南京医科大学药学院导师介绍：周学敏

　　周学敏，教授，博导，南京医科大学药学院药学系副主任，江苏省药学综合实验教学示范中心主任，江苏省新药评审委员会委员，江苏省科学研究系列高级职称评审委员，江苏省药物分析学会委员，全国医药院校药学/中药学实验教学中心联席委员会理事等。
　　作为课题负责人研究的各类新药获得国家新药证书和生产批件20余项。其中“国家二类胃动力新药盐酸依托必利的研究与推广” 获得年江苏省科技进步三等奖，第一获奖人;“国家级新药双氯酚酸钾凝胶剂研究” 获得南京市第二届城镇妇女科技创造发明成果二等奖, 第一获奖人;“盐酸伊托必利及制剂的研究和推广”获得南京市科技进步三等奖，第一获奖人。2011南京医科大学“三育人”先进个人奖。

　　研究方向：
　　1．复杂体系微痕量物质靶向捕获新技术与新纳米元件研究及应用
　　2．多基元纳米材料可控自组装电化学传感体系构建及临床应用
　　3．药物质量控制及药代动力学研究

　　近年在研与完成课题情况：
　　[1] 国家自然科学基金项目“基于还原氧化石墨烯和金属纳米粒层层自组装的分子印记电化学传感体系及临床应用”， (81273480,2013.1-2016.12，65万)；课题负责人
　　[2] 国家自然科学基金项目“功能纳米硅胶表面高效率分子印记可控自组装体系构建及应用研究”, (21175070,2012.1-2015.12，60万)；课题负责人
　　[3] 国家自然科学基金项目“基于纳米硅胶表面分子印迹的固相微萃取技术用于雌激素残留分析的研究”(20875048,2009.1-2011.12，33万)；课题负责人
　　[4] 江苏省自然科学基金项目“分子印迹纳米硅胶吸附剂用于农产品残留物的分析研究”,（BK2008439，2008.10-2010.12，10万）；“优秀结题”课题负责人

　　已授权和申请的发明专利:
　　[1] 周学敏，马静等. “一种雌激素特异性纳米硅胶表面分子印迹材料的制备方法”（NO：200910184042.4已授权）
　　[2] 周学敏，丁美娟等. “用于检测PDE-5抑制剂的磁性分子印记聚合物的制备方法”（NO：201010601460.1已授权）
　　[3] 周学敏，吴晓丽等. “一种雌激素替代模板分子印迹固相微萃取萃取头的制备方法”（NO：201110041332.0已授权）
　　[4] 周学敏，姜慧君，李芸等. “一种17β-雌二醇分子印记膜电化学传感器的制备方法”（NO：201110194327.3）
　　[5] 周学敏，汪洋等.“哑铃状分子印迹搅拌棒的制备方法”（NO：201210444491.X）
　　[6]周学敏，姜慧君，韩青等.“一种西地那非分子印记膜电化学传感器的制备方法”（NO：201210225721.3）
　　[7] 周学敏, 姜慧君，文婷婷等. “还原态石墨烯与铂纳米粒子复合材料修饰雌二醇分子印记膜电化学传感器的制备方法”( NO: 201110446939.7 )
　　[8] 周学敏，王舒等.“一种雌激素纳米硅胶表面树枝状分子印记聚合物磁珠的制备方法” (NO: 201110446939.7)
　　[9] 周学敏，王若禹等.“格列本脲磁性纳米硅胶表面聚酰胺-胺树枝状分子印记聚合物的制备方法”（NO: 201110426440.X）
　　[10]周学敏,姜慧君，薛诚等.“一种用于检测多巴胺的金纳米粒掺杂的MES的制备方法” (NO:201310023869.3)

