南京医科大学基础医学院导师介绍：徐涌

　　徐涌，博士，教授，博士生导师
　　研究方向：1.心血管疾病中的转录调控；2.依赖于抗原呈递的免疫激活与耐受的调控
　　地址：南京市汉中路140号病理生理学系
　　邮编：210029
　　电话：************

　　个人简介：
　　B.S., Biology, Peking University College of Life Sciences
　　Ph.D., Biochemistry, Cell and Molecular Biology, Boston University School of Medicine

　　代表论文:
　　Xu Y, Wang L, Buttice G, Sengupta PK, Smith BD, Major histocompatibility class II transactivator (CIITA) mediates repression of collagen (COL1A2) transcription by interferon gamma (IFN-gamma). J Biol Chem, 2004 Oct 1;279(40):41319-32. Epub 2004 Jul 6.
　　Xu Y, Harton J, Smith BD, CIITA mediates interferon-gamma repression of collagen transcription through phosphorylation dependent interactions with co-repressor molecules. J Biol Chem, 2008 Jan 18;283(3): 1243-1256. Epub 2007 Nov 8.
　　Kong XC, Fang MM, Li P, Fang F, Xu Y, HDAC2 deacetylates CIITA and suppresses its activity in macrophages and smooth muscle cells. J Mol Cell Cardiol, 2009 Mar; 46(3): 292-299. Epub 2008 Nov 7 (highlighted article of the issue with complementary editorial)
　　Fang MM, Kong XC, Fang F, Li P, Wu XY, Bai H, Qi XH, Chen Q, Xu Y, RFXB and its splice variant RFXBSV mediate the antagonism between IFN-g and TGF-b on COL1A2 transcription in vascular smooth muscle cells. Nucleic Acids Research, 2009 Jul; 37(13):4393-406. Epub 2009 May 22
　　Wu XY, Kong XC, Luchsinger L, Smith BD, Xu Y, Regulating the activity of class II transactivator by post-translational modifications: Exploring the possibilities. Mol Cell Biol, in press. Epub 2009 August 31,2009; 29(21): 5639-44.
　　Fang F, Yang YY, Yuan ZB, Gao YQ, Zhou JL, Chen Q, Xu Y: Myocardin related transcription factor A (MRTF-A) mediates oxLDL induced endothelial injury. Circ Res, 2011 Apr 1;108(7): 797-807.

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