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南京医科大学基础医学院导师介绍:霍然


  霍然,博士,女,1978年1月出生,现任南京医科大学组织胚胎学系副教授,硕士生导师。2002年毕业于东南大学与 南京医科大学联合培养生物医学工程及临床医学双学位专业;2006年毕业于南京医科大学人体解剖与组织胚胎学系,获博士学位。近年来主要从事配子发生、成 熟及早期胚胎发育相关的蛋白质组学及蛋白功能研究。主持完成了国家973计划课题及国家自然科学基金青年科学基金项目各一项,在本领域专业期刊上发表 SCI论文20余篇。

  社会兼职:
  中科院动物所兼职副研究员,中国解剖学会会员

  获奖:
  2010年“ 精子发生相关蛋白质组学研究”获教育部2010年度高等学校科学研究优秀成果奖(自然科学奖)二等奖 (排名第三)
  2009年被却确立为江苏省第三期“333工程”第3层次培养对象

  代表性论文:
  Guo X, Zhao C, Wang F, Zhu Y, Cui Y, Zhou Z, Huo R&, Sha J. Investigation of human testis protein heterogeneity using 2-dimensional electrophoresis. J Androl. 2010 Jul-Aug;31(4):419-29. &corresponding author
  Ma M, Zhou L, Guo X, Lv Z, Yu Y, Ding C, Zhang P, Bi Y, Xie J, Wang L, Lin M, Zhou Z, Huo R#, Sha J, Zhou Q#,. Decreased cofilin1 expression is important for compaction during early mouse embryo development. Biochim Biophys Acta. 2009 Dec;1793(12):1804-10. #co-corresponding author
  Zhang P, Ni X, Guo Y, Guo X, Wang Y, Zhou Z, Huo R&, Sha J. Proteomic-based identification of maternal proteins in mature mouse oocytes. BMC Genomics. 2009 Aug 3;10:348. &corresponding author
  Yu Y, Wu JD, Fan Y, Lv Z, Guo XJ, Zhao C, Zhou R, Zhang Z, Wang FQ, Xiao M, Chen L, Zhu H, Chan W, Lin M, Liu JY, Zhou ZM, Wang L, Huo R#, Zhou Q#, Sha JH. Evaluation of blastomere biopsy using mouse model indicates the potential high-risk of neurodegenerative disorders in the offspring. Mol Cell Proteomics. 2009 Jul;8(7):1490-500.. #co-corresponding author
  Ma M, Guo X, Wang F, Zhao C, Liu Z, Shi Z, Wang Y, Zhang P, Zhang K, Wang N, Lin M, Zhou Z, Liu J, Li Q, Wang L, Huo R#, Sha J, Zhou Q#. Protein expression profile of the mouse metaphase-II oocyte. J Proteome Res. 2008 Nov;7(11):4821-30. #co-corresponding author
  Huo R, He Y, Zhao C, Guo XJ, Lin M, Sha JH. Identification of human spermatogenesis-related proteins by comparative proteomic analysis: a preliminary study. Fertil Steril. 2008 Oct;90(4):1109-18.
  Zhao C*, Huo R*, Wang FQ, Lin M, Zhou ZM, Sha JH. Identification of several proteins involved in regulation of sperm motility by proteomic analysis. Fertil Steril. 2007 Feb;87(2):436-8. *co-author
  Lu Y*, Huo R*, Yuan Y, Li J, Shi Q, Sha J. Human testicular protein NYD-SP16 is involved in sperm capacitation and the acrosome reaction. Fertil Steril. 2006 Oct;86(4 Suppl):1228-34. *co-author
  Huo R, Zhu H, Lu L, Ying L, Xu M, Xu Z, Li J, Zhou Z, Sha J. Molecular cloning, identification and characteristics of a novel isoform of carbamyl phosphate synthetase I in human testis. J Biochem Mol Biol. 2005 Jan 31;38(1):28-33.
  Huo R*, Zhu YF*, Ma X, Lin M, Zhou ZM, Sha JH. Differential expression of glucose-regulated protein 78 during spermatogenesis. Cell Tissue Res. 2004 Jun;316(3):359-67. *co-author

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