　　发表的主要SCI研究论文：
　　[1] Yun Li, Tingting Wen, Cheng Xue, Qing Han, Yang Wang, Junli Hong, Xuemin Zhou（通讯作者）, Huijun Jiang.RGO LBL modified biomimetic electrochemical sensor for detection of Sildenafil in herbal sexual health products. Biosensors and Bioelectronics. 2013,42:287-292
　　[2] Cheng Xue, Qing Han, Yang Wang, Jinhua Wu, Tingting Wen, Ruoyu Wang, Junli Hong, Xuemin Zhou（通讯作者）, Huijun Jiang*. Amperometric detection of dopamine in human serum by electrochemical sensor based on gold nanoparticles doped molecularly imprinted polymers.Biosensors and Bioelectronics. 2013.49:199-203
　　[3] Jing Ma, Lihua Yuan, Meijuan Ding, Shu Wang, Feng Ren, Jun Zhang, Shuhu Du, Fei Li, Xuemin Zhou（通讯作者）. The study of core-shell molecularly imprinted polymers of 17β-estradiol on the surface of silica nanoparticles.Biosensors and Bioelectronics,2011,26:2791-2795
　　[4] Lihua Yuan, Jun Zhang, Ping Zhou, Jiaxing Chen, Ruoyu Wang, Tingting Wen, Yun Li, Xuemin Zhou（通讯作者）, Huijun Jiang.Electrochemical sensor based on molecularly imprinted membranes at platinum nanoparticles-modified electrode for determination of 17β-estradiol. Biosensors and Bioelectronics.2011,29:29-33
　　[5] Yun Li,Mei-juan Ding,Shu Wang, Ruo-yu Wang, Xiao-li Wu, Ting-ting Wen, Li-hua Yuan, Peng Dai, Yu-hui Lin, and Xue-min Zhou（通讯作者）.Preparation of Imprinted Polymers at Surface of Magnetic Nanoparticles for the Selective Extraction of Tadalafil from Medicines.ACS Appl. Mater. Interfaces. 2011,3(9):3308-3315
　　[6] Jing Ma, LiHua Yuan, MeiJuan Ding, Jun Zhang, Qing Zhang, QunWei Xu, XueMin Zhou（通讯作者）. Determination of itopride hydrochloride in human plasma by RP-HPLC with fluorescence detection and its use in bioequivalence study.Pharmacological Research, 2009,59(3):189-193
　　[7] Shu Wang, Yun Li, Xiaoli Wu, Meijuan Ding, Lihua Yuan, Ruoyu Wang, Tingting Wen,Jun Zhang, Lina Chen, Xuemin Zhou（通讯作者）, Fei Li. Construction of uniformly sized pseudo template imprinted polymers coupled with HPLC-UV for the selective extraction and determination of trace estrogens in chicken tissue.Journal of Hazardous Materials,2011,186(2-3):1513-1519
　　[8]Meijuan Ding, Xiaoli Wu, Lihua Yuan, Shu Wang, Yun Li, Ruoyu Wang, Tingting Wen, Shuhu Du, XueminZhou（通讯作者）.Syntheses of Core-shell Magnetic Molecularly Imprinted Polymers and Detection of Sildenafil and Vardenafil in Herbal Dietary Supplements. Journal of Hazardous Materials. 2011,191(1-3):177-183
　　[9] Lihua Yuan, Jing Ma, Meijuan Ding, Shu Wang, Xiaoli Wu, Yun Li, Kunfang Ma, Xuemin Zhou（通讯作者）, Fei Li.Preparation of estriol-molecularly imprinted silica nanoparticles for determining estrogens in milk tablets.Food Chemistry. 2012,131(3):1063-1068
　　[10]Shu Wang, Yun Li, Xiaoli Wu, Meijuan Ding, Jinhui Xu, Ruoyu Wang, Wenyu Huang, Ping Zhou, Kunfang Ma,Xuemin Zhou（通讯作者）, Shuhu Du. Self-assembly molecularly imprinted polymers of E2 on the surface of magnetic nanoparticles for selective separation and detectionof estrogenic hormones in feeds.Journal of Chromatography B.2011, 879(25):2595-2600
