南京医科大学基础医学院导师介绍：苗登顺

　　苗登顺，博士，特聘教授，博士生导师，骨与干细胞研究中心主任。
　　研究方向：内分泌和骨骼生物学、骨与矿物质研究
　　地址：南京市汉中路140号骨与干细胞研究中心
　　邮编：210029
　　电话：************
　　E-mail：dsmiao@njmu.edu.cn

　　个人简介：
　　苗登顺 男，1954年生，博士、特聘教授、博士生导师，Journal of Bone and Mineral Research、Endocrinology、British Journal of Cancer、Biotechnology Progress和Toxicology and Applied Pharmacology杂志审稿人，南京医科大学解剖学系学术带头人，骨与干细胞研究中心主任，加拿大McGill大学医学系兼职教授。博士毕业于英国 Sheffield大学,博士后训练在加拿大的 McGill大学完成，师从David Goltzman教授(加拿大皇家院士)。2002至2005年在加拿大McGill大学担任助理教授。2005年5月归国。在过去的5年中，发表SCI 收录的英文全文著作32篇，累计影响因子超过200，引用近500次；SCI收录的英文会议摘要32篇，参编英文论著两部。苗登顺教授利用不同的甲状旁腺 素，甲状旁腺素相关肽及25-1α-羟化酶等基因敲除动物模型进行骨与干细胞生物学方面的研究。在相关领域的研究中，其研究水平目前处于国际领先地位。

　　获奖情况：
　　1994　　江苏省普通高校优秀青年骨干教师
　　1995．1-1996．1 英国皇家协会信托奖学金
　　1996．1-1999．1 英国sheffield大学奖学金
　　1999．7-2002．6 加拿大国立卫生研究院职业奖学金
　　2001．10　　美国骨与矿物质研究青年学者奖
　　2002-2005　　蒙特利尔总医院175周年奖学金

　　承担项目和在研资金情况
　　2009-2012 国家自然科学基金重点项目160万
　　2006-2009 国家自然科学基金面上项目30万
　　2007-2009 江苏省卫生厅基金项目8
　　2006-2008 江苏省自然科学基金重点项目30
　　2008-2010 教育部博士点基金6
　　2009-2012 江苏省自然科学基金项目10
　　2005．5: 南医大人才引进启动资金200万元
　　2005-2008 国家重点学科培育点200万元
　　2002-2005 钙调激素在促进骨形成中的作用机制。蒙特利尔总医院科研基金。17．5万加币。
　　2002-2004 维生素D和PTH在调节骨代谢和钙离子平衡中的相互作用。加拿大国立卫生研究院。11．5万加币．

