 9-beta-D arabinofuranosylguanine resistance in CEM T-lymphoblast leukemia cells, Biochem Biophys Res Commun． 2001 Jul 6;285(1):40-5．(PubMed)

　　12．Sanda A, Zhu C, Johansson M, Karlsson A, Bystander effects of nucleoside analogs phosphorylated in the cytosol or mitochondria, Biochem Biophys Res Commun．2001 Oct 12;287(5):1163-6．(PubMed)

　　13．Hammarsund M, Corcoran MM, Wilson W, Zhu C, Einhorn S, Sangfelt O, Grander D, Characterization of a novel B-CLL candidate gene--DLEU7—located in the 13q14 tumor suppressor locus．FEBS letters．2004 January 2; 556(1-3):75-80．(PubMed)

　　14．Corcoran MM, Hammarsund M, Zhu C, Lerner M, Kapanadze B, Wilson B,Larsson C, Forsberg L, Ibbotson RE, Einhorn S, Oscier DG, Grander D, Sangfelt O, DLEU2 encodes an antisense RNA for the putative bicistronic RFP2/LEU5 gene in humans and mouse．Genes Chromosomes Cancer．2004 Aug; 40(4):285-97.(PubMed)

　　15．Hammarsund M, Lerner M, Zhu C, Merup M, Jansson M, Gahrton G, Kluin-Nelemans H, Einhorn S, Grander D, Sangfelt O, Corcoran M, Disruption of a novel ectodermal neural cortex 1 antisense gene, ENC-1AS and identification of ENC-1 overexpression in hairy cell leukemia, Hum Mol Genet．2004 Dec 1;13(23):2925-36．(PubMed)

　　16．Eskandarpour M, Kiaii S, Zhu C, Castro J, Sakko AJ, Hansson J, Suppression of oncogenic NRAS by RNA interference induces apoptosis of human melanoma cells, Int J Cancer．2005 May 20; 115(1):65-73．(PubMed)

　　17．Kazi M, Zhu C, Roy J, Paulsson-Berne G, Hamsten A, Swedenborg J, Hedin U, Eriksson P, Difference in matrix-degrading protease expression and activity in thrombus-free and thrombus-covered wall of abdominal aortic aneurysm, Arterioscler Thromb Vasc Biol, 2005, July, 25:1341-1346． (PubMed)

　　18．Hemdahl A-L, Gabrielsen A, Zhu C, Eriksson P, Hedin U, Kastrup J, Thor�n P, Hansson GK, Expression of neutrophil gelatinase associated lipocalin in atherosclerosis and myocardial infarction．Arterioscler Thromb Vasc Biol, 2006 Jan;26(1):136-42．(PubMed)

　　19．Zhu C, Odeberg J, Hamsten A, Eriksson P, Allele-specific MMP-3 transcription under in vivo conditions．Biochem Biophys Res Commun, 2006, Sept 29;348(3):1150-6．(PubMed)

　　20．Bu D-X, Hemdahl A-L, Gabrielsen A, Fuxe J, Zhu C, Eriksson P, Yan Z-Q, Induction of neutrophil gelatinase-associated lipocalin in vascular injury via activation of NF-kB, American Journal of Pathology, 2006, Dec;169(6):2245-53．(PubMed)

　　21．Wågsäter D, Björk H, Zhu C, Björkegren J, Valen G, Hamsten A, Eriksson P ADAMTS-4 and -8 are inflammatory regulated enzymes expressed in macrophage-rich areas of human atherosclerotic plaques．Atherosclerosis．2008 Feb;196(2):514-522．(PubMed)

　　22．Folkesson M, Kazi M, Zhu C, Silveira A, Hemdahl AL, Hamsten A, Hedin U, Swedenborg J, Eriksson P．Presence of NGAL/MMP-9 complexes in human abdominal aortic aneurysms．Thromb Haemost．2007 Aug;98(2):427-433．(PubMed)

　　23．Wågsäter D, Zhu C, Björck HM, Eriksson P．Effects of PDGF-C and PDGF-D on monocyte migration and MMP-2 and MMP-9 expression． Atherosclerosis．2009 Feb;202(2):415-423 (PubMed)

　　24．Li Y, Zhang F, Nagai N, Tang Z, Zhang S, Scotney P, Lennartsson J, Zhu C, Qu Y, Fang C, Hua J, Matsuo O, Fong GH, Ding H, Cao Y, Becker KG, Nash A, Heldin CH, Li X．VEGF-B inhibits apoptosis via VEGFR-1-mediated suppression of the expression of BH3-only protein genes in mice and rats． J Clin Invest．2008 Mar;118(3):913-923.

　　25．Wågsäter D, Zhu C, Björkegren J, Skogsberg J, Eriksson P．MMP-2 and MMP-9 are prominent matrix metalloproteinases during atherosclerosis development in the Ldlr(-/-)Apob(100/100) mouse．Int J Mol Med．2011 Aug;28(2):247-253

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