　　[11] Shu Wang, Ruoyu Wang, Xiaoli Wu, Yang Wang, Cheng Xue, Jinhua Wu, Junli Hong, Jie Liu, Xuemin Zhou（通讯作者）.Magnetic molecularly imprinted nanoparticles based on dendronized modification for determination of estrogens in plasma samples.Journal of Chromatography B.2012,905(15): 105-11
　　[12] Ruoyu Wang, Yang Wang, Cheng Xue, Tingting Wen, Jinhua Wu, Junli Hong, Xuemin Zhou（通讯作者）. Selective HPLC separation and enrichment of glibenclamide in health foods using surface molecularly imprinted polymers prepared via dendritic-grafting of magnetic nanoparticles. J. Sep. Sci. 2013, 36:1015–1021
　　[13] Lihua Yuan,Meijuan Ding, Jing Ma,Jinhui Xu,Xiaoli Wu, Jing Feng,Fei Shen,Xuemin Zhou（通讯作者）. Determination of finasteride in human plasma by liquid chromatography electrospray ionization tandem mass spectrometry with flow rate gradient.Eur J Drug Metab Pharmacokinet,2011, 35(3-4):137-146
　　[14]Yun Li,MeiJuan Ding,Jing Ma,Shu Wang,XiaoLi Wu,Hui-Juan Xu,ZhengYu Lu,JianJun Zou,HongWei Fan,XueMin Zhou（通讯作者）.Quantification of pantoprazole in human plasma using LC-MS/MS for pharmacokinetics and bioequivalence study.Eur J Drug Metab Pharmacokinet . 2011,35(3):147-155
　　[15] Jing Ma, Jing Cao, Meijuan Ding, Lihua Yuan, Meijuan Zhai, Jun Zhang, Qing Zhang,Fei Li, Xuemin Zhou（通讯作者）.Separation of Fudosteine on an Achiral C18 Column by HPLC with Chiral Ligand-Exchange Selectors as Mobile Phase Additives.Acta Chromatographica, 2008,20(4):585-594
　　[16]Zhou Xue-Min, Liu Jie, Gao Juan, Yao Quan-Sheng, Wang Wen-Yan. Determinnation of azithromycin in human plasma by LC-MS-MS and its pharmacokinetics. Pharmazie, 2007,62(4):255-257
　　[17] Tingting Wen, Cheng Xue, Yun Li, Yang Wang, Ruoyu Wang, Junli Hong, Xuemin Zhou（通讯作者）and Huijun Jiang.Reduced graphene oxide-platinum nanoparticles composites based imprinting sensor for sensitively electrochemical analysis of 17β-estradiol.Journal of Electroanalytical Chemistry. 2012,682:121-127
　　[18] Xiaoli Wu, Jie Liu, Jinhua Wu, Yang Wang, Cheng Xue, Ruoyu Wang, Junli Hong, Xuemin Zhou（通讯作者）. Molecular imprinting-based micro-stir bar sorptive extraction for specific analysis of Glibenclamide in herbal dietary supplements. J. Sep. Sci. 2012,35(24):3593-3599
　　[19] Xiaoli Wu, Jinhua Wu, Shu Wang, Ruoyu Wang, Yun Li, Tingting Wen, Dandan Zhong, Junli Hong, Qin Hu, Xuemin Zhoua（通讯作者）. An analytical method for estrogens in milk powder by pseudo template imprinted polymers coated fiber coupled with HPLC.Analytical Method. 2012,4 (10): 3300-3306
　　[20] Shi Liu, Jun Yan, Guangwu He, Dandan Zhong, Jiaxing Chen, Liying Shi, Xuemin Zhou, Huijun Jiang. Layer-by-layer assembled multilayer films of reduced graphene oxide/gold nanoparticles for the electrochemical detection of dopamine. Journal of Electroanalytical Chemistry. 2012,672:40-44
　　[21] Na Sheng,Fangdi Wei,Wen Zhan,Zheng Cai,Shuhu Du,Xuemin Zhou,Fei Li,Qin Hu. Dummy molecularly imprinted polymers as the coating of stir bar for sorptive extraction of bisphenol A in tap water. J. Sep. Sci. 2012,35:707-712
　　[22] Wen Zhan,Fangdi Wei,Guanhong Xu,Zheng Cai,Shuhu Du,Xuemin Zhou,Fei Li,Qin Hu. Highly selective stir bar coated with dummy molecularly imprinted polymers for trace analysis of bisphenol A in milk.J. Sep. Sci. 2012,35:1036-1043

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