　　论文发表：
　　1．Cao, G．, Gu, Z．, Ren, Y．, Shu, L．, Tao, C．, Karaplis, A．, Goltzman, D．, and Miao, D． (Corresponding Author) 2009． Parathyroid hormone contributes to regulating milk calcium content and modulates neonatal bone formation cooperatively with calcium． Endocrinology 150:561-569．
　　2．?Zhang, Z．L．, Tong, J．, Lu, R．N．, Scutt, A．M．, Goltzman, D．, and Miao, D．S． (Corresponding Author) 2009． Therapeutic potential of non-adherent BM-derived mesenchymal stem cells in tissue regeneration． Bone Marrow Transplant 43:69-81．
　　3．Bai, X．, Dinghong, Q．, Miao, D．, Goltzman, D．, and Karaplis, A．C． 2009． Klotho ablation converts the biochemical and skeletal alterations in FGF23 (R176Q) transgenic mice to a Klotho-deficient phenotype． Am J Physiol Endocrinol Metab 296:E79-88．
　　4．Miao, D．, Su, H．, He, B．, Gao, J．, Xia, Q．, Zhu, M．, Gu, Z．, Goltzman, D．, and Karaplis, A．C． 2008． Severe growth retardation and early lethality in mice lacking the nuclear localization sequence and C-terminus of PTH-related protein． Proc Natl Acad Sci U S A 105:20309-20314．
　　5．Zhou, C．, Lu, F．, Cao, K．, Xu, D．, Goltzman, D．, and Miao, D． (Corresponding Author) 2008． Calcium-independent and 1,25(OH)2D3-dependent regulation of the renin-angiotensin system in 1alpha-hydroxylase knockout mice． Kidney Int 74:170-179．
　　6．Samadfam, R．, Xia, Q．, Miao, D．, Hendy, G．N．, and Goltzman, D． 2008． Exogenous PTH and endogenous 1,25-dihydroxyvitamin D are complementary in inducing an anabolic effect on bone． J Bone Miner Res 23:1257-1266．
　　7． Liu Z, Miao D, Xia Q, Hermo L, Wing SS 2007 Regulated expression of the ubiquitin protein ligase, E3(Histone)/LASU1/Mule/ARF-BP1/HUWE1, during spermatogenesis． Dev Dyn 236:2889-2898
　　8． Kalantari F, Miao D, Emadali A, Tzimas GN, Goltzman D, Vali H, Chevet E,Auguste P 2007 Cellular and molecular mechanisms of abnormal calcification following ischemia-reperfusion injury in human liver transplantation． Mod Pathol 20:357-366
　　9．Gao J, Tiwari-Pandey R, Samadfam R, Yang Y, Miao D, Karaplis AC, Sairam MR, Goltzman D 2007 Altered ovarian function affects skeletal homeostasis independent of the action of follicle-stimulating hormone． Endocrinology 148:2613-2621
　　10．Bai X, Miao D, Goltzman D, Karaplis AC 2007 Early lethality in Hyp mice with targeted deletion of Pth gene． Endocrinology 148:4974-4983
　　11．Xue Y, Karaplis AC, Hendy GN, Goltzman D, Miao D (Corresponding Author) 2006 Exogenous 1,25-dihydroxyvitamin D3 exerts a skeletal anabolic effect and improves mineral ion homeostasis in mice that are homozygous for both the 1alpha-hydroxylase and parathyroid hormone null alleles． Endocrinology 147:4801-4810
　　12．Xue Y, Zhang Z, Karaplis AC, Hendy GN, Goltzman D, Miao D (Corresponding Author) 2005 Exogenous PTH-related protein and PTH improve mineral and skeletal status in 25-hydroxyvitamin D-1alpha-hydroxylase and PTH double knockout mice． J Bone Miner Res 20:1766-1777
　　13．Xue Y, Karaplis AC, Hendy GN, Goltzman D, Miao D (Corresponding Author) 2005 Genetic models show that parathyroid hormone and 1,25-dihydroxyvitamin D3 play distinct and synergistic roles in postnatal mineral ion homeostasis and skeletal development． Hum Mol Genet 14:1515-1528
　　14．Miao D, He B, Jiang Y, Kobayashi T, Soroceanu MA, Zhao J, Su H, Tong X, Amizuka N, Gupta A, Genant HK, Kronenberg HM, Goltzman D, Karaplis AC 2005 Osteoblast-derived PTHrP is a potent endogenous bone anabolic agent that modifies the therapeutic efficacy of administered PTH 1-34． J Clin Invest 115:2402-2411
