中科院昆明动物研究所导师介绍:李文辉
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李文辉,男,博士,副研究员,硕士生导师。 主要从事两栖爬行动物毒素蛋白多肽分子生物多样性,结构与功能研
李文辉,男,博士,副研究员,硕士生导师。
主要从事两栖爬行动物毒素蛋白多肽分子生物多样性,结构与功能研究。通过对两栖爬行动物毒素蛋白多肽家族的结构变异与功能分化的系统研究,为临床创新治疗药物的开发提供先导结构,同时有助于揭示人类自身生理、病理的分子机制。目前的主要研究为:1)蛇毒凝集素样蛋白及其对血小板膜糖蛋白受体作用及信号转导机制;2)两栖类皮肤蛋白多肽组 (主要针对抗菌肽)。目前负责二项国家自然科学基金及中国科学院“西部之光”重点项目一项。
获奖情况:
[1] 1997 年度云南省科技进步奖,一等奖(第五完成人)。
[2] 2002 年度云南省科学技术奖(自然科学类),一等奖(第二完成人)。
近期发表的主要论文:
* [1] Lee Wen-Hui,Zhuang Qi-Ying,and Zhang Yun,2003.Cloning and characterization of a blood coagulation factor IX-binding protein from the venom of Trimeresurus stejnegeri.Toxicon,41,765-772.
* [2] Lee Wen-Hui and Zhang Yun,2003.Molecular cloning and characterization of a platelet glycoprotein Ib-binding protein from the venom of Trimeresurus stejnegeri.Toxicon,41,885-892.
* [3] Lee Wen-Hui,Du Xiao-Yan,Lu Qiu-Min,Kenneth J.Clemetson,and Zhang Yun,2003.Stejnulxin,a novel snake C-type lectin-like protein from Trimeresurus stejnegeri venom is a potent platelet agonist acting specifically via GPVI.Thrombosis and Haemostasis,90,662-671.
[4] Zhang Yu-Jie,Wang Jian-Hua,Lee Wen-Hui,Wang Qian,Liu Hen,Zheng Yong-Tang,and Zhang Yun,2003.Molecular characterization of Trimeresurus stejnegeri venom L-amino acid oxidase with potential anti-HIV activity.Biochem Biophys Res Commun.,309,598-604.
[5] He Ying-Ying,Lee Wen-Hui,Zhang Yun,2004.Molecular cloning and characterization of a -neurotoxins from Ophiophagus hannah venom.Toxicon,44,295-303.
[6] Wang Ting,Zhang Jie,Shen Ji-Hong,Jin Yang,Lee Wen-Hui,and Zhang Yun,2005.Maximins S,a novel group of antimicrobial peptides from toad Bombina maxima.Biochem Biophys Res Commun.,327,945-951.
* [7] Lee Wen-Hui,Liu Shu-Bai,Shen Ji-Hong,Jin Yang,and Zhang Yun,2005.Cloning of bradykinin precursor cDNAs from skin of Bombina maxima reveals novel bombinakinin M antagonists and a bradykinin potential peptide.Regulatory Peptides,127,207-215.
* [8] Lee Wen-Hui,Liu Shu-Bai,Shen Ji-Hong,Jin Yang,Lai Ren and Zhang Yun,2005.Identification and molecular cloning of a novel neuromedin U analog from the skin secretions of toad Bombina maxima.Regulatory Peptides.129,43-7.
* [9] Lee Wen-Hui,Li Yan,Lai Ren,Li Sha,Zhang Yun and Wang Wen,2005.Variety of Antimicrobial Peptides in the Bombina maxima Toad and Evidence of their Rapid Diversification.Eur.J.Immunol.,35,1220-1229.
[10] Zhang J,Zhang Y,Wan SG,Wei SS,Lee WH and Zhang Y,2005.Bm-TFF2,a trefoil factor protein with platelet activation activity from frog Bombina maxima skin secretions.Biochem.Biophys.Res.Commun.,330,1027-1033.
* [11] Jin Y,Lee WH ( 共同第一作者 ),Zhang Y,2007.Molecular cloning of serine proteases from elapid snake venoms.Toxicon 49,1200-7.
* [12] Jin Y,Lee WH ( 共同第一作者 ),Zeng L,Zhang Y,2007.Molecular characterization of L-amino acid oxidase from king cobra venom.Toxicon.[ already published on line,see:http://www.sciencedirect.com ]
[13] Guo XX,Zeng L,Lee WH,Zhang Y,Jin Y,2007.Isolation and cloning of a metalloproteinase from king cobra snake venom.Toxicon 49,954-65.
[14] Du XY,Sim DS,Lee WH,Zhang Y,2006.Blood cells as targets of snake toxins.Blood Cells Mol Dis.36,414-21.
[15] Wan SG,Jin Y,Lee WH,Zhang Y,2006.A snake venom metalloproteinase that inhibited cell proliferation and induced morphological changes of ECV304 cells.Toxicon 47,480-9.
[17] Wan SG,Jin Y,Lee WH,Zhang Y,2006.Cloning of two novel P-III class metalloproteinases from Trimeresurus stejnegeri venom gland.Toxicon 47,465-72.
[18] Zhang YX,Lai R,Lee WH,Zhang Y,2005.Frog albumin is expressed in skin and characterized as a novel potent trypsin inhibitor.Protein Sci.14,2469-77.
* [19] Lee WH,Zhang J,Zhang YX,Jin Y,Lai R,Zhang Y,2005.Maximin 9,a novel free thiol containing antimicrobial peptide with antimycoplasma activity from frog Bombina maxima.FEBS Lett.579,4443-8.
中国科学引文数据库收录论文
* [1] 李文辉,张云,2003。蛇毒 C -型凝集素研究进展。动物学研究,24,151 - 160.
* [2] 李文辉,高荣,张云,2003。竹叶青蛇毒丝氨酸蛋白酶的分子克隆和序列比较。动物学研究,24,180 - 185.
[3] 韦双双,张英霞,李文辉,张云,2005。眼镜王蛇泛素( Ubiquitin )融合蛋白基因和核糖体蛋白 L30 基因的克隆及分析。动物学研究,26,397-403
* [4] 张杰,韦双双,张勇,张英霞,李文辉 (通讯作者),2005。大蹼铃蟾皮肤膜联蛋白Ⅱ相关蛋白的分离纯化及活性。动物学研究,26,404-409
[5] 张英霞,李文辉,张云,2005。非洲爪蟾血清白蛋白的分离纯化及胰蛋白酶抑制活性。动物学研究,26,622-626
联系信息:
Email:leewh@mail.kiz.ac.cn
地址:昆明市教场东路32号中国科学院昆明动物研究所
邮编:650223
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