中科院昆明动物研究所导师介绍:宿兵
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宿兵,中国科学院知识创新工程比较基因组学学科带头人; 中科院“百人计划”引进人才,理学博士,研究员,博士生导师;中科院昆明动物研究所细胞与分子进化重点实验室主任;美国辛辛那提大学助理教授;复旦大学生命科学院客座
宿兵,中国科学院知识创新工程比较基因组学学科带头人; 中科院“百人计划”引进人才,理学博士,研究员,博士生导师;中科院昆明动物研究所细胞与分子进化重点实验室主任;美国辛辛那提大学助理教授;复旦大学生命科学院客座教授;从事灵长类比较基因组学及现代人类起源和迁徙的研究。已在《Science》、《Nature Reviews Genetics》、《PNAS》、《American Journal of Human Genetics》、《Human Molecular Genetics》和《Molecular Biology and Evolution》等国际核心刊物上发表论文40余篇。曾获中国科学院自然科学奖一等奖(1996);云南省自然科学一等奖(2002) 和教育部科技进步一等奖(2003)。
研究方向:
人类的起源是生命进化的奇迹,也是长期以来生命科学领域受到广泛关注的重大课题之一。人类区别于非人灵长类最为显著的特征是人类发达的大脑。大脑容量急剧增加和认知能力的巨大飞跃是人类起源的关键所在。然而,导致人类这一根本性变化的遗传学机制尚不清楚。
我们采用DNA芯片、DNA序列分析、基因组文库构建和转基因动物等方法,比较人类和非人灵长类大脑认知功能区(如前额叶区)基因表达的差异;探讨在灵长类大脑发育中起关键作用基因和基因家族的分子演化模式和规律。
另一方面,我们还开展对人类起源和史前迁徙的分子考古学研究。采用古DNA分析的方法对人类化石和遗骸进行研究,探索东亚现代人起源的方式,重建其史前迁徙的路线,了解人类群体遗传结构的历史变迁及其与人群文化、语言分化以及人类遗传疾病的关系。
近期研究课题:
1.人类和非人灵长类大脑前额叶学习、记忆功能区基因表达谱的研究。
2. 人类和非人灵长类大脑快速进化基因的研究。
3. 东亚现代人起源和史前迁徙的研究。
4.灵长类基因组文库的构建与灵长类基因组的演化研究。
5.人类中枢神经系统疾病的遗传学基础研究。
团队成员:
目前,实验室共有研究人员14人,其中博士生6人,硕士生6人,技术员1人。
近期发表论文:
Wang YQ, Su B. 2004 Molecular evolution of microcephalin, a gene determining human brain size. Human Molecular Genetics (in press)
Qian, YP, Jin L, Su B. 2004 Construction and characterization of bacterial artificial chromosome library of black-handed spider monkey (Ateles geoffroyi) Genome 47:239-245.
Xu HL., Qian YP., Nie WH., Chi JX., Yang FT., Su B. 2004 Construction, characterization and chromosomal mapping of bacterial artificial chromosome (BAC) library of Yunnan snub-nosed monkey (Rhinopithecus bieti)。 Chromosome Research 12:251-262.
Lell, JT., Sukernik, RI., Starikovskaya, YB., Su B. et al. 2002 The dual origin and Siberian affinities of Native American Y chromosomes. American Journal of Human Genetics 70:192-206.
Wells RS, Yuldasheva NY, Ruzibakiev RM, Underhill PA, Evseeva I, Blue-Smith J, Jin L, Su, B. et al. 2001 The Eurasian heartland:A continental perspective on Y-chromosome diversity. PNAS 98:10244-10249.
Ke YH, Su B.(co-first author) et al. 2001 No independent origin of modern humans in East Asia: a tale of 12,000 Y chromosomes. Science 292:1151-1153.
Ramana GV, Su B et al. 2001 Y chromosome SNP haplotypes suggest evidence of gene flow among caste, tribe, and the migrant Siddi populations of Andhra Pradesh, South India. Eur. J. Hum Genet. 9:695-700
Su, B et al. 2001 Genetic diversity and population history in Red Panda (Ailurus fulgens) as inferred from mitochondrial DNA sequence variations. Molecular Biology and Evolution 18:1070-1076.
Akey, J.M.;Sosnoski, D.;Parra, E.;Dios, S.;Hiester, K.;Su, B. et al. 2001
Melting Curve Analysis of SNPs (McSNP): A Gel-Free and Inexpensive Approach for SNP Genotyping. BioTechniques 30:358-367
Ke, YH., Su, B et al. 2001 Y-chromosome haplotype distribution in Han Chinese populatiions and modern human origin in East Asians. Science in China (Series C) 44:225-232.
Ke, YH., Su, B et al. 2001 Y-chromosome evidence for no independent origin of modern human in China. Chinese Science Bulletin 46:935-937.
Su, B et al. 2000 Y chromosome haplotypes reveal prehistorical migrations to the Himalayas. Human Genetics 107:582-590
Su, B et al. 2000 Distributions of three HIV-1 resistant polymorphisms (SDF1-3''A, CCR2-64I, and CCR5-?32) in Global Populations. European Journal of Human Genetics 8:939-945
Su, B et al. 2000 Polynesian Origins: New Insights from the Y-chromosome PNAS, USA 97:8225-8228
Jin L and Su B. 2000 Natives or Immgrants: Modern human origin in East Asia. Nature Reviews Genetics 1:126-133.
Qian YP, Qian BZ, Su B. 2000 Multiple Origins of Tibetan: Y Chromosome Evidences. Human Genetics 106:453-454
Peterson, B., Su, B et al., 2000 World population data for the HLA-DQA1,PM and D1S80 loci with least and most common profile frequencies for combinations of loci estimated following NRC II guidelines. Journal of Forensic Science. 45 (1):118-146
Su, B et al. 1999 Y Chromosome evidence for a Northward Migration of Modern Humans into East Asia during the Last Ice Age. American Journal of Human Genetics 65:1718-1724
Su, B et al. 1999 Distribution of two HIV-1 polymorphisms (SDF1-3‘A and CCR2-64I) in East Asia and world populations and its implication in AIDS epidemiology. American Journal of Human Genetics 65:1047-1053
Su, B et al. 1999 Phylogenetic study of complete cytochrome b genes of musk deer (genus Moschus) using museum samples. Molecular Phylogentics and Evolution 12:241-249
Chakraborty, R., Stivers, DN. and Su, B et al., 1999 The utility of short tandem repeat loci beyond human identification: Implications for development of new DNA typing systems. Electrophresis 20:1682-1696
Su, B et al. 1998 Frequency of an HIV-resistant allele is exceptionally high in New Guinea Highlanders. Journal of the American Medical Association, JAMA. 280:1830
联系信息:
电话:0871-5120202 (实验室);0871-5120212(办公室)
Email:sub@mail.kiz.ac.cn 或 bing.su@uc.edu
地址:昆明市教场东路32号中国科学院昆明动物研究所
邮编:650223
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