　　15．Cao MY, Lee Y, Feng N, Li H, Du C, Miao D, Li J, Lee V, Jin H, Wang M, Gu X, Wright JA, Young AH 2005 NK cell activation and tumor infiltration are involved in the antitumor mechanism of Virulizin． Cancer Immunol Immunother 54:229-242
　　16．Sun LQ, Lee DW, Zhang Q, Xiao W, Raabe EH, Meeker A, Miao D, Huso DL, Arceci RJ 2004 Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG． Genes Dev 18:1035-1046
　　17．Soroceanu MA, Miao D, Bai XY, Su H, Goltzman D, Karaplis AC 2004 Rosiglitazone impacts negatively on bone by promoting osteoblast/osteocyte apoptosis． J Endocrinol 183:203-216
　　18．Shin HI, Divieti P, Sims NA, Kobayashi T, Miao D, Karaplis AC, Baron R, Bringhurst R, Kronenberg HM 2004 Gp130-mediated signaling is necessary for normal osteoblastic function in vivo and in vitro． Endocrinology 145:1376-1385
　　19．Panda DK, Miao D (Co-first author), Bolivar I, Li J, Huo R, Hendy GN, Goltzman D 2004 Inactivation of the 25-hydroxyvitamin D 1alpha-hydroxylase and vitamin D receptor demonstrates independent and interdependent effects of calcium and vitamin D on skeletal and mineral homeostasis． J Biol Chem 279:16754-16766
　　20．Miao D, Murant S, Scutt N, Genever P, Scutt A 2004 Megakaryocyte-bone marrow stromal cell aggregates demonstrate increased colony formation and alkaline phosphatase expression in vitro． Tissue Eng 10:807-817
　　21．Miao D, Liu H, Plut P, Niu M, Huo R, Goltzman D, Henderson JE 2004 Impaired endochondral bone development and osteopenia in Gli2-deficient mice． Exp Cell Res 294:210-222
　　22．Miao D, Li J, Xue Y, Su H, Karaplis AC, Goltzman D 2004 Parathyroid hormone-related peptide is required for increased trabecular bone volume in parathyroid hormone-null mice． Endocrinology 145:3554-3562
　　23．Miao D, He B, Lanske B, Bai XY, Tong XK, Hendy GN, Goltzman D, Karaplis AC 2004 Skeletal abnormalities in Pth-null mice are influenced by dietary calcium． Endocrinology 145:2046-2053
　　24．Miao D, Bai X, Panda DK, Karaplis AC, Goltzman D, McKee MD 2004 Cartilage abnormalities are associated with abnormal Phex expression and with altered matrix protein and MMP-9 localization in Hyp mice． Bone 34:638-647
　　25．Goltzman D, Miao D, Panda DK, Hendy GN 2004 Effects of calcium and of the Vitamin D system on skeletal and calcium homeostasis: lessons from genetic models． J Steroid Biochem Mol Biol 89-90:485-489
　　26．Bai X, Miao D, Li J, Goltzman D, Karaplis AC 2004 Transgenic mice overexpressing human fibroblast growth factor 23 (R176Q) delineate a putative role for parathyroid hormone in renal phosphate wasting disorders． Endocrinology 145:5269-5279
　　27．Zhou ZF, Peretz Y, Chang Y, Miao DS, Li X, Prud'homme GJ 2003 Intramuscular gene transfer of soluble B7．1/IgG(1) fusion cDNA induces potent antitumor immunity as an adjuvant for DNA vaccination． Cancer Gene Ther 10:491-499
　　28．Yu R, Yakar S, Liu YL, Lu Y, LeRoith D, Miao D, Liu JL 2003 Liver-specific IGF-I gene deficient mice exhibit accelerated diabetes in response to streptozotocin, associated with early onset of insulin resistance． Mol Cell Endocrinol 204:31-42
　　29．Thomas G, Moffatt P, Salois P, Gaumond MH, Gingras R, Godin E, Miao D, Goltzman D, Lanctot C 2003 Osteocrin, a novel bone-specific secreted protein that modulates the osteoblast phenotype． J Biol Chem 278:50563-50571
　　30．Pizzi H, Gladu J, Carpio L, Miao D, Goltzman D, Rabbani SA 2003 Androgen regulation of parathyroid hormone-related peptide production in human prostate cancer cells． Endocrinology 144:858-867
