南京医科大学基础医学院导师介绍：周洪

　　周洪，男，博士，现为南京医科大学微生物免疫学系教授，江苏省特聘教授，生殖医学国家重点实验室PI，江苏省免疫学会理事，中国免疫学会青年工作委 员会委员，J．Immunol.，J．Neuroimmunol.等期刊审稿人。1996年始在上海交通大学医学院从事免疫调节和移植免疫学研究，自2002年开始在北美多个研究机构一直从事 炎症和细胞招募相关的科研工作，曾获得加拿大健康研究所奖学金。工作主要揭示了小胶质细胞在脑部炎症状态下激活并介导免疫细胞招募和内皮细胞在系统性炎症 中通过TLR4直接识别病原的具体机制。2010年11月回国工作，现主持国家自然科学基金，江苏省自然科学基金，江苏省教育厅特聘教授研究基金，国家重 点实验室开放课题等多项科研项目。

　　发表论文：
　　1．Moriarty, T.J., Shi M, Lin YP, Ebady R, Zhou H, Benoit V., Wu J., Hardy P.O., Salman A．D., Kubes P., Skare J.T., Leong J.M., and Chaconas G．Vascular binding of a pathogen under shear force through mechanistically distinct sequential interactions with host macromolecules．Mol Microbiol．2012 Oct 24．[Epub ahead of print]
　　2．Chi J, Hu WX, Gu B, Zhang C, Peng GY, Zhou F, Chen Y, Zhang GF, Guo YD, Guo D, Qin J, Wang JF, Li LL, Wang F, Liu G, Xie F, Feng DJ, Zhou H, Huang X, Lu S, Yao K Human herpesvirus 6 latent infection in glioma patients．J Infect Dis．2012 Sep 7．[Epub ahead of print]
　　3．Langer HF, Choi EY, Zhou H, Schleicher R, Chung KJ, Tang Z, G?bel K, Bdeir K, Chatzigeorgiou A, Wong C, Bhatia S, Kruhlak MJ, Rose JW, Burns JB, Hill KE, Qu H, Zhang Y, Lehrmann E, Becker KG, Wang Y, Simon DI, Nieswandt B, Lambris JD, Li X, Meuth SG, Kubes P, Chavakis T．Platelets Contribute to the Pathogenesis of Experimental Autoimmune Encephalomyelitis．Circ Res．2012 Mar 28．[Epub ahead of print]
　　4．Cao J, Song W, Gu B, Mei YL, Tang JP, Meng L, Yang CQ, Wang HJ, Zhou H Correlation between carbapenem consumption and antimicrobial resistance rates of Acinetobacter baumannii in a university affiliated hospital．J Clin Pharmacol．2012 Feb 2．[Epub ahead of print]
　　5．Shi M, Li S, Zheng C, Jones GJ, Zhou H, Kubes P, Mody CH Real-time imaging of trapping and ureasedependent transmigration of Cryptococcus neoformans in mouse brain．J Clin．Invest．2010, 120: 1683-1693.
　　6．Lee WY, Moriarty TJ, Wong CH, Zhou H, Chaconas G, Strieter R, Kubes P An intravascular immune response to Borrelia burgdorferi involves Kupffer cells and iNKT cells．Nat Immunol．2010, 11:295-302.
　　7．Zhou H, Andonegui G, Wong CH, Kubes P Role of endothelial TLR4 for neutrophil recruitment into central nervous system microvessels in systemic inflammation．J Immunol．2009, 183: 5244-5250.
　　8．Andonegui G*, Zhou H*, Bullard D, Kelly M, MacDonald B, Mullaly S, Long E, Robbins S, Kubes P Mice that exclusively express TLR4 on endothelial cells can efficiently clear a lethal systemic Gram-negative bacterial infection．J Clin Invest．2009, 119: 1921-1930．Research highlighted in Nat Rev Immunol．Aug．2009, 9:532
　　* Co-first authors equally contributed to the work
　　9．Menezes G, Lee WY, Zhou H, Waterhouse C, Cara D, Kubes P Selective down-regulation of neutrophil Mac-1 in endotoxemic hepatic microcirculation via IL-10．J Immunol．2009, 183: 7557–7568.
　　10．Audoy JR, Soulet D, Zhou H, Kubes P, Vallières L Rod-shaped monocytes patrol the brain vasculature and give rise to perivascular macrophages under the influence of pro- inflammatory cytokines and angiopoietin-2．J Neurosci．2008, 28: 10187-10199
　　11．Zhou H, Lapointe BM, Clark SR, Kubes P．A requirement for microglial TLR4 in leukocyte recruitment into brain in response to LPS．J Immunol．2006, 177:8103-10.
　　12．Zhou H, Jiao Z, Pan J, Hong J, Tao J, Li N, Zhou Y, Zhang J, Zhou GY．Immune suppression via IL-4/IL-10-secreting T cells: A nontoxic property of anti-HIV agent trichosanthin．Clin Immunol．2007, 122: 312-322.
　　13．Cao Y, Zhou H, Tao J, Zheng Z, Li N, Shen B, Shih TS, Hong J, Zhang J, Zhou GY．Keratinocytes induce local tolerance to skin graft by activating IL-10-secreting T cells in the context of costimulation molecule B7-H1．Transplantation 2003, 75: 1390-6.

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