南通大学药学院导师介绍：张伟

　　张 伟： 男，1957年10月生，药理学教授，药理药剂内科学研究生导师。1990年6月研究生毕业于安徽医科大学心血管药理专业，获医学硕士学位，无党派人士。 现任南通大学医学院药理学系主任；南通大学医药研究所所长；南通大学药学（省重点一级学科培育点）学科带头人；南通大学省优势学科《基础医学》学科（群） 学术带头人（PI）。社会兼职：南通伟康医药研究院院长（独立法人）；南通市生物医药重点实验室常务副主任。学术团体任职：中国药理学会理事；江苏省药理 学会副理事长；江苏省药理教学委员会副主任委员；江苏省新药临床前研究专业委员会副秘书长；南通市药学会药剂药理专业委员会主任委员。从事新药研究与开发 三十多年，先后主持或与企业合作承担各类中西医药研发项目30多项，绝大多数成果转化为生产力，其中有知名品牌“盖天力”、“富硒康”、“安奇”等，有 “九五”科技攻关项目抗高血压新药Moxonidine、抗炎新药Tenoxicam等，技术贸易（技术开发、技术服务、技术转让）达1000多万，近年 来主持国家、省、市厅级研究课题9项，获市厅级科技进步二等奖3项（名第一）, 作为通讯作者（或第一作者）在国内外核心与权威期刊发表专业学术论文40多篇，拥有国家授权发明专利5项。

　　通讯作者（或第一作者）代表作：

　　15．Stat3 pathway correlates with the roles of leptin in mouse liver fibrosis and sterol regulatory element binding protein-1c expression of rat hepatic stellate cells Int J Biochem Cell Biol．． 2013 Mar;45(3):736-44．

　　14．Two novel hydroperoxylated products of 20(S)-protopanaxadiol by Mucor racemosus and their cytotoxic activities against human prostate cancer cells Biotechnol Lett． 2013 Mar;35(3):439-43．

　　13．Proteomic analysis for anti-atherosclerotic effect of tetrahydroxystilbene glucoside in rats． Biomed Pharmacother． 2012 Nov 15．doi:pii: S0753-3322PMID: 23178522

　　12．Microbial transformation of 20(S)-protopanaxadiol by Absidia corymbifera． Cytotoxic activity of the metabolites against human prostate cancer cells．

　　Fitoterapia． 2013 Jan;84:6-10

　　11．The effect of 2, 3, 4', 5-tetrahydroxystilbene-2-0-ß-D glucoside on neointima formation in a rat artery balloon injury model and its possible mechanisms

　　Eur J Pharmacol． 2013 Jan ;698(1-3):370-8

　　10．MiR-17-3p Inhibits Angiogenesis by Downregulating Flk-1 in the Cell Growth Signal Pathway． J Vasc Res． 2012 Dec;50(2):157-166．

　　9．Electrical Field Stimulation Induces Cardiac Fibroblast Proliferation through Calcineurin-NFAT Pathway．

　　Can J Physiol Pharmacol． 2012 Dec;90(12):1611-22．

　　8．SKF83959, an Agonist of the Phosphatidylinositol-Linked D1-Like Receptors, Promotes ERK1/2Activation and Cell Migration in Cultured Rat Astrocytes．

　　PLoS One． 2012 Nov;7(11):e49954．

　　7．2,3,4’,5-Tetrahydroxystilbene-2-0-beta-D-glucoside inhibits proliferation of

　　Vascular smooth muscle cells：involvement of NO/cGMP/PKG pathway．

　　Phytotherapy Research． 2012 Jul;26(7):1068-74

　　6．2,3,4',5-Tetrahydroxystilbene-2-O-beta-D-glucoside Inhibits angiotensin II-induced

　　cardiac fibroblast proliferation through suppression of reactive oxygen species-ERK1/2

　　pathway． Clin Exp Pharmacol Physiol． 2012 May;39(5):429-37．

　　5．2,3,4',5-Tetrahydroxystilbene-2-0-beta-D-glucoside inhibits platelet-derived growth

　　factor-induced proliferation of vascular smooth muscle cells by regulating cell cycle．

　　Clin Exp Pharmacol Physiol． 2011May;38(5):307–313

　　4．Ca2+⁄calmodulin-dependent protein kinase IIδ orchestrates G-protein-coupled

　　receptor and electric field stimulation-induced cardiomyocyte hypertrophy

　　Clin Exp Pharmacol Physiol 2010 Aug;37(8):795–802

　　3．Inhibition of Calcium-Calmodulin-Dependent Kinase II Suppress Cardiac

　　Fibroblast Proliferation and Extracellular Matrix Secretion ．

　　J Cardiovasc Pharmacol 2010 Jan;55(1):96-105

　　2．Effects of 2,3,4’,5-Tetrahydroxystilbene-2-0-β-D-glucoside on vascular endothelial

　　dysfunction in atherogenic-diet rats Planta Medicinal 2009 Sep;75:1209-1214

　　1．2,3,4’,5-TETRAHYDROXYSTILBENE-2-O-β-D-GLUCOSIDE SUPPRESSES MATRIX METALLOPROTEINASE EXPRESSION AND INFLAMMATION IN ATHEROSCLEROTIC

　　RATS． Clin Exp Pharmacol Physiol 2008 Mar;35(3):310-6．

　　*如果发现导师信息存在错误或者偏差，欢迎随时与我们联系，以便进行更新完善。联系方式>>