　　31．Chan GK, Miao D, Deckelbaum R, Bolivar I, Karaplis A, Goltzman D 2003 Parathyroid hormone-related peptide interacts with bone morphogenetic protein 2 to increase osteoblastogenesis and decrease adipogenesis in pluripotent C3H10T 1/2 mesenchymal cells． Endocrinology 144:5511-5520
　　32．Bai XY, Miao D (Co-first author), Goltzman D, Karaplis AC 2003 The autosomal dominant hypophosphatemic rickets R176Q mutation in fibroblast growth factor 23 resists proteolytic cleavage and enhances in vivo biological potency． J Biol Chem 278:9843-9849
　　33．Miao D, Scutt A 2002 Histochemical localization of alkaline phosphatase activity in decalcified bone and cartilage． J Histochem Cytochem 50:333-340
　　34．Miao D, Scutt A 2002 Recruitment, augmentation and apoptosis of rat osteoclasts in 1,25-(OH)2D3 response to short-term treatment with 1,25-dihydroxyvitamin D3 in vivo． BMC Musculoskelet Disord 3:16
　　35．Miao D, He B, Karaplis AC, Goltzman D 2002 Parathyroid hormone is essential for normal fetal bone formation． J Clin Invest 109:1173-1182
　　36．Deckelbaum RA, Chan G, Miao D, Goltzman D, Karaplis AC 2002 Ihh enhances differentiation of CFK-2 chondrocytic cells and antagonizes PTHrP-mediated activation of PKA． J Cell Sci 115:3015-3025
　　37．Bai X, Miao D (Co-first author), Panda D, Grady S, McKee MD, Goltzman D, Karaplis AC 2002 Partial rescue of the Hyp phenotype by osteoblast-targeted PHEX (phosphate-regulating gene with homologies to endopeptidases on the X chromosome) expression． Mol Endocrinol 16:2913-2925
　　38．Panda DK, Miao D (Co-first author), Tremblay ML, Sirois J, Farookhi R, Hendy GN, Goltzman D 2001 Targeted ablation of the 25-hydroxyvitamin D 1alpha -hydroxylase enzyme: evidence for skeletal, reproductive, and immune dysfunction． Proc Natl Acad Sci U S A 98:7498-7503
　　39．Panda DK, Miao D, Lefebvre V, Hendy GN, Goltzman D 2001 The transcription factor SOX9 regulates cell cycle and differentiation genes in chondrocytic CFK2 cells． J Biol Chem 276:41229-41236
　　40．Miao D, Tong XK, Chan GK, Panda D, McPherson PS, Goltzman D 2001 Parathyroid hormone-related peptide stimulates osteogenic cell proliferation through protein kinase C activation of the Ras/mitogen-activated protein kinase signaling pathway． J Biol Chem 276:32204-32213
　　41．Miao D, Bai X, Panda D, McKee M, Karaplis A, Goltzman D 2001 Osteomalacia in hyp mice is associated with abnormal phex expression and with altered bone matrix protein expression and deposition． Endocrinology 142:926-939
　　42．He B, Deckelbaum RA, Miao D, Lipman ML, Pollak M, Goltzman D, Karaplis AC 2001 Tissue-specific targeting of the pthrp gene: the generation of mice with floxed alleles． Endocrinology 142:2070-2077
　　43．Erben RG, Scutt AM, Miao D, Kollenkirchen U, Haberey M 1997 Short-term treatment of rats with high dose 1,25-dihydroxyvitamin D3 stimulates bone formation and increases the number of osteoblast precursor cells in bone marrow． Endocrinology 138:4629-4635
　　44．Miao D, Skibinski G, James K 1996 The effects of human seminal plasma and PGE2 on mitogen induced proliferation and cytokine production of human splenic lymphocytes and peripheral blood mononuclear cells． J Reprod Immunol 30:97-114

　　参编著作：
　　1．Miao D, He B, Lanske B, Bai XY, Tong XK, Hendy GN, Goltzman D and?? Karaplis AC． Skeletal and reproductive abnormalities in pth-null mice． In: Molecular Biology of the Parathyroid． Naveh-Many, Tally (Ed．)． 2005:179-197．
　　2． D． Goltzman, D． Miao． Alkaline phosphatase． M． L, Ed．, the Encyclopedia of Endocrine Diseases Academic Press/Elsevier, San Diego． 2004; 164